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Dish (Forestier Disease) Fractures
Published in Kelechi Eseonu, Nicolas Beresford-Cleary, Spine Surgery Vivas for the FRCS (Tr & Orth), 2022
Kelechi Eseonu, Nicolas Beresford-Cleary
The underlying diagnosis is diffuse idiopathic skeletal hyperostosis (DISH). There are non-marginal syndesmophytes from C2 to T1. The disc spaces remain preserved and non-ossified, which differentiates this condition from ankylosing spondylitis (AS) (Table 11.1).
Pharmacology of Therapeutic Agents in Photomedicine
Published in Henry W. Lim, Nicholas A. Soter, Clinical Photomedicine, 2018
Ira C. Davis, Matthew J. Stiller, Jerome L. Shupack
Chronic effects may involve the skeletal system and the liver. Premature closure of the epiphyses, thinning of the long bones, fractures, and osteoporosis are among the reported side effects in children (60). Adults have developed a disorder resembling diffuse idiopathic skeletal hyperostosis; spinal hyperostoses, extraspinal ligament and tendon calcification, and spinal osteophytes. Liver toxicity may occur with chronic use of etretinate. A 3-year, 20-patient prospective study failed to demonstrate increased hepatotoxicity in high-risk patients treated with etretinate (61). However, in a retrospective study of 18 patients taking etretinate for more than 5 years, 4 patients had mild to severe portal fibrosis defined by formation of septa extending into the lobule or cirrhosis (62). Most patients in this study did not have pretreatment liver biopsies.
Radiographic and Pathologic Features of Spinal Involvement in Diffuse Idiopathic Skeletal Hyperostosis *
Published in Alexander R. Vaccaro, Charles G. Fisher, Jefferson R. Wilson, 50 Landmark Papers, 2018
In this second of a two-part study by Resnick et al., the spinal radiographic and pathologic features of diffuse idiopathic skeletal hyperostosis (DISH) are described. Resnick et al. created the term DISH, previously labeled Forestier’s disease, in an earlier manuscript describing the extraspinal manifestations of the disease.1 This is the first study establishing diagnostic criteria for DISH, differentiating it from similar hyperostotic spine pathologies, for example, ankylosing spondylitis (AS) and intervertebral osteochondrosis or degenerative disc disease.
Isotretinoin for acne vulgaris – an update on adverse effects and laboratory monitoring
Published in Journal of Dermatological Treatment, 2022
Haady Fallah, Marius Rademaker
There are several non-controlled case series that document the development of hyperostoses or bony spurs on radiological examinations of patients treated with high dose isotretinoin (1 mg/kg/day or greater) (57–60). However, in each of these studies, the radiological findings did not correlate well with musculoskeletal symptoms. Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by entheseal ossification and/or calcification mainly involving the thoracic spine (61). It is a relatively common condition, especially in older individuals, making case reports of a possible association between isotretinoin and DISH difficult to interpret. In one study, the overall prevalence of DISH in the healthy population over the age of 50 years was 15% in women and 25% in men (62). DISH is more prevalent in developed nations and has been linked to metabolic syndrome (61).
Leopoli-Cencelle (9th–15th centuries CE), a centre of Papal foundation: bioarchaeological analysis of the skeletal remains of its inhabitants
Published in Annals of Human Biology, 2020
Marica Baldoni, Francesca Romana Stasolla, Giuseppina Scano, Luigi Tonino Marsella, Olga Rickards, Cristina Martínez-Labarga
In one individual (SU 5901) the pattern of lesions on the spine led to the differential diagnosis of Diffuse Idiopathic Skeletal Hyperostosis (DISH; Figure 6(b)). As reported in the literature, the manifestations of the disease include extensive hyperostosis at joint margins, muscular attachment sites, and particularly the vertebral column (Ortner 2003; Waldron 2019). In the latter, the presence of large bridging osteophytes and consequent vertebral fusion is generally limited in the thoracic region, mainly developing under the anterior longitudinal ligament (Ortner 2003). Although the observed pattern is not yet completely understood it has been hypothesised that the passage of the descending aorta on the left side of the thoracic vertebral bodies could be one of its determining causes (Ortner 2003; Waldron 2019). The complete record of pathological dental and skeletal lesions detected in the analysed individuals is reported in Supplementary Table 2 and 3, respectively.
Walking backwards into the future: the need for a holistic evolutionary approach in Pacific health research
Published in Annals of Human Biology, 2018
Elizabeth Matisoo-Smith, Anna L. Gosling
Because most other forms of metabolic disease primarily affect soft tissues, it is nearly impossible to detect them in skeletal assemblages. However, it has been observed that diffuse idiopathic skeletal hyperostosis (DISH) often co-occurs with metabolic diseases such as type 2 diabetes, obesity, hypertension, hyperinsulinemia, dyslipidemia and hyperuricaemia (Nascimento et al. 2014). Given that DISH has been identified among prehistoric Māori (Buckley et al. 2010), this is suggestive that metabolic disease more broadly may also have antiquity in the region.