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Alien Hand Syndrome
Published in Alexander R. Toftness, Incredible Consequences of Brain Injury, 2023
The name of this disorder, alien hand syndrome, works well in describing its symptoms. The disorder has also been called Strangelovian hand (or Dr. Strangelove syndrome) after the titular character who had some of the symptoms in the movie Dr. Strangelove (Kubrick, 1964). However, the name alien hand syndrome captures the imagination and is the more popular way of referring to the disorder, as it is a memorable name for a memorable diagnosis.
Alien hand syndrome – a rare presentation of stroke
Published in Journal of Community Hospital Internal Medicine Perspectives, 2020
Kelly Le, Christine Zhang, Lisa Greisman
Alien hand syndrome was first described in 1908 by Dr. Hugo Liepmann when he noticed a patient exhibiting an involuntary grasping reflex of the left hand after experiencing a stroke. However, AHS is not a result of a movement disorder. The condition went through several name changes over the years, initially characterized as ‘alien’ by Dr. Kurt Goldstein in 1908. In 1972, Drs. Brion and Jedynak first coined the term ‘alien hand’ after evaluating three patients with callosal tumors who were unable to recognize their own hands.[1] AHS is most often caused by stroke, neurodegenerative illness, midline tumor, aneurysm, or damage to the corpus callosum. AHS can affect the frontal, callosal, and posterior regions. In the frontal variant, patients develop disinhibited groping or grasping. Patients are often aware that the limb belongs to them but have difficulty controlling and suppressing such movements. Patients with the callosal variant develop agnostic dyspraxia, in which one hand does not respond to command, and the opposite hand performs the task. [2] The posterior variant causes impaired motor control and non-recognition of the patient’s own limb. [2]
Treatment-related transient splenial lesion of the Corpus Callosum in patients with neuropsychiatric disorders: a literature overview with a case report
Published in Expert Opinion on Drug Safety, 2020
Giovanna Cirnigliaro, Ilaria Di Bernardo, Valentina Caricasole, Eleonora Piccoli, Barbara Scaramelli, Simone Pomati, Chiara Villa, Leonardo Pantoni, Bernardo Dell’Osso
From a clinical point of view, the SCC lesion can be accompanied by neurological symptomatology. Most cases present with epileptic seizures [26]. Cases of alien hand syndrome following corpus callosum infarction [27], along with a transient-localized lesion of SCC in a child [28], have been described. A case report documented the concomitant onset of a neuroleptic malignant syndrome [16]. An in-depth analysis of these cases is needed to understand the role CLOCCs play across various clinical manifestations reported. In the field, data is likely due to the benign nature of transient SCC lesions and the common complete reversion of neurological symptoms, when present. In addition, asymptomatic SCC lesions may not be recognized in clinical practice unless MRI is performed for other reasons. Therefore, it currently does not seem possible to clarify the exact correlation between SCC lesions and neurological symptoms. Finally, although the overall symptoms of most patients with CLOCCs tend to subside with a good outcome, patients with any clinic-radiological features tend to need longer hospitalization for diagnostic investigations with or without neurological sequelae [29].