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Pathophysiology of Complex Regional Pain Syndrome
Published in Gary W. Jay, Practical Guide to Chronic Pain Syndromes, 2016
Myoclonus is frequently seen in severe CRPS patients (16,23,150), 151). Clinically, myoclonic jerks can be seen at rest, are aggravated by movement, and are associated with spasms and dystonia. A recent study utilizing intermuscular and corticomuscular coherence analysis demonstrated increased intermuscular coherence in the 6- to 12-Hz band similar to that seen in physiological tremor. Side-to-side coherence was seen in two patients, which is suggestive of a central oscillatory drive (152).
A potential upper motor neuron measure of bulbar involvement in amyotrophic lateral sclerosis using jaw muscle coherence
Published in Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2021
This study aimed to identify a novel quantitative bulbar measure in ALS using beta-band intermuscular coherence. Functionally related muscles are known to be controlled as a unit, allowing for synchronous modulation of these muscles by the oscillations in their shared neural drive (5). Intermuscular coherence—a measure of temporal correlation between the activities of two muscles in the frequency domain—provides a means of detecting the shared oscillatory inputs to these muscles (6,7). Specifically, beta-band (i.e. 15–35 Hz) coherence, which reflects the oscillations originating in the motor cortical network, has been widely used in limb motor studies to assess the neural transmission between the motor cortex and limb muscles (8,9). Disrupted corticospinal pathways secondary to ALS or primary lateral sclerosis (PLS) have been demonstrated to reduce the beta-band coherence between limb muscles (8,9), which provides the evidence and impetus for the utility of beta-band intermuscular coherence in assessing corticospinal involvement. Exactly how bulbar involvement affects bulbar muscle coherence remains unknown, due to the unclear parallels between the bulbar and spinal motor systems.
Neurophysiological features of primary lateral sclerosis
Published in Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2020
Mamede de Carvalho, Matthew C. Kiernan, Seth L Pullman, Kourosh Rezania, MR Turner, Zachary Simmons
Beta-band (15–30 Hz) coupling between muscles (intermuscular coherence) is a physiological phenomenon derived from a common cortical drive transmitted by the corticospinal tract (22). A group of investigators studying intermuscular coherence in upper limb muscles identified severe reduction in 8 PLS patients (10). Issa et al., comparing ALS patients with a control population, found a significantly reduced intermuscular coherence in the ALS group (23). While this may represent a promising technique, more studies will be needed to determine its role in the investigation of PLS patients.
Intramuscular Coherence of the Lower Flexor Muscles during Robotic Ankle-Assisted Gait
Published in Journal of Motor Behavior, 2022
Kei Nakagawa, Naoto Kadono, Tomohiro Shimoda, Takafumi Mitsuhara, Eiichiro Tanaka, Louis Yuge
A previous study showed that newly adapted gait increased the IMC of the two parts of TA muscles in the initial adaptation stage (Sato & Choi, 2019). In an upper limb motor-practice task, intermuscular coherence between the first dorsal interosseous (FDI) and abductor pollicis brevis (APB) muscles was enhanced following the motor performance improvement (Larsen et al., 2016). Therefore, we hypothesized that the IMC of TA muscle would be enhanced by the RE-Gait intervention if the gait parameters were increased during training.