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Brain Health
Published in Carolyn Torkelson, Catherine Marienau, Beyond Menopause, 2023
Carolyn Torkelson, Catherine Marienau
One of few studies currently available on diet and the brain is the MIND diet study, which is a combination of a Mediterranean–DASH diet intervention for neurodegenerative delay (discussed in Chapter 9). The diet emphasizes natural and plant-based foods with limited intakes of animal-based and high saturated fat foods. Those who strictly adhered to the diet had a 53% reduction in risk for Alzheimer’s disease, and those who adhered moderately had a 35% reduction.9
Alzheimer's Disease (AD)
Published in Charles Theisler, Adjuvant Medical Care, 2023
Diets: According to research, moderate adherence to the hybrid MIND diet—which combines elements of the Mediterranean diet and the Dietary Approaches to Stop Hypertension (DASH) diet—may significantly lower the risk (54%) of developing Alzheimer disease.26
Psychosocial Aspects of Diabetes
Published in Jahangir Moini, Matthew Adams, Anthony LoGalbo, Complications of Diabetes Mellitus, 2022
Jahangir Moini, Matthew Adams, Anthony LoGalbo
The prevention for AD may involve diets such as the Mediterranean diet, the similar MIND diet, and other healthy eating patterns such as the DASH diet. The MIND diet combines features of the Mediterranean and DASH diets, focusing specifically on brain health. The letters M-I-N-D stand for Mediterranean-DASH Intervention for Neurodegenerative Delay. It encourages consumption of berries, green leafy vegetables, nonstarchy vegetables, nuts, olive oil, whole grains, fish, beans, poultry, and 1 glass of wine per day. Foods to limit include butter, margarine, cheese, red meat, fried food, pastries, and sweets. The diet has also been shown to slow cognitive decline significantly during an average of 5 years. The effects of good diet improve cardiovascular health, which can reduce dementia risk. Good physical activity, control of blood pressure, and cognitive training also are known to help prevent development of dementia.
The association between adherence to the MIND diet and stroke: a case–control study
Published in Nutritional Neuroscience, 2022
Asma Salari-Moghaddam, Saeedeh Nouri-Majd, Forough Shakeri, Ammar Hassanzadeh Keshteli, Sanaz Benisi-Kohansal, Mohammad Saadatnia, Ahmad Esmaillzadeh
Ischemia is the main pathophysiology known for stroke that occurred by cardiac embolism, occlusion of small vessels, and atherosclerosis of the cerebral circulation [23]. In addition, inflammation and vascular oxidative stress greatly leads to atherosclerosis in different locations [24]. Our findings could be attributed to the individual food items of the MIND diet. The MIND diet is based on a combination of Mediterranean and DASH dietary patterns; both emphasize on natural plant-based foods and restricted intake of animal and high saturated fat foods. Components of the MIND diet are rich in vitamin E, folate, n-3 fatty acids, carotenoids, and flavonoids [10], which can reduce inflammation and oxidative stress in vascular endothelial cells [25]. Therefore, a hypothesis is that the MIND diet can reduce the risk of stroke by decreasing inflammation and oxidative stress in vascular endothelial cells.
Evaluation of dietary and lifestyle changes as modifiers of S100β levels in Alzheimer’s disease
Published in Nutritional Neuroscience, 2019
Nathan M. D’Cunha, Andrew J. McKune, Demosthenes B. Panagiotakos, Ekavi N. Georgousopoulou, Jackson Thomas, Duane D. Mellor, Nenad Naumovski
Dietary modifications have been identified as of interest for prevention of chronic diseases such as AD, although the optimal dietary patterns for individuals with AD have not been clearly defined.16 Specific dietary patterns, particularly the Mediterranean diet (MD), which is characterised by high consumption of omega-3 fatty acids and polyphenol-rich foods, such as olive oil, nuts, vegetables and fruits, has been associated with reduced risk of cognitive decline.17–20 In addition, the MIND diet (MD combined with the Dietary Approaches to Stop Hypertension intervention for Neurodegenerative delay) has been associated with a delay in cognitive decline.21 The mechanisms through which specific dietary patterns impart their beneficial effects remain unclear as the majority of available evidence is qualitative and observational in nature, and nutritional research is impaired by a difficulty in isolating specific nutrients and their therapeutic benefits.22
Changes in Brain Volume Associated With Vegetable Intake in a General Population
Published in Journal of the American College of Nutrition, 2019
Sunghee Lee, Eun Young Kim, Chol Shin
The findings of the present study are consistent with those of previous studies. A recent cross-sectional study demonstrated that participants with a higher dietary quality based on the Dutch dietary guidelines exhibited larger total brain, gray matter, white matter, and hippocampal volumes, suggesting that vegetables, nuts, whole grains, fruits, fish, and dairy food groups had beneficial associations (14). Many previous studies on the association between diets and brain structural volume have focused on the Mediterranean diet (3–7). Specifically, a cross-sectional study among 966 adults with an average age of 72 years reported that Mediterranean diet was associated with a lower prevalence of white matter hyperintensities (3). Another cross-sectional investigation of 674 individuals with an average age of 80 years demonstrated that participants with high adherence to the Mediterranean diet featured low brain volume loss; particularly, among nine food groups composing the Mediterranean diet, high fish and low meat groups indicated significant associations with total gray matter volume (5). Furthermore, a longitudinal relationship among 562 Scottish adults aged 73 to 76 years revealed that participants with low adherence to the Mediterranean diet exhibited higher total brain volume loss over 3 years of MRI follow-up (6). An additional longitudinal MRI study among 215 adults with an average age of 79 years demonstrated that higher adherence to the Mediterranean diet for 4.5 years was associated with slower reduction in total hippocampal volume (27). In contrast, a study of 194 cognitively healthy participants who filled out 1-week food diaries reported no association between consumption of Mediterranean diet and cognitive function (7). In a randomized clinical trial among 334 participants over 4 years, participants who consumed a Mediterranean diet plus olive oil or nuts revealed significant improvements in memory as well as frontal and global cognition (28). Furthermore, a recent study comparing the Mediterranean diet, DASH, and MIND showed that the MIND diet—a hybrid between the other two diets—helped to delay cognitive decline (8).