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Cancer Drugs and Treatment Formulations for Women-Associated Cancers
Published in Shazia Rashid, Ankur Saxena, Sabia Rashid, Latest Advances in Diagnosis and Treatment of Women-Associated Cancers, 2022
Reetika Arora, Pawan K. Maurya
Nanoparticles offer the added benefit of increasing the solubility of medicines, reduced dosage and toxicity, improved cellular absorption, and so forth. Because of their tiny size, these are rapidly absorbed by tumour cells and efficiently encapsulate hydrophobic molecules. The other benefits of nanotechnology in cancer treatment include precise medication targeting via active or passive targeting, reduced systemic toxicity, controlled-release drug delivery, the ability to mix several medicines for successful therapy, better bioavailability of the cancer drug, and so on. The US Food and Drug Administration (FDA) has authorized nanomaterials for diagnosis and treatment of breast cancer. Thus, nanotechnology seems to be way forward for future cancer trials and treatment.
Emerging Technologies for Particle Engineering
Published in Dilip M. Parikh, Handbook of Pharmaceutical Granulation Technology, 2021
Nanotechnology is the science and technology at the nanoscale, which is about 1 to 100 nanometers and it can be used across the entire spectrum of scientific fields including life sciences and healthcare [2] The prefix “nano” means 10‒9, or one-billionth and is about a thousand times smaller than a micron. Depending on the atom, approximately three to six atoms can fit inside of a nanometer. Nanoparticles possess many special physical, chemical, and biological properties. They have found applications in diverse fields, including materials synthesis and processing, dispersions and coatings, fuel cells and sensors, biotechnology and health effects, energy and environment, instruments and probes, and studies of fundamental transfer processes. Recent developments in nanoscience, combining physics, chemistry, material science, theory, and biosciences, have brought us to another level of understanding of “nanotechnology.” The systems provide methods for targeting and releasing therapeutic compounds in very defined regions. These vehicles have the potential to eliminate or at least ameliorate many problems associated with drug distribution. Below 100 nm, materials exhibit different, more desirable physical, chemical, and biological properties. Given the enormity and immediacy of the unmet needs of therapeutic areas such as CNS disorders, this can lead to drugs that can extend the life and save untimely deaths [3].
Anti-HSV and Cytotoxicity Properties of Three Different Nanoparticles Derived from Indian Medicinal Plants
Published in P. Mereena Luke, K. R. Dhanya, Didier Rouxel, Nandakumar Kalarikkal, Sabu Thomas, Advanced Studies in Experimental and Clinical Medicine, 2021
K. Vasanthi, G. Reena, G. Sathyanarayanan, Elanchezhiyan Manickan
Nanotechnology is an emerging area in pharmaceutical and medical field. Physicochemical and biological properties of materials would be varying fundamentally from their bulk part at their nanometric scale; this is due to the size-dependent quantum effect. The nanoparticles such as gold and carbon are surface-functionalized, have unique dimensions, and controlled drug release, thus can be used in the drug delivery [20–22]. On this basis the present study was highlighted the use of nanotechnology in the synthesis of drug from the medicinal plants and their effect against herpes virus.
Comprehensive review on use of phospholipid based vesicles for phytoactive delivery
Published in Journal of Liposome Research, 2022
Manish Kumar Gupta, Vipul Sansare, Birendra Shrivastava, Santosh Jadhav, Prashant Gurav
Nanotechnology is an interdisciplinary area of research and development associated with the production, processing, and utilization of materials having a nanometer size range (Patra et al.2018). Furthermore, nanotechnology in the herbal drug domain has been investigated to improve the bioavailability of phytoconstituents. In recent decades, noble attention has been paid to the use of nanotechnology-based looms for the development of herbal novel drug delivery systems (NDDS) (Wang et al.2013). Clear, strong, and well-documented evidence supports the concept of herbal actives loaded NDDS (Wang et al. 2014). Extensive research and investigations in the field of herbal NDDS came up with successful designs of herbal actives encapsulated NDDS (Devi et al.2010). Numerous phospholipid based vesicles like liposomes, phytosomes, ethosomes (Abdulbaqi et al.2016), transfersomes glycerosomes (Manconi et al.2018), santosomes (Apolinário et al.2021), glycethosomes (Pleguezuelos-villa et al.2020) and hyalurosomes (Manca et al.2019) were successfully utilized for effective delivery of plant extracts/isolated phytoconstituents (Bonifácio et al.2014).
Colorectal cancer management: strategies in drug delivery
Published in Expert Opinion on Drug Delivery, 2022
Prabha Singh, Pramita Waghambare, Tabassum Asif Khan, Abdelwahab Omri
Application of nanotechnology for drug delivery has the potential to bring about a huge impact in preventive, therapeutic, and diagnostic advancement of medicine. Nanoparticles have the ability to enhance the stability, solubility of drugs loaded as well as increase permeation across membranes, provide opportunity for active, passive and site-specific drug targeting. Nanoparticles have shown promising results in vitro and in small animal models. Despite this there are few products commercially available for patients indicating a transitional gap. This could be due to the lack of understating of pathological and physiological differences between experimental animal models and humans and its impact on the function of nanomedicines in vivo. Also, heterogeneity among patients could be a contributing factor limiting clinical translation of delivery systems [123]. Another challenge to clinical translation is the cost of production due to the complexity of the process as compared to conventional dosage forms. Other major hurdles include biological challenges, safety, large scale production, government regulations, intellectual property, and biocompatibility leading to slower clinical translations of nanomedicines [124].
Prophylactic effect of probiotics fortified with Aloe vera pulp nanoemulsion against ethanol-induced gastric ulcer
Published in Toxicology Mechanisms and Methods, 2021
Jihan Hussein, Mona A. El-Bana, Mehrez E. El-Naggar, Yasmin Abdel-Latif, Samah M. El-Sayed, Dalia Medhat
Based on all aforementioned data,nanotechnology may provide important benefits to medicine including selective drug delivery to specific tissues. Recently, nanomedicines showed positive approaches in improving of drug solubility, reducing off-target side effects, and offer innovative protective and therapeutics tools (El-Sayed et al. 2019). Encapsulation technologies including nanoemulsions showed marked improvement in the solubility of oils and biologically active elements. In addition, studies on the development of encapsulation techniques’ and physical characterization showed effective and promising results. Nanoemulsion technology achieves an increase in the variability of food processes, preservation from oxidation or depletion, and ultimately, improved food bioactivity (Zhong et al. 2018).