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Epidermolysis Bullosa
Published in Charles Theisler, Adjuvant Medical Care, 2023
Nutritional Deficiencies: Involvement of the oral mucosa and esophageal stenosis may be responsible for severe nutritional deficiencies. Most patients have significant growth retardation. Iron, vitamin D, C, B3, B6, zinc, and selenium deficiencies exist in 36%-70% of EB patients.2
Immunosuppressants, rheumatic and gastrointestinal topics
Published in Evelyne Jacqz-Aigrain, Imti Choonara, Paediatric Clinical Pharmacology, 2021
Evelyne Jacqz-Aigrain, Imti Choonara
Adverse drug reactions. Chronic treatment has been associated with multiple side effects, including Cushing’s syndrome during therapy and adrenal insufficiency after discontinuation of treatment. In children, the major side effect is growth retardation. This effect is reduced by alternate day administration.
Long-Term Glucose Infusions in the Treatment of Fetal Growth Retardation
Published in Asim Kurjak, John M. Beazley, Fetal Growth Retardation: Diagnosis and Treatment, 2020
The tests were performed repeatedly, and if the diagnosis of a growth retardation was confirmed, treatment was started. Every day 2 1 of a 10% glucose solution were infused intravenously at a speed of 5 ml/min, i.e. 0.5 g glucose per min. This way the infusions lasted for 6 h and 40 min. As a rule, the infusions were performed for 6 d each week. The last day was reserved for repetition of all tests. If the improvement in the course of therapy was very satisfactory, 1 or 2 d in a week were left free without infusions. The total number of infusions varied between 5 and 35, 14.5 on the average. Usually the infusions were performed up to the delivery.
Undernutrition and malaria among under-five children: findings from the 2018 Nigeria demographic and health survey
Published in Pathogens and Global Health, 2021
Daena M. Mann, Monica H. Swahn, Sarah McCool
In this study, the likelihood of malaria infection was 89% higher among under-five stunted Nigerian children than under-five children who were not stunted. Evidence suggests that there is usually a greater risk of illnesses among children who experience growth retardation due to poor diets and recurrent infections [7]. Similar results were noted in a study conducted among children in Mount Cameroon, where stunted children succumbed to more malaria parasitemia compared to children who were not stunted [17]. Chronic malnutrition, also known as stunting, diminishes immune function and increases the risk and severity of infections. Undernourished children are an attractive host for parasites, while well-nourished children are better able to mount and regulate an immune response and are more adept at resisting and clearing infections [43].
The effects of atomoxetine on weight, height, and body mass index in Turkish children and adolescents with attention deficit hyperactivity disorder
Published in Psychiatry and Clinical Psychopharmacology, 2019
Serkan Turan, Aynur Pekcanlar Akay
When considering the results of the current study, some limitations need to be taken into account. First, our study was a retrospective chart review. Participants with no clinically diagnosed possible conditions associated with growth retardation were selected for the study sample, but there may have been differences between health conditions of the participants, which may affect the anthropometric values. Secondly, we did not consider past treatment regimes which are very important to assess if patients were taking stimulants before atomoxetine. An alternative possible limitation is that we do not evaluate the parental anthropometric values, socioeconomic status, ethnicity, and genetic factors of the ADHD group, which have an effect on our findings. Moreover, we did not consider if comorbid features, such as mood disorders, other neurodevelopmental disorders, or eating disorders, can be associated with z scores’ variations. Another issue of concern is defining other psychopharmacological medications which also influence growth parameters; the impact of this bias is unknown. Another limitation is the availability of chart records which include changes in growth parameters in monthly or three-month intervals with longitudinal growth curves.
Clinical and genetic analysis of distal renal tubular acidosis in three Chinese children
Published in Renal Failure, 2018
Jiaojiao Liu, Qian Shen, Guomin Li, Yihui Zhai, Xiaoyan Fang, Hong Xu
We studied three patients (one girl and two boys) from independent nonconsanguineous families who presented with the clinical features of dRTA. The clinical features are presented in Table 2. Primary dRTA was clinically diagnosed based on the clinical features (i.e., growth retardation, dehydration, and vomiting) and laboratory findings (i.e., non-gap severe metabolic acidosis, high urinary pH, hypokalemia, and nephrocalcinosis) after excluding the secondary causes of dRTA. Two patients were diagnosed at 3 months of age, and 1 patient was diagnosed at 3 years of age. The initial manifestations were either acute, with dehydration and vomiting, or failure to thrive and/or weakness. The physical examination revealed growth retardation, and both the patients’ weight and height were below the 3rd–25th percentile. Rickets was noted in Patient-3. An audiometric evaluation revealed normal hearing at diagnosis in all patients.