China
Africa
Explore chapters and articles related to this topic
Marine Polysaccharides in Pharmaceutical Applications
Published in Se-Kwon Kim, Marine Biochemistry, 2023
Riyasree Paul, Sourav Kabiraj, Sreejan Manna, Sougata Jana
Chitosan and PEG were cross-linked with silver NPs using glutaraldehyde to treat wounds in diabetes induced wounds. The wound healing effect was determined using diabetic rabbits. Compared to chitosan-PEG based hydrogels, the developed hydrogel exhibited higher swelling and higher porosity. It also reported enhanced microbial efficacy. Sustained release of silver NPs was observed over 7 days (Masood et al. 2019). Zhao et al. developed conductivity promoting hydrogel dressing to be used for self-healing application of wounds. The modified chitosan grafted polyaniline hydrogel formulation exhibited anti-oxidative and anti-infection properties. It also demonstrated blood clotting ability at a certain cross-linker ratio. The study reports suggested considerable wound healing ability (Zhao et al. 2017). Pereira et al. reported the fabrication of a chitosan-polyethylene glycol–based matrix containing zinc oxide, calcium phosphate and copper oxide. An improved mechanical property was also reported. The addition of chitosan resulted in a bacteriostatic effect without producing any cytotoxicity (Pereira et al. 2019).
An Insight into Advanced Nanoparticles as Multifunctional Biomimetic Systems in Tissue Engineering
Published in Harishkumar Madhyastha, Durgesh Nandini Chauhan, Nanopharmaceuticals in Regenerative Medicine, 2022
Kusha Sharma, Abhay Tharmatt, Pooja A Chawla, Kamal Shah, Viney Chawla, Bharti Sapra, Neena Bedi
Microscale scaffolds cannot effectively replicate the ECM atmosphere, so nanoscale scaffolds such as nanofibres are being studied widely to develop heart tissue constructs. Both synthetic and natural polymers (e.g., collagen, protein, and fibrinogen), synthetic polymers [e.g., poly(lactide), poly(glycolide)], and their copolymers [(PLGA), poly(ε-caprolactone), poly(ethylene-co-vinyl alcohol)] are being spun into nanofibres using electrospinning (Cao et al., 1997). In a study, nanofibres were fabricated using biodegradable non-woven poly(lactide)- and poly(glycolide)-based (PLGA) platforms for cardiac TE applications (Zong et al., 2005). The results suggested that the nanofibrous construction of the matrix permitted the cardiomyocytes to use external hints for isotropic or anisotropic growth. The cardiomyocytes also interacted with the surrounding nanofibrous network to shape their growth to follow the scaffold-prescribed direction. Similarly, a nanofibrous assembly comprised of poly(l-lactic acid) and polyaniline, designed for cardiac TE, was described to show better biocompatibility and a significant outcome on cell differentiation while improved cellular distribution, arrangement, and cell–cell interactions (Wang et al., 2017).
Order Martellivirales: Virgaviridae
Published in Paul Pumpens, Peter Pushko, Philippe Le Mercier, Virus-Like Particles, 2022
Paul Pumpens, Peter Pushko, Philippe Le Mercier
Niu et al. (2006, 2007a, b) exploited the outer TMV surface as template to coat conductive polymers, namely polyaniline or polypyrrole, on the 1D assembled TMV to produce composite nanofibers and macroscopic bundles of such fibers as conductive nanowires. The nanomechanical properties of the polyaniline-coated TMV were evaluated by Wang et al. (2008). In parallel, the TMV-based materials demonstrated great potential with applications in nanoelectronics and energy-harvesting devices (Kalinin et al. 2006; Tseng et al. 2006; Miller et al. 2007).
A sensitive electrochemical immunosensor based on poly(2-aminobenzylamine) film modified screen-printed carbon electrode for label-free detection of human immunoglobulin G
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2018
Thitirat Putnin, Watthanachai Jumpathong, Rawiwan Laocharoensuk, Jaroon Jakmunee, Kontad Ounnunkad
To further enhance the biosensor performance, the electrode is subjected to surface modification by conducting polymers. In particular, polyaniline, one of most important conducting polymers has emerged as an intriguing material because of their specific redox properties, low cost, ease of production and good electrical conductivity along with their excellent biocompatibility [22,23]. In this work, poly(2-aminobenzylamine), a polyaniline derivative, was selected for electrode fabrication in the proposed immunosensor, because 1) poly(2-aminobenzylamine) provides selective detection of biomolecules as reported in the previous article using surface plasmon resonance [24] and 2) poly(2-aminobenzylamine) is easy to manipulate in terms of the deposition and formation rate of the polymer during electropolymerization [24]. In addition, the amino group (-NH2) in the poly(2-aminobenzylamine) structure acts as if it was a chemical scaffold for antibody to immobilize through amide bond on poly(2-aminobenzylamine) thin film. This renders stable analytical platform and high loading of antibody, which immensely boost up the analytical performance that will maximize the number of immunoreaction events. To the best of our knowledge, poly(2-aminobenzylamine) used for biosensing application has never been reported.
Synergistic effects of polyaniline and pulsed electromagnetic field to stem cells osteogenic differentiation on polyvinylidene fluoride scaffold
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2019
Ali Mirzaei, Ehsan Saburi, Seyed Ehsan Enderami, Matineh Barati Bagherabad, Seyedeh Elnaz Enderami, Mahmood Chokami, Abbas Shapouri Moghadam, Reza Salarinia, Abdolreza Ardeshirylajimi, Vahid Mansouri, Fatemeh Soleimanifar
Using this method, several polymers can be used to fabricate scaffold. At the present study, polyvinylidene fluoride (PVDF) has selected to make scaffold based on its prepared nanofibres biocompatibility and also its piezoelectricity that are useful for BTE according to the similarity to the bone tissue characteristics [9,10]. In addition, to increase the conductivity of the fabricated scaffold, polyaniline (PANI) as the most famous conductive polymer has also selected to composite with PVDF [11].
Development and characterization of a novel conductive polyaniline-g-polystyrene/Fe3O4 nanocomposite for the treatment of cancer
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2019
Lida Ahmadkhani, Ebrahim Mostafavi, Samaneh Ghasemali, Roghayeh Baghban, Hamidreza Pazoki-Toroudi, Soodabeh Davaran, Javad Malakootikhah, Nahideh Asadi, Lala Mammadova, Siamak Saghfi, Thomas J. Webster, Abolfazl Akbarzadeh
The electrical conductivity of polyaniline and its composites makes it suitable for electrical applications. Conductivity measurements were carried out by a four-point probe method. The blends of PANI nanocomposites were compacted into pellets for measurement. All measurements were done in air at room temperature and converted to conductivity by the following equation: