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Pathophysiological mechanisms of chronic pain
Published in Jennifer Corns, The Routledge Handbook of Philosophy of Pain, 2017
CCS, unlike wind-up and LTP, is not limited to the synapses which initiated the neurochemical response; rather it alters both local and remote receptor complexes, making them more likely to be activated. This has several important effects including the unsilencing of normally “silent” synapses to form functional synapses, functionally apparent as increases in the receptive fields of the postsynaptic neurons.
ENTRIES A–Z
Published in Philip Winn, Dictionary of Biological Psychology, 2003
A SYNAPSE which is present but not participating in signaling. If LONG-TERM POTENTIATION (LTP) is induced, any RECEPTOR which was inactive can be activated. This is thought to involve the recruitment of previously silent synapses.
Climbing the ladder from neuron to brain in Harold Atwood’s laboratory
Published in Journal of Neurogenetics, 2018
In summary, my work with Harold Atwood contributed some valuable experimental and theoretical evidence for the existence and importance of silent synapses in the crayfish neuromuscular junction. In doing so we also added substance towards building a case for considerable physiological parallels between the crustacean junctions and the mammalian central nervous system. Our work culminated in a paper (Wojtowicz, Marin, & Atwood, 1994), which made a solid case for some synapses being nearly silent while others being always active. The concept is clearly applicable to various forms of synaptic plasticity such as LTF and LTP in the mammalian brain (Bliss & Lomo, 1973). The idea of silent synapses being activated during LTP has been adopted by researchers studying the mammalian brain and expanded to include other multiple types of synapses utilizing a variety of glutamate receptors, such as AMPA and NMDA receptors (Hanse, Seth, & Riebe, 2013).