China
Africa
Explore chapters and articles related to this topic
Miscellaneous Drugs during Pregnancy
Published in “Bert” Bertis Britt Little, Drugs and Pregnancy, 2022
The most frequent adverse effects of hypermagnesemia include cutaneous flushing, nausea, vomiting, respiratory depression, intracardiac conduction delays. MgSO levels 12 mEq/L or greater are associated with respiratory arrest. Protracted therapy with MgSO for preterm labor increases calcium loss and may decrease bone mineralization (Smith et al., 1992). Prolonged but not clinically significant bleeding time during pregnancy may be associated with magnesium sulfate therapy (Fuentes et al., 1995). Magnesium sulfate is not associated with a “peripheral vascular steal” syndrome, and apparently does not decrease placental perfusion (Dowell and Forsberg, 1995). Use of this drug with indomethacin before 32 weeks for short periods are suggested in some cases (ACOG, 2016).
PerformLyte—A Prodosomed PL425 PEC Phytoceutical-Enriched Electrolyte Supplement—Supports Nutrient Repletion, Healthy Blood pH, Neuromuscular Synergy, Cellular and Metabolic Homeostasis
Published in Abhai Kumar, Debasis Bagchi, Antioxidants and Functional Foods for Neurodegenerative Disorders, 2021
Bernard W. Downs, Manashi Bagchi, Bruce S. Morrison, Jeffrey Galvin, Steve Kushner, Debasis Bagchi
Extraordinarily, inadequate magnesium intake stimulates increased absorption from the intestine, and a large increase in magnesium intake decreases absorption.141–151 Under various physiological conditions, magnesium content in the bloodstream can be either extremely high, termed as “hypermagnesemia,” or exceptionally low, known as “hypomagnesemia.”147,148 It is important to note that absorption, distribution, metabolism, and excretion of magnesium are intricately associated with other electrolytes.147–150 High magnesium level leads to diverse diseases, including diabetic ketoacidosis, adrenal insufficiency, and hyperparathyroidism. Also, excretion of magnesium is restrained especially in patients with kidney dysfunctions.149 Excessive intake of dietary magnesium or magnesium-based drugs cause an increased magnesium level in these patients.147–149
Magnesium homeostasis
Published in Kupetsky A. Erine, Magnesium, 2019
Ravi Sunderkrishnan, Maria P. Martinez Cantarin
Hypermagnesemia occurs due to reduced magnesium excretion or increase magnesium intake. Renal failure (acute and chronic) is the most common cause of hypermagnesemia due to reduced magnesium filtration and excretion. Hypermagnesemia is seen in the oliguric phase of acute renal failure, but once the renal failure starts to resolve, especially in the polyuric phase of acute tubular necrosis (ATN), the magnesium level starts to fall toward normal.
Hypomagnesemia and hypermagnesemia
Published in Acta Clinica Belgica, 2019
Hypermagnesemia is defined by a serum magnesium concentration >1.2 mM (2.5 mg/dL) and is a rare electrolyte disturbance in patients with normal kidney function. With decreasing kidney function, the ability to gradually decrease renal magnesium absorption is offset by a decline in glomerular filtration. Across all stages of CKD, hypomagnesemia is present in about 15% of all patients [14]. According to recent registry data the majority of ESKD patients have normomagnesemia, while a substantial proportion even has hypomagnesemia [26]. This can be explained by dietary factors, including imposed restrictions (also to control potassium) and malnutrition, next to low dialysate concentration, proteinuria, vitamin D deficiency and drugs such as diuretics [14,44]. Also, hypoalbuminemia can contribute to a negative magnesium balance in hemodialysis patients as it will lead to a higher concentration of free and dialyzable ionized fraction.
Safety of epidural drugs: a narrative review
Published in Expert Opinion on Drug Safety, 2019
ML van Zuylen, W ten Hoope, EME Bos, J Hermanides, MF Stevens, MW Hollmann
Magnesium is a NMDA-receptor antagonist, similar to ketamine. The main reason for adding magnesium to an epidural drug-mixture is to reduce side effects of epidural LA and/or opioids, whilst assuring the same level of analgesia [112]. A high dose of magnesium intravenously (resulting in plasma levels >5 mmol/L) can produce flushing and hypotension that is not seen when applied via the epidural route, presumably due to a dose-dependent effect. Very high doses of magnesium resulting in plasma levels exceeding 6mmol/L could lead to hypermagnesemia, a potentially lethal condition.
Impact of admission serum magnesium levels on long-term mortality in hospitalized patients
Published in Hospital Practice, 2020
Wisit Cheungpasitporn, Charat Thongprayoon, Tarun Bathini, Panupong Hansrivijit, Pradeep Vaitla, Juan Medaura, Saraschandra Vallabhajosyula, Api Chewcharat, Michael A Mao, Stephen B. Erickson
In this current study, we demonstrated that admission hypermagnesemia, but not hypomagnesemia, is associated with increased 1-year mortality. This risk increased in parallel with the degree of hypermagnesemia, with the most pronounced risk in patients with serum magnesium level above 2.3 mg/dL. Our cohort is the first study to describe the correlation between admission serum magnesium and 1-year mortality.