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Consumer Views on Health Issues Arising from Food Products
Published in Megh R. Goyal, Preeti Birwal, Santosh K. Mishra, Phytochemicals and Medicinal Plants in Food Design, 2022
Harita R. Desai, Murlidhar Meghwal
Toxicological studies on human and animal volunteers for short-term and long-term exposure can aid to arrive at Dose-Response Data, which can help to extrapolate the minimum and maximum tolerable exposures. Processing of Pharmacodynamic data from these studies also aid to arrive at the mechanism of action by which such chemical exposures can affect our body [30]. Preparation and reference of detailed “Material Safety Data Sheets” can help in easy identification of health hazards. Some common chemical hazards identified with food are indicated in Table 6.1.
Sample Protocols for Carcinogenesis and Photocarcinogenesis
Published in Francis N. Marzulli, Howard I. Maibach, Dermatotoxicology Methods: The Laboratory Worker’s Vade Mecum, 2019
P. Donald Forbes, Christopher P. Sambuco, George E. Dearlove, Robert M. Parker, Anthony L. Kiorpes, John H. Wedig
General safety precautions as required by Testing Facility Laboratories’ policies and procedures will be followed. The Sponsor’s representative will be notified of any personnel exposures requiring a physician’s examination or care. A material safety data sheet (MSDS) is on file at Testing Facility Laboratories for the test material.
Risk Assessment and Management in the Workplace
Published in David Woolley, Adam Woolley, Practical Toxicology, 2017
For chemicals, COSHH Essentials is based on this process. The Material Safety Data Sheet should contain classification and labeling information. That information leads to a categorization of the chemical and hence to an indication of what are appropriate management procedures. Obviously, certain categories lead to the evaluation “seek expert advice,” which, if available, may lead to alternative approaches to managing the chemical safely.
Quality assurance for nanomaterial inhalation toxicity testing
Published in Inhalation Toxicology, 2021
Sung Kwon Lee, Mi Seong Jo, Hoi Pin Kim, Jong Choon Kim, Il Je Yu
Physicochemical characterization of test nanomaterials should be done in the context of test article characterization as described in the OECD Principles of on GLP (OECD 1997) and OECD TG 412 and 413. Prior to the start of the study, there should be a characterization of the test chemical or nanomaterial, including its purity and, if technically feasible, the identity and quantities of identified contaminants and impurities. When compared with conventional chemical inhalation testing, the new QA considerations for the revised inhalation toxicity testing essentially focus on prior identification of the physicochemical properties of the test nanomaterial, the particle characterization methods, and the selection and monitoring of the aerosol generator. The particular physicochemical properties of nanomaterials related to toxicity testing are already detailed in ISO/TR 13014 (2012) and include the particle size, size distribution, aggregation/agglomeration, surface characteristics, crystalline structure, electrical properties, dustiness, composition, and purity (Supplement 3). This information needs to be obtained from the manufacturer before any aerosol generation for inhalation toxicity testing. The manufacturer is responsible for providing a CoA (Certification of Analysis) for the test nanomaterial that includes its physicochemical properties (as extensive as possible). The manufacturer must also include this same information in the MSDS (Material Safety Data Sheet). For QA, this information should be reviewed before any aerosol generation.
Application of Pythagorean fuzzy AHP and VIKOR methods in occupational health and safety risk assessment: the case of a gun and rifle barrel external surface oxidation and colouring unit
Published in International Journal of Occupational Safety and Ergonomics, 2020
The corrective–preventive actions suggested for H16 involve the flammable and explosive environments measurements. In particular, by identifying flammable and flammable environments, the spark sources in these regions should be protected. Illumination equipment should be held in an explosion-proof environment. Natural gas centres should be marked with signs. The explosion protection document will be reviewed. For H20, employees should urgently be required to obtain a vocational training certificate by interviewing relevant educational institutions. For the third and fourth most serious hazards, H17 and H13, the following measures should be taken into consideration. All chemicals used in the operation should be listed in sections. An update of missing material safety data sheets (MSDS) should be provided. Then, MSDS should be supplied for all chemical intake and should be filed in the infirmary and in places where employees can access them. In particular, the storage of the chemicals should be carried out from one centre. A new and appropriate chemical storage zone should be established. During work, appropriate ear protection supplies and utilization should be ensured by evaluating the results of environmental measurements made to detect noise levels of work equipment. Employees should be trained on usage of personal protective equipment.
β-Phenylethylamine and various monomethylated and para-halogenated analogs. Acute toxicity studies in mice
Published in Drug and Chemical Toxicology, 2020
Aron D. Mosnaim, Marion E. Wolf, James J. III. O’Donnell, Thomas Hudzik
Studied p-mHPEAs and mMPEAs are used as intermediaries in the synthesis of various organic compounds (Kloos et al. 2012, pubchem.ncbi.nlm.nih.gov2018) and classified, but not regulated, by the Occupational Safety and Health Administration (OSHA; osha.gov), an agency of the United States Department of Labor (uol.gov), under at least one cautionary toxicity label e.g., GHS05, GHS06. These compounds can be purchased from multiple sources which are mostly unregulated, shadow companies domiciled mostly in South East Asia; in this case is recommended that before use their purity and further, even their actual identity should be verified (erowid.org/experiences2018). Reputable suppliers are few and include Sigma-Aldrich Co (WI) and Cayman Chemicals Co (MI) (sigmaaldrich.com, caymanchemical.com 2018). They provide a Material Safety Data Sheet (MSDS) with known toxicity information available, mostly from the Registry of Toxic Effects of Chemicals Substances (RTECS) compiled by The National Institute for Occupational Safety and Health (NIOSH), which is part of the Centers for Disease Control and Prevention (CDC) within the U.S. Department of Health and Human Services (hhs.gov) (MSDS, RTECS 2018)