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Glove Selection for Work with Acrylates Including Those Cured by Ultraviolet, Visible Light, or Electron Beam
Published in Robert N. Phalen, Howard I. Maibach, Protective Gloves for Occupational Use, 2023
Cyanoacrylate adhesives or glues contain esters of cyanoacrylic acid and rapidly polymerize in the presence of moisture in the air or on a surface but involve less crosslinking than other acrylate-based adhesives.1 They are more commonly recognized as quick-bonding “instant adhesive” or “super glue.” They are also used in surgery and for wound-care products,1 such as Liquid Skin® and Dermabond®. Several recent cases of cyanoacrylate allergy have been reported in association with cosmetology (e.g., false eyelashes and press-on nails), as well as medical use of Dermabond®.71
Scalp, facial and gunshot injuries
Published in Helen Whitwell, Christopher Milroy, Daniel du Plessis, Forensic Neuropathology, 2021
Fracture lines may be seen radiating from the entrance hole. Secondary fractures occur as a result of raised intracranial pressure. As with other head injuries, these are most commonly seen in the orbital plates. Temporary cavitation will also produce secondary fractures. When the skull has been damaged after death, reconstruction of the skull with superglue will allow identification of an entrance wound.
Patch-Clamp Recording in Brain Slices
Published in Avital Schurr, Benjamin M. Rigor, BRAIN SLICES in BASIC and CLINICAL RESEARCH, 2020
Gluing the Tissue Block to the Slicing Stage — This is one stage of the preparation which can be a little tricky and seems to improve with practice. The stage of the slicer must be clean and any moisture from condensation dried off immediately before applying the glue (standard fast-drying, cyanoacrylate glue, e.g., Superglue®, UHU®). It is important not to use too much glue as this tends to form a loose unstable base, but rather enough to cover an area a little larger than the base of the brain to be glued with a thin, fairly even film of glue. The brain should then be picked up on a spatula with the side to be glued facing down and slipped off so that it lands directly onto the patch of glue. It should then be covered immediately with ice-cold solution. The time out of solution should be as short as possible (e.g., 6 seconds). Note that the brain does not need to be blotted dry. Although some people prefer to do this, we find it just increases the time during which the brain warms up out of solution. In the event that the brain falls off during slicing, it should be put back into the beaker of cold solution as quickly as possible and the stage of the slicer thoroughly cleaned and dried before applying new glue. This regluing often works, but seldom more than once. As the experimenter becomes more experienced the brain falls off less often, and eventually this becomes a rare event.
Cosmetics and Personal Care Products-Related Ocular Exposures Reported to United States Poison Control Centers
Published in Ophthalmic Epidemiology, 2022
Alisha Kamboj, Henry A. Spiller, Alexandra R. Funk, Jaahnavi Badeti, Gary A. Smith
Among product subcategories accounting for at least one percent of exposures, the greatest proportion of moderate or major effects was observed among exposures to acrylic nail adhesives. Nail glue, which is also marketed as false eyelash glue, is typically composed of a combination of alcohol, cyanoacrylate, and photo-bonded methacrylate.22 When this product makes contact with the eye, rapid polymerization of cyanoacrylate with subsequent formation of long chains may occur and cause bonding at the eyelid margin (resulting in a tarsorrhaphy-like appearance of the eyelids) or at the outer ocular structures (resulting in conjunctival or corneal abrasions and/or inflammation). In a review of the literature on superglue ocular injuries, some cases were managed conservatively, allowing the glue to detach from the eye over a period of days, while others received therapies such as irrigation, trimming of eyelashes and surgical separation of the lids, and mechanical removal of the glue; topical antibiotics and cycloplegics were also utilized in certain cases.23 In an investigation of ocular exposures to nail glue treated in US emergency departments, the primary mechanism of injury was identified as nail glue being mistaken for eye drops, representing more than one-fifth of all cases, followed by the product splashed into the eye and rubbed into the eye. Inadvertent ocular instillation of nail adhesive may result from similarities in the size, shape, and opening mechanism of nail adhesive bottles and eye drops bottles.24,25
Spectroscopy of Oxygen-Sensitive Material for Measuring Contact Lens Oxygen Transmissibility
Published in Current Eye Research, 2019
Phillip Dixon, Keith Christopher, Nina Jovic, Anuj Chauhan
A hole-puncher was used to punch a 4.5 mm hole into the bottom of a 5 mL eye drop bottle. Aluminum foil was then glued to the curved surface of the eye drop bottle to decrease oxygen transmission through the bottle material. Super glue was placed in the ring-shaped trough in the 3D-printed cap seen in Figure 1. Then, the contact lens was placed on the center of the 3D-printed cap so that the center of the contact lens was overlaying the 4.5 mm opening. Since only a part of the contact lens is exposed to the air, the calculated transmissibility will represent the average value for the region that was exposed. The bottle was then placed onto the cap, sandwiching the lens in between the two pieces. The glue was left to dry for 1 h. An additional line of glue was placed on the side at the meeting point between the 3D-printed cap and eye drop bottle to further ensure a good seal.
Drug distribution along the cochlea is strongly enhanced by low-frequency round window micro vibrations
Published in Drug Delivery, 2021
Samuel M. Flaherty, Ian J. Russell, Andrei N. Lukashkin
Lucifer yellow CH, lithium salt (Thermo Fisher Scientific) was used to visualize diffusion in straight water filled pipes (Figure 2). The pipes with an approximate length of 40 mm were constructed using Tygon™ LMT-55 tubing (1.14 mm ID, 0.80 mm wall, Fisher Scientific). An outlet (O, Figure 2) was made with a 25 G needle and inserted through the pipe’s wall close to one end and fixed in place with superglue. A membrane (M, Figure 2), cut from a laboratory latex glove (typical thickness of 0.1 mm), was glued with superglue at the same pipe end making sure that the glue does not cover the open surface of the membrane. The other pipe end was closed with a Blu Tack (Blue-tack.co.uk) plug (B1, Figure 2) to prevent water evaporation and a 25 G needle (N, Figure 2) was inserted through the plug into the pipe to provide pressure relief. The outlet was used to fill the pipe with deionized water to a distance of about 30 mm from the latex membrane and to inject 0.2 µl of 5% Lucifer yellow water solution into the pipe using a pipette. The outlet was closed with a Blu Tack (Blue-tack.co.uk) plug (B2, Figure 2) after the Lucifer yellow injection. Lucifer yellow fluorescence was excited using a 470 nm laser source (Dragon Lasers, Changchun Jilin, China) and still images were taken (Sony α6100 camera, Sony Macro E 30 mm F/3.5 lens) through an optical band pass filter (FB540-10, Thorlabs Inc.) to assess dye diffusion over time. The same miniature loudspeaker K16-50 Ohm (Visaton GmbH, Haan, Germany) with the carbon probe attached as used for the RW stimulation was employed to vibrate the latex membrane in assisted diffusion experiments. The carbon probe touching the membrane was pushed slightly toward inside of the pipes at rest to ensure membrane tension and its relaxation during backward phase of probe strokes. Fluorescence intensity profiles were measured along the pipe axis using Fiji open source image processing package.