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Controversies in Recurrent Implantation Failure: From Theory to Practice
Published in Botros Rizk, Yakoub Khalaf, Controversies in Assisted Reproduction, 2020
Efstratios Kolibianakis, Pavlidi Olga, Christos A. Venetis
Although assisted reproductive technologies (ARTs) have helped numerous couples to achieve live birth, this is not feasible in a significant proportion of cases, despite several attempts. Repeated implantation failure (RIF) remains a difficult problem both for clinicians, struggling to help patients, as well as for patients, anxiously seeking solutions.
Recurrent implantation failure
Published in David K. Gardner, Ariel Weissman, Colin M. Howles, Zeev Shoham, Textbook of Assisted Reproductive Techniques, 2017
David Reichman, Hey-Joo Kang, Zev Rosenwaks
Human reproduction is inefficient, as evidenced by a mean delivery rate of 37.3% per fresh embryo transfer in the U.S.A. in 2013 (1). Despite advances in assisted reproductive technologies over the past four decades, patients remain who fail to achieve live births following multiple in vitro fertilization (IVF)/embryo transfer cycles. Although delivery rates have improved, in the majority of failed implantation cycles, no identifiable etiology is found. Thus, isolating a specific cause for repeated implantation failure can be challenging. Patient age, genetic constitution of embryos, culture conditions, and endometrial receptivity have all been implicated in recurrent implantation failure (RIF).
Noninvasive amino acid turnover predicts human embryo aneuploidy
Published in Gynecological Endocrinology, 2022
I. Orcun Olcay, Berkay Akcay, Mustafa Bahceci, Aydin Arici, Kubra Boynukalin, Cengiz Yakicier, Aysel Ozpinar, Murat Basar
Aneuploidy screening as embryo selection criteria will ensure that the transferred embryos are euploid [6]. Although some of the chromosomal errors can be assigned to suboptimal culture environments and oocyte aging [26], it is well known that the genetic composition of embryos created by IVF has identified two groups of patients who have a high risk of chromosomally abnormal embryos [4,5]. These involve (i) patients of advanced maternal age [27] and (ii) patients with repeated implantation failure [4,5]. Because an increasing proportion of women undergoing medically assisted reproduction are over 35years old, these observations are become vital [28]. Although this evidence supports the use of aneuploidy screening in defined patient groups, together with the invasive nature of the biopsy procedure and the extra time and expense incurred, it may not justify the widespread application of this technique as a routine method for embryo selection across all patients’ groups. Indeed, the use of aneuploidy screening for this purpose has been questioned [29–34].
Effect of platelet-rich plasma on pregnancy outcomes in infertile women with recurrent implantation failure: a randomized controlled trial
Published in Gynecological Endocrinology, 2021
Marzieh Zamaniyan, Sepideh Peyvandi, Hassan Heidaryan Gorji, Siavash Moradi, Jaefar Jamal, Fatemeh Yahya Poor Aghmashhadi, Mohammad Hossein Mohammadi
Infertility is defined as the lack of pregnancy after at least one year unprotected intercourse, and its prevalence is about 9% among women [1]. Different methods are used for the treatment of infertility, but advanced treatments are used for routine infertility treatment failure. Advanced infertility treatment involves in vitro Fertilization (IVF) which has a success rate of about 30%. Embryo culture and transfer methods have been developed in IVF clinics for more than two decades, but clinical pregnancy rates have not improved significantly [2]. Recurrent implantation failure is one of the frequent problems faced by a doctor and a patient at infertility centers. The repeated implantation failure is defined as non-pregnancy after three in vitro fertilization or after the transfer of 10 good-quality embryos into the uterus [3–5]. The reasons for this failure are uterine causes, such as thin endometrium, poor endometrial receptivity, immune incompatibility, and embryos origins. Different treatment protocols have been used for thin endometrium, but the last recommended treatment has been intrauterine injection of platelets [5–21].
Administration of prednisolone and low molecular weight heparin in patients with repeated implantation failures: a cohort study
Published in Gynecological Endocrinology, 2018
Charalampos Siristatidis, Konstantinos Dafopoulos, Waleed El-Khayat, George Salamalekis, George Anifandis, Tereza Vrantza, Mostafa Elsadek, Nikolaos Papantoniou
The process of implantation remains an impeccable barrier regarding the increase of successful pregnancy outcomes in Assisted Reproduction Technologies (ART). The process requires an embryo with increased implantation potential, a receptive endometrium and a highly coordinated signaling with precise crosstalk between the two sides. Repeated implantation failure (RIF) describes the clinical situation where a woman repeatedly fails to achieve pregnancy after the transfer of good-quality embryos [1,2]. Among the methods proposed to overcome RIF, co-administration of low molecular weight heparin (LMWH) alone or together with glucocorticoids have been suggested. The rationale of the use of both drugs is hidden behind the improvement of both implantation and placentation processes [3].