Cramp fasciculation syndrome

Spinal Cord Disease

Published in Philip B. Gorelick, Fernando D. Testai, Graeme J. Hankey, Joanna M. Wardlaw, Hankey's Clinical Neurology, 2020

Ryan Jacobson, Allison Osen

Cramp-fasciculation syndrome due to peripheral nerve hyperexcitability: Benign fasciculations with normal morphology on EMG.Normal muscle strength without progression to weakness over at least 1 year.

Neurology

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Purchase Book

Published in Shibley Rahman, Avinash Sharma, A Complete MRCP(UK) Parts 1 and 2 Written Examination Revision Guide, 2018

Shibley Rahman, Avinash Sharma

As with other disorders with such a grave prognosis, alternative cause for the patient’s symptoms and signs must be excluded. Several conditions can mimic motor neurone disease, such as benign cramp fasciculation syndrome, cervical radiculomyelopathy, multifocal motor neuropathy with conduction block and inclusion body myositis.

Transient receptor potential ankyrin 1 (TRPA1)-mediated toxicity: friend or foe?

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Journal Information

Published in Toxicology Mechanisms and Methods, 2020

Mohaddeseh Sadat Alavi, Ali Shamsizadeh, Gholamreza Karimi, Ali Roohbakhsh

Cramp-fasciculation syndrome is a rare hypersensitivity-hyperexcitability disorder with fasciculation, muscle cramps, stiffness, paresthesia, fatigue, anxiety, and pain (Tahmoush et al. 1991). Other symptoms include asthma, migraine, gastroesophageal reflux, tremor, and cold hyperalgesia (Tahmoush et al. 1991). A specific variant of TRPA1 has been associated with cramp-fasciculation syndrome by whole-exome sequencing and cosegregation analyses (Nirenberg et al. 2017). Patients are improved following carbamazepine therapy.

Cramp fasciculation syndrome

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Spinal Cord Disease

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Transient receptor potential ankyrin 1 (TRPA1)-mediated toxicity: friend or foe?