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Fenugreek
Published in Dilip Ghosh, Prasad Thakurdesai, Fenugreek, 2022
Ujjwala Kandekar, Sunil Ramdasi, Prasad Thakurdesai
Gold nanoparticles are being explored for numerous applications such as cancer treatment, diabetes, Parkinson’s disease, and coronary disease (Pallotta et al. 2019). However, the gradual degradation of catalytic activity on multiple usage limits the monometallic nanoparticles to industrial applications (Mallikarjuna et al. 2019). The incorporation of aqueous extract of fenugreek seeds (0.5 to 3 ml) in the gold nanoparticles formulation was effectively used as a reducing and protecting agent in the catalytic formulation of stable and spherical nanoparticles (Aswathy Aromal and Philip 2012). The presence of flavonoids in fenugreek extract is suggested as a reducing agent and capping material, whereas protein can contribute to the stabilization of nanoparticles (Aswathy Aromal and Philip 2012).
Anti-HSV and Cytotoxicity Properties of Three Different Nanoparticles Derived from Indian Medicinal Plants
Published in P. Mereena Luke, K. R. Dhanya, Didier Rouxel, Nandakumar Kalarikkal, Sabu Thomas, Advanced Studies in Experimental and Clinical Medicine, 2021
K. Vasanthi, G. Reena, G. Sathyanarayanan, Elanchezhiyan Manickan
Synthesis of gold nanoparticles was done as described previously by Tiwari (2011). Briefly, lyophilized powder of Plant extracts were reconstituted with 1 ml of sterile distilled water and mixed with 0.002 M of chlororauric acid (SRL Cat. No) (HAuCl4) in dark conditions with a preincubation at 90°C. After incubation the color of the solution were turned its color to ruby pink (Figure 13.2) indicates the gold nanoparticle formation. According to Klaus (2001) synthesis of silver Nanoparticles was done. Briefly, lyophilized powder of plant extracts were reconstituted with 1 ml of sterile distilled water and mixed with 20 ml of 10−3 M AgNO3 (SRL Cat. No: Cat. No for (HAuCl4)-12023, Cat. No for (AgNO3) – 94118) (99.99%) aqueous solution and kept at room temperature. After 1 hour the color of the solution were changed from colorless to honey brown (Figure 13.2) indicating the formation of silver nanoparticles and this is confirmed by UV-visible spectroscopy and other methods. Synthesis of bimetallic nanoparticles (Silver-Gold) were done according to the Pal et al. Briefly, lyophilized powder of plant extracts were reconstituted with 1 ml of sterile distilled water and mixed with equal amount of 10−3 M AgNO3 and 0.002 M of chlororauric acid and incubated at room temperature. After incubation the color of the solution were turned its color in the combination of ruby pink and honey comb color (Figure 13.2).
Toxicity and Cellular Uptake of Gold Nanoparticles: What We Have Learned So Far *
Published in Valerio Voliani, Nanomaterials and Neoplasms, 2021
Alaaldin M. Alkilany, Catherine J. Murphy
Gold nanoparticles have attracted enormous scientific and technological interest due to their ease of synthesis, chemical stability, and unique optical properties. Proof-of-concept studies demonstrate their biomedical applications in chemical sensing, biological imaging, drug delivery, and cancer treatment. Knowledge about their potential toxicity and health impact is essential before these nanomaterials can be used in real clinical settings. Furthermore, the underlying interactions of these nanomaterials with physiological fluids is a key feature of understanding their biological impact, and these interactions can perhaps be exploited to mitigate unwanted toxic effects. In this Perspective we discuss recent results that address the toxicity of gold nanoparticles both in vitro and in vivo, and we provide some experimental recommendations for future research at the interface of nanotechnology and biological systems.
Monoclonal antibody as a targeting mediator for nanoparticle targeted delivery system for lung cancer
Published in Drug Delivery, 2022
Nasrul Wathoni, Lisa Efriani Puluhulawa, I Made Joni, Muchtaridi Muchtaridi, Ahmed Fouad Abdelwahab Mohammed, Khaled M. Elamin, Tiana Milanda, Dolih Gozali
Gold nanoparticles (AuNP) are an example of nanocarriers exhibiting favorable size, shape, stability, and biocompatibility. Gold nanoparticles’ adjustable surface and distance-dependent optical properties reveal their enormous potential to be used in a variety of scientific domains (Wang et al., 2019). Due to their surface charge or potential zeta value, gold nanoparticles have been used as drug carriers, supported by their physicochemical properties, stability, and incorporation into cellular processes, as well as their further accumulation. The level of toxicity assigned to AuNPs is highly dependent on the surface charge of the particles, with positively charged gold nanoparticles causing cell death at much lower concentrations, while neutrally charged particles cause cell death at much higher concentrations (Corsi et al., 2020).
Green synthesis and characterization of gold nanoparticles from Pholiota adiposa and their anticancer effects on hepatic carcinoma
Published in Drug Delivery, 2022
Zhongwei Yang, Zijing Liu, Junmo Zhu, Jie Xu, Youwei Pu, Yixi Bao
The FT-IR spectra of PAP-1a and its binding efficiency to AuNPs are shown in Figure 4. A. This result demonstrated the presence of multiple functional groups. The peaks observed for the PAP-AuNPs at 3443.09 and 1636.92 cm−1, which were correspondingly assigned to the free O-H and C=C stretching modes, could arise from the PAP-1a. Chemical, electrochemical, and photolytic reduction techniques are the most prevalent ways of the reduction of gold nanoparticles (Pestov et al., 2016). The reduction involved functional groups, such as hydro sulfonyl (–SH) and aldehyde group (–CHO) (Zhang et al., 2019). The FT-IR analysis of PAP-AuNPs revealed a peak at 1636.92 cm−1, indicating the presence of esters compounds and maybe revealing the underlying mechanisms of PAP-1a that bring about the reduction of chloroauric acid to PAP-AuNPs. The EDAX result depicted the elemental composition of PAP-AuNPs (Figure 4(B)) indicating the presence of Au, C, and O, which presumably aid in the effective synthesis of PAP-AuNPs.
Boosting the anti-inflammatory effect of self-assembled hybrid lecithin–chitosan nanoparticles via hybridization with gold nanoparticles for the treatment of psoriasis: elemental mapping and in vivo modeling
Published in Drug Delivery, 2022
Salma A. Fereig, Ghada M. El-Zaafarany, Mona G. Arafa, Mona M. A. Abdel-Mottaleb
Owing to their various advantageous properties, gold nanoparticles have been a rich research material for scientists in the field of drug delivery over the few past years. In fact, they were proven to be very good candidates for dermal drug delivery. In addition to their small size, optical properties, and ease of surface functionalization, they also possess anti-inflammatory properties (Uchiyama et al., 2014; Arafa et al., 2018), without exhibiting cytotoxic effects especially when prepared by green methods and tailored in terms of size and concentration (Bessar et al., 2016; Perde-Schrepler et al., 2016; Nemati et al., 2017; Crisan et al., 2018). All of which are attributes that make gold nanoparticles beneficial for the treatment of inflammatory skin diseases like psoriasis, a chronic autoimmune-mediated inflammatory condition with genetic predisposition.