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Otitis Externa/Swimmer's Ear
Published in Charles Theisler, Adjuvant Medical Care, 2023
Acetic Acid: Acidification of the ear canal with a topical solution of 2% acetic acid (VoSol) combined with hydrocortisone (VoSol HC Otic) for inflammation is an effective treatment in most cases.3 Acetic acid is known for its antimicrobial effect on bacteria. Acetic acid is present in vinegar in a 3%-5% concentration. Vinegar has been used in medicine for thousands of years.1, 4 To promote continuous contact, a soft cotton gauze plug (ear wick) can be inserted into the ear canal. The wick is then saturated with the acetic acid solution. Patients should keep the wick in for the first 24 hours and keep it moist by adding 3-5 drops of the solution every 4-6 hours. After 24 hours the wick can be removed, but the patient should continue to instill five drops of (2%) acetic acid otic solution three or four times daily thereafter for five to seven days or as long as needed. In pediatric patients, 3-4 drops may be sufficient due to the smaller capacity of the ear canal.1, 5
Potential of Spices As Medicines and Immunity Boosters
Published in Amit Baran Sharangi, K. V. Peter, Medicinal Plants, 2023
Minoo Divakaran, K. Nirmal Babu, K. V. Peter
The seeds of Nigella have melanthin, a chemical similar to helleborin and, have diuretic, anthelmintic, and emmenagogue properties, like saponin, therefore used as a corrective of laxatives. Possessing actions as a galactagogue, they are given to lactating mothers, along with other medicines. Seeds mixed with powdered camphor, are used to protect wardrobes from insect damage all over India. The seeds possess antibilious property administered internally to arrest vomiting. Relief from cold and inflammation of mucous membranes in the airways of the nose are obtained by inhaling fried seeds tied in a muslin bag. A concoction with Nigella seeds, cumin seeds, black pepper, raisins, tamarind pulp, pomegranate juice and sonchal salt with molasses syrup and honey is used to overcome loss of appetite and distaste for food. Application of seed powder in vinegar for skin infestations and baldness has been indicated by Weiss (2002). However, usage of Nigella seeds is to be done with caution, as its volatile oil yields melanthin, nigelline, damascene, and tannin, of which melanthin is toxic, when consumed in large dosages and nigelline is paralytic. The traditional use of Nigella seeds in curing dyslipidemia, hyperglycemia, and related abnormities, indicated a relative toxicity of this plant (Malhotra 2006). Nigella is also used in preservation as its alcoholic extract shows antibacterial activity.
Healthy Cooking Techniques
Published in Nicole M. Farmer, Andres Victor Ardisson Korat, Cooking for Health and Disease Prevention, 2022
Joel J. Schaefer, Mary Schaefer
Vinegar: Balsamic, white balsamic, apple cider, red wine, white wine, and champagne vinegars are the ultimate flavor enhancers. They are the perfect condiment to salads and perfect to splash over poultry, seafood, and vegetables.
Fiber mixture-specific effect on distal colonic fermentation and metabolic health in lean but not in prediabetic men
Published in Gut Microbes, 2022
Emanuel E. Canfora, Gerben D.A. Hermes, Mattea Müller, Jacco Bastings, Elaine E. Vaughan, Marco A. van Den Berg, Jens J. Holst, Koen Venema, Erwin G. Zoetendal, Ellen E. Blaak
Another important aspect to be considered when studying the effect of gut microbial-derived SCFA on host metabolism is the metabolic phenotype of the study participants. A large body of rodent data suggests a causal link between gut microbiota alterations and metabolic disorders.20 In humans, the microbiota of people with obesity and insulin resistance seems to be characterized by a lower microbial diversity as compared to the healthy, lean microbiota.20,21 Furthermore, the effect of exogenous- and microbially derived SCFA on the substrate and energy metabolism may differ between metabolic phenotypes. Intervention studies with vinegar (with principal compound acetate) and acetogenic indigestible carbohydrates seem to be more effective in improving glucose homeostasis and insulin sensitivity in metabolically ‘healthy’ individuals compared with individuals with impaired glucose homeostasis, insulin resistance, or T2DM.22–24 Interestingly, when acetate was infused intravenously (2.5 mmol/min for 60 minutes) the acetate clearance rate was lower and the half-life time was longer in patients with T2DM than in non-diabetic individuals, indicating a disturbed uptake and/or catabolism of acetate, which might be relevant to elicit acetate-induced metabolic effects in peripheral tissues.22 In support, acute intravenously administered acetate led to a greater free fatty acid fall and rebound in healthy compared with hyperinsulinaemic individuals, and this rebound in free fatty acids was negatively correlated with insulin sensitivity indices.25
Estimation of the risk of local and systemic effects in infants after ingestion of low-concentrated weak acids from descaling products
Published in Clinical Toxicology, 2022
Arjen Koppen, Claudine C. Hunault, Regina G. D. M. van Kleef, Agnes G. van Velzen, Remco H. S. Westerink, Irma de Vries, Dylan W. de Lange
Accidental exposure of infants to electric kettle descalers, for instance due to the preparation of baby milk with water still containing descaler, is often reported to the Dutch Poisons Information Center (DPIC). Household kettle descalers usually contain weak acids, including both organic and inorganic acids, like acetic acid, citric acid, phosphoric acid or sulfamic acid. The DPIC is consulted >100 times per year about exposures of infants to descalers used to descale kettles and coffee machines. In most of these cases reported to the DPIC vinegar was used as descaler, although descalers containing stronger acids were also involved (Supplementary data). In ∼70% of the vinegar exposures cleaning vinegar was involved, the other cases involved cooking vinegar. Both types of vinegar contain at least 4% vinegar, but cleaning vinegar is usually more concentrated with possible concentrations up to 10%. The UK National Poisons Information Service (NPIS) received 230 inquires relating to kettle descaler exposures of children (<2 years) in 2009–2013, the Czech Toxicological Information Center received 14 inquires in 2009 about descalers diluted in milk drinks (children <3 years) [1,2], indicating that the exposure of infants to kettle descalers is, at least in Europe, a widespread phenomenon. The important question is whether such exposures can result in adverse health effects.
Vinegar-processed Curcuma phaeocaulis promotes anti-angiogenic activity and reduces toxicity in zebrafish and rat models
Published in Pharmaceutical Biology, 2021
Wan Liao, Yi Chen, Zongping Zhu, Jiao Chen, Tianhui Gao, Boonjai Limsila, Yenchit Techadamrongsin, Lei Wang, Jiali Yu, Chaomei Fu, Rui Li
In the experiment of changes in toxicity of raw C. phaeocaulis and its vinegar-processed products in female rats at sexual maturity, we established a blood stasis syndrome model based on earlier investigations. Noteworthily, we found that, compared to the control, the rats in each group showed lower weight gain, except for the model + vinegar -processed group, which showed no significant difference in body weight. Compared to the control, the wet weight and ovarian coefficients of model control and model treatment groups that contained C. phaeocaulis were significantly higher, whereas there was no significant difference in the vinegar -processed C. phaeocaulis group and other C. phaeocaulis groups. These experimental results indicate that the effect of C. phaeocaulis on control rats group was significantly higher than on the model rats, and the curative effect of raw C. phaeocaulis was better than the processed product. However, to establish guidelines for clinically safe medication, further studies are warranted. The effects of C. phaeocaulis in normal mature female rats and blood stasis syndrome were investigated, and the safety of clinical drugs was guided by the idea of ‘no death.’ The toxicity of zedoariae was also investigated. In conclusion, the present studies demonstrated that processing with vinegar could alleviate toxicity, and enhance anti-angiogenic activity. This study provides preliminary evidence for the effect of vinegar-processed C. phaeocaulis and CHMs processing.