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Case studies (2006–2020)
Published in Stephen Verderber, Ben J. Refuerzo, Innovations in Hospice Architecture, 2019
Stephen Verderber, Ben J. Refuerzo
The Hisa Hospic is located on the slope of Golovec Hill, at the edge of an urban district in proximity to Ljubljana city center. Its site environs are wooded, with few nearby buildings and the structure is sited adjacent to Hradeckega Road, a busy thoroughfare. The site overlooks a river, and a hillside slopes dramatically upward immediately behind the hospice. It is buffered from the busy roadway by means of a perimeter wall; a gate and sidewalk provide access from a parking area near the main entrance. The gate provides access from the road, accentuated by a concrete panel-sign inscribed with the word HOSPIC in bold letters. Compositionally, a cubic volume functions as the point of departure. This three-level cube is articulated by means of a checkerboard grid of alternating grey and reddish-orange rectangles. The overall effect is striking in both its simplicity, elegance, and for being memorable without becoming self-referential (Figure 6.8.1).
Neural Control of Renal Function*
Published in Irving H. Zucker, Joseph P. Gilmore, Reflex Control of the Circulation, 2020
Ulla C. Kopp, Gerald F. DiBona
There has been substantial debate concerning the role of a adrenoceptors in the control of neurally mediated renin secretion. Whereas there is little doubt that the increase in renin secretion rate produced by renal nerve stimulation at intensities causing marked decreases in urinary sodium excretion and renal blood flow is partly related to activation of vascular and/or tubular a adrenoceptors (Kopp et al., 1981; Osborn et al., 1982b; Hisa et al., 1985), the role of a adrenoceptors in the increase in renin secretion rate produced by renal nerve stimulation at intensities causing minimal renal hemodynamic changes has been controversial. Early studies by Blair (1981) showed that the increase in renin secretion rate produced by low-level renal nerve stimulation was inhibited by α-adrenoceptor antagonists when renal arterial pressure was controlled at 80–90 mmHg, i.e., 30–40 mmHg below spontaneous arterial pressure. However, these findings were not confirmed by other investigators who examined renin secretion responses to low-level renal nerve stimulation in the absence and presence of α-adrenoceptor antagonists at spontaneous renal arterial pressure (Osborn et al., 1982b; Osborn and Johns, 1989). More recent studies by Blair et al. (1985) have confirmed that the differences in the results between her initial studies and those of others (Osborn and Johns, 1989) were related to the level of renal arterial pressure and could be explained by an interaction between the neural and nonneural mechanisms regulating renin release that is dependent on the intensity of renal nerve stimulation and the level of renal arterial pressure (vide infra). Furthermore, a recent study in conscious rats demonstrated that the increase in plasma renin activity following administration of the α2-adrenoceptor antagonist yohimbine was a secondary consequence of a generalized increase in sympathetic nervous system activity (Pfister and Keeton, 1988).
Information technology (IT)
Published in Nassab Reza, Rajaratnam Vaikunthan, Loh Michael, B. Sonny Bal, Applying MBA Knowledge and Skills to Healthcare, 2017
Nassab Reza, Rajaratnam Vaikunthan, Loh Michael, B. Sonny Bal
When moving between hospitals, clinicians will notice significant differences in the software used for patient records and imaging. In order to allow ready exchange of information between the various systems some standards must exist.3➤ ASTM CCR – Continuity of Care Record – A patient health summary standard based upon XML, the CCR can be created, read and interpreted by various EHR or EMR systems, allowing easy interoperability between otherwise disparate entities.➤ ANSI X12 (EDI) – Used for transmitting virtually any aspect of patient data. Has become popular in the United States for transmitting billing information.➤ CEN – EN13606 – the European standard for the communication of information from EHR systems, and HISA, a services standard for inter-system communication in a clinical information environment.➤ DICOM – A heavily used standard for representing and communicating radiology images and reporting.➤ HL7 – HL7 messages are used for interchange between hospital and physician record systems and between EMR systems and practice management systems; HL7 Clinical Document Architecture (CDA) documents are used to communicate documents such as physician notes and other material.➤ ISO – ISO TC215 has defined the EHR, and also produced a technical specification ISO 18308 describing the requirements for EHR architectures.➤ Open EHR – public specifications and implementations for EHR systems and communication, based on a complete separation of software and clinical models.
Regulate and Communicate: Associations between Emotion Regulation and Sexual Communication among Men with Hypoactive Sexual Desire Disorder and their Partners
Published in The Journal of Sex Research, 2023
Grace A. Wang, Serena Corsini-Munt, Justin P. Dubé, Erin McClung, Natalie O. Rosen
The Hurlbert Index of Sexual Assertiveness (HISA; Hurlbert, 1991) was used to assess how frequently participants assert themselves sexually (e.g., “I speak up for my sexual feelings”; reverse coded) and experience discomfort or reluctance when communicating about their sexual relationship (e.g., “I feel uncomfortable telling my partner what feels good”). Participants rated 25 items on a scale from 0 (all the time) to 4 (never). Total scores ranged from 0 to 100, with higher scores indicating greater levels of sexual assertiveness. The HISA has been previously validated and shown to have good reliability and construct validity (Hurlbert, 1991; Pierce & Hurlbert, 1999). It was conceptualized as a single factor (Hurlbert, 1991) and prior studies consistently used its total score (e.g., Lyons et al., 2022; Pierce & Hurlbert, 1999; Wongsomboon et al., 2022). Cronbach’s alphas for the current sample were .89 for men with HSDD and .91 for partners.
Alkyl rhamnosides, a series of amphiphilic materials exerting broad-spectrum anti-biofilm activity against pathogenic bacteria via multiple mechanisms
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2018
Guanghua Peng, Xucheng Hou, Wenxi Zhang, Maoyuan Song, Mengya Yin, Jiaxing Wang, Jiajia Li, Yajie Liu, Yuanyuan Zhang, Wenkai Zhou, Xinru Li, Guiling Li
It has been observed that 12C-Rha significantly disturbed biosynthesis/metabolism of amino acids, owing to the results that six proteins (Rpe, SerA, CysE, GLYCTK, MmuM and HutI) related to biosynthesis/metabolism of amino acids pathways were under-expressed in treated biofilm cells. Since more complex amino acids are needed in biofilm cells [37], the disordered amino acid balance in S. aureus caused the un-proper formation and disruption of biofilm. As to carbohydrate metabolism related proteins, five proteins (MtlD, FruK, PTS-Gat-EIIA, Rpe and TarJ) were downregulated in 12C-Rha treated biofilm cells. That is, the energy production highly required in biofilm formation and maintenance was limited by 12C-Rha. In the contrary, we could also notice that several proteins (such as: HisA, TPI, PGAM and GpmI) related to biosynthesis/metabolism of amino acids pathways and several proteins (such as: GalM, RbsK and ManA) related to carbohydrate metabolism were over-expressed in treated biofilm cells, which might be explained by the normal stress response of S. aureus to 12C-Rha. In addition, seven proteins (MutS, UvrD, RecJ, Ssb, DPO3A1, RecG and RecD) mapped to mismatch repair and homologous recombination were changed differently (up or down), this might indicate that 12C-Rha also took some effects on S. aureus DNA.
Assesment of hematotoxic, oxidative and genotoxic damage potentials of fipronil in rainbow trout Oncorhynchus mykiss, Walbaum
Published in Toxicology Mechanisms and Methods, 2021
Arzu Uçar, Veysel Parlak, Aslı Çilingir Yeltekin, Fatma Betül Özgeriş, Özge Çağlar, Hasan Türkez, Gonca Alak, Muhammed Atamanalp
In the present study, FP administration led to reductions in erythrocyte count and hemoglobin value. This indicates anemia or severe bleeding. Anemia is caused by conditions such as a reduction in the number or size of erythrocytes, malnutrition, cell destruction or deterioration of hemoglobin structure (Hisa and Connie 1998). Besides, the decrease in the number of erythrocytes results in a decrease in the hematocrit value. Changes in hematological parameters may be attributed to forming a small number of erythrocytes due to inhibition, destruction, hypoxia of hemosynthesis or erythropoiesis (Ullah et al. 2019). The decrease in erythrocyte count and hemoglobin amount may be due to the mechanism of pesticide damage to erythropoietic tissue as a result of the destruction of erythrocytes (Seth and Saxena 2003). In the present study, leukocyte count was decreased in low and high dose fipronil groups but increased in 0.1 mg/L group. This increase in leukocytes shows the hypersensitivity of the cells to FP insecticide. This change may result from the immunological responses of the fish to produce more leukocyte cells induced by FP. The hormetic response is found in the organism’s overcompensation to a disruption in homeostasis. If this is the case, then any agent that can disrupt homeostasis (i.e. cause toxicity) would be expected to induce a hormetic response to the damage induced. In FP groups, the decrease observed in platelets shows that the blood is thinner. However, it can be an indicator of the mechanism and physiological suitability of platelet reduction and indication of damage in tissues involved in blood production (Qureshi et al. 2016).