China
Africa
Explore chapters and articles related to this topic
Magnetically Controlled Targeted Chemotherapy
Published in Neville Willmott, John Daly, Microspheres and Regional Cancer Therapy, 2020
One of the important characteristics of an ideal targetable drug delivery system is its ability to traverse the target tissue endothelium and release the included chemotherapeutic agent at cellular and/or subcellular level.19,20 Indeed, it is also essential that the pharmacodynamic characteristics of the drug are not altered at any stage prior to reaching the target cells.13 Although some studies have suggested the possibility of extravascular transport of submicron drug carriers through the vasculature of malignant tumor tissue due to their increased permeability,45 from the therapeutic’s standpoint, extremely small fractions of the administered dose of drug carrier ever reaches the target tissue interstitium. Even with monoclonal antibody-based delivery systems, the peak drug concentrations in tumor tissue are rarely 2- to 3-fold higher than the surrounding normal tissues.46 In most instances the majority of carrier-delivered drug or macromolecular-conjugated drug is efficiently removed by the RES. Contrary to this standard in vivo deposition pattern, magnetic drug delivery systems offer unique characteristics in that they minimize drug carrier uptake by RES, facilitate its extravasation across the target tissue vasculature, and thus increase the probability of intracellular or third-order drug targeting.19,43,45,47,48
Effect and mechanism of paclitaxel loaded on magnetic Fe3O4@mSiO2-NH2-FA nanocomposites to MCF-7 cells
Published in Drug Delivery, 2023
Yun Ni, Peng Deng, Ruitong Yin, Ziye Zhu, Chen Ling, Mingyi Ma, Jie Wang, Shasha Li, Ruijiang Liu
Currently, new dosage forms of PTX mainly include emulsions (Li et al., 2022a), micelles (Abdallah et al., 2020), precursor drugs (Al-Hilfi & Walker, 2022), inclusion compounds, liposomes (Duan et al., 2022), nanoparticles (Gulsu et al., 2022; Chen et al., 2022b; Li et al., 2022c), and drug-releasing scaffolds (Obayemi et al., 2020). PTX nanoemulsion has many advantages, such as improved therapeutic effects, reduced side effects, maintained drug activity, and enhanced cell uptake and biological activity; however, their effectiveness and safety remain to be confirmed. Liposomes and micelles are promising drug carriers; however, their targeting, stability, and encapsulation efficiency remain to be improved (Alavi & Nokhodchi, 2022). The Cyclodextrin inclusion complex provided a feasible scheme for the oral preparation of PTX. The synthesis of precursor drugs is a complicated and expensive process, and their pharmacodynamics and pharmacokinetic properties may change unexpectedly. Regarding PTX preparation, nanoparticles have the advantages of high drug loading, large specific surface area, significantly increasing water solubility and reduced toxic and side effects (Fu et al., 2022; Gulsu et al., 2022; Sakhi et al., 2022). Magnetic nanodrug delivery systems have attracted increasing attention because of their good biocompatibility and multifunctional carrying capacity. Magnetic iron oxide nanoparticles have been applied to magnetic drug delivery systems by many researchers owing to their perfect preparation technology and good biocompatibility (Işıklan et al. 2022).
Magnetic nanoparticles: multifunctional tool for cancer therapy
Published in Expert Opinion on Drug Delivery, 2023
Sumera Khizar, Eslam Elkalla, Nadia Zine, Nicole Jaffrezic-Renault, Abdelhamid Errachid, Abdelhamid Elaissari
Anti-cancer drugs delivered to targeted sites are one of the effective methods used to treat cancer, along with fewer adverse effects. Nanoparticles have emerged as new generation multi-functional control tools at the micro-/nano-level. A more effective method is the functionalization of Nano-vehicles with target molecules. These functional moieties assist in the interaction of nanoparticles with particular receptors present in specific tumors, permitting their attachment to the tumor [1,2]. Another encouraging approach is magnetic cancer therapy, which is intended to improve imaging-guided delivery and therapeutic action [3]. Magnetic cancer therapy can be employed to treat various types of tumors, in which magnetic drug delivery vehicles are manipulated by applying a strong magnetic field [4].
Current trends in chemical modifications of magnetic nanoparticles for targeted drug delivery in cancer chemotherapy
Published in Drug Metabolism Reviews, 2020
Ahmad Gholami, Seyyed Mojtaba Mousavi, Seyyed Alireza Hashemi, Younes Ghasemi, Wei-Hung Chiang, Najmeh Parvin
In this review, MNPs were investigated for effective cancer therapy, including targeted drug delivery and hyperthermia agents. MNPs were highly recommended for novel cancer therapies over modern methods due to their superior properties and fewer side effects on the human body. The main advantages of MNPs (organic or inorganic) are that they can be: (i) visualized (superparamagnetic nanoparticles are utilized in MRI); (ii) target-hunting or held in place using a magnetic field; and (iii) heated during a magnetic field to trigger drug unleash or to provide hyperthermia/ablation of tissue. It is necessary to indicate that the latter capability is not restricted to MNPs, but additionally to different nanoparticles capable of absorbing near-infrared, microwave, and ultrasound radiations. Magnetic drug delivery constitutes a promising technology to treat cancer, and several other producers are already on the market. The restrictions inherent within the use of external magnetic fields will (in some cases) be circumvented using internal magnets placed within the proximity of the target by minimally invasive surgery. Magnetic fluid hyperthermia/thermal ablation is additionally promising and is presently being applied, however, is restricted by the fact that the tumor must be localized. This route, therefore, cannot be utilized in preventive medicine, or for treating early-stage tumors. However, it is a promising path for future researches to ultimately accomplish the high potential of MNPs in medical specialty fields.