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Selected Functional Foods That Combat the Effects of Hyperglycemia and Chronic Inflammation
Published in Robert Fried, Richard M. Carlton, Type 2 Diabetes, 2018
Robert Fried, Richard M. Carlton
The nature of this phenomenon, which could provide novel approaches to understanding the well-known beneficial health effects of tea phenols, is investigated in this study, and it was found that selected polyphenols displayed affinity for all of the selected cell nuclear structures. Theaflavin-digallate was shown to display the highest affinity for DNA reported for any naturally occurring molecule reported so far. This finding may have implications for understanding the role of tea phenolics as “life span essentials” (Mikutis, Karaköse, Jaiswal et al. 2013a).
Selected Functional Foods That Combat Inflammation
Published in Robert Fried, Lynn Nezin, Evidence-Based Proactive Nutrition to Slow Cellular Aging, 2017
The nature of this phenomenon, which could provide novel approaches for understanding the well-known beneficial health effects of tea phenols, is investigated in this study which found that selected polyphenols displayed affinity for all of the selected cell nuclear structures. Theaflavin-digallate was shown to display the highest affinity for DNA of any naturally occurring molecule reported so far. This finding may have implications for understanding the role of tea phenolics as “life span essentials” (Mikutis et al. 2013a).
Antibacterial Effect of Green Tea and Black Tea Extract Against Selected Genera of Bacteria
Published in Anne George, Oluwatobi Samuel Oluwafemi, Blessy Joseph, Sabu Thomas, Sebastian Mathew, V. Raji, Holistic Healthcare, 2017
K. A. Treasa Nimy, Vincent Terrence Rebello, T. K. Mukundan
Shetty et al.6 reported that the green tea extracts inhibited the growths of diarrhea causing S. aureus, S. epidermidis, V. parahaemolyticus, C. jejuni and V. cholera. Antibacterial activity of tea polyphenols against C. botulinum was studied by Yokihiko and Watanabe.7 They found C. botulinum spores were killed when inoculated into tea drinks. Horiuchi et al2 examined the bactericidal activity of tea and catechins against B. pertussis. Green tea, black tea and coffee showed marked bactericidal activity at their concentrations in beverages, while puerh tea killed the bacteria in a moderate way. This study suggest that green tea, black tea, epigallocatechin gallate (EGCG) and theaflavin digallate (TF3) might act as prophylactic against pertussis infection.
Regulatory mechanisms of exopolysaccharide synthesis and biofilm formation in Streptococcus mutans
Published in Journal of Oral Microbiology, 2023
Ting Zheng, Meiling Jing, Tao Gong, Jiangchuan Yan, Xiaowan Wang, Mai Xu, Xuedong Zhou, Jumei Zeng, Yuqing Li
Second messenger c-di-AMP and Ap4A regulate S. mutans biofilms formation. Inhibitors targeting synthetase/hydrolase or receptor proteins can affect the intracellular levels or signaling transduction of second messengers and inhibit biofilm formation. Currently, most c-di-AMP inhibitors target PDE and DisA [126]. For example, three inhibitors of Bacillus subtilis DisA, bromophenol-TH, suramin, and the tea polyphenol theaflavin digallate, were identified [126]. Stress alarmone ppGpp could competitively inhibit B. subtilis GdpP (PDE) [127]. However, inhibitors targeting S. mutans DAC/PDE still need further investigation. The mechanisms of action of these inhibitors and whether there might be an impact on the other flora in the oral cavity are still unclear.
Recent advances towards natural plants as potential inhibitors of SARS-Cov-2 targets
Published in Pharmaceutical Biology, 2023
Zhouman He, Jia Yuan, Yuanwen Zhang, Runfeng Li, Meilan Mo, Yutao Wang, Huihui Ti
In MD experiments, Mhatre et al. (2021) found that EGCG binds tightly to 3CLpro, PLpro, RdRp, spike RBD, and RBD-ACE2 of SARS-CoV-2. Compared with the RdRp inhibitors remdesivir and favipiravir, EGCG and theaflavin digallate have higher binding affinities for RdRp than remdesivir and favipiravir.