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Perspective on Microspheres in Regional Cancer Therapy
Published in Neville Willmott, John Daly, Microspheres and Regional Cancer Therapy, 2020
Neville Willmott, Bruce Gray, John Daly
Clearly, as a first approximation, it is desirable to incorporate as much active agent as possible within the microsphere matrix consistent with a degree of sustained release. Although high drug loading may lead to premature release and unacceptably high systemic concentrations of incorporated agent, preliminary data using radiolabeled doxorubicin incorporated into cation exchange resin microspheres indicate that this is not always the case (Chen, Burton, and Gray, personal communication).
Distribution
Published in Paul Pumpens, Single-Stranded RNA Phages, 2020
Further improvement of the RNA phage monitoring was succeeded by the introduction of a novel concentration technique for their enumeration from 10-liter volumes of ambient surface waters such as lake, river, and marine and river water with varying turbidities (McMinn et al. 2017b). An anion-exchange resin was employed for the FRNA phage concentration in diverse water types (Chandler et al. 2017a). Application of the anion-exchange resin was elucidated before with the phages MS2, Qβ, and GA as models (Pérez-Méndez et al. 2014). An extensive review of the concentration techniques was published recently by Dincau et al. (2017).
Separation Of The Bound And Unbound Forms Of The Radioactivity
Published in Erwin Regoeczi, Iodine-Labeled Plasma Proteins, 2019
A detailed discussion of the reasons of anion-exchange resin selectivity is beyond the scope of this book. It is enough to note here that several factors seem to be involved apart from electrostatic forces. One of these is the polarizability of the anion in the field of the resin cation.12 Chu et al.13 emphasize the importance of ion solvation; according to them, there is a tendency of large univalent ions to be forced out of a dilute solution and into the resin phase because of their small degree of hydration and considerable water-structure- breaking character.
A novel anti-NGF PEGylated Fab’ provides analgesia with lower risk of adverse effects
Published in mAbs, 2023
Yukari Koya, Hirotsugu Tanaka, Eiji Yoshimi, Nobuaki Takeshita, Shuji Morita, Hiroki Morio, Kanako Mori, Hiroshi Fushiki, Masazumi Kamohara
To introduce PEG into the Fab’, the Fab’ fragment was reduced using 1 mmol/L Tris (2-carboxyethyl) phosphine hydrochloride (TCEP HCl) in 20 mM sodium phosphate buffer (pH 6.8) for 2 hours at 37°C, and then diluted with 20 mmol/L sodium acetate buffer (pH 5.0). This solution was adsorbed onto a cation exchange resin and eluted using a NaCl gradient solution. The obtained Fab’ fragment was diluted with 20 mmol/L sodium phosphate buffer (pH 6.8) and left overnight or longer at 4°C to naturally oxidize. PEG of size 40 kDa (SUNBRIGHT GL2-400 MA, NOF Corporation) was added and the solution was incubated for 2 hours at room temperature followed by overnight at 4°C. The solution was diluted with 20 mmol/L sodium acetate buffer (pH 4.5) and adsorbed again onto a cation exchange resin and eluted using a NaCl gradient solution to purify the PEGylated Fab’ fragment. The weights reported here include the weights of both the protein (Fab’) and PEG.
Current and potential treatment options for hyperphosphatemia
Published in Expert Opinion on Drug Safety, 2018
Fabio Carfagna, Lucia Del Vecchio, Giuseppe Pontoriero, Francesco Locatelli
Sevelamer hydrochloride is a calcium- and metal-free phosphate binder. It acts as an anion exchange resin, binding to phosphate by exchanging it for chloride ions, and is not absorbed from the gastrointestinal tract [34]. Sevelamer carbonate is a more recent formulation, with similar efficacy to the hydrochloride form but a lower risk of metabolic acidosis [35,36]. In addition to binding phosphate, sevelamer also binds bile acids in the intestinal tract and reduces serum levels of low-density lipoprotein cholesterol (LDL-C) and can improve inflammation and possibly hyperuricemia and hyperglycemia [37]. Sevelamer also binds liposoluble vitamins, such as vitamin D and K [38,39] and may reduce levels of immunosuppressants, such as mycophenolate mofetil, and also cyclosporine metabolites [40].
Acute intermittent porphyria: general aspects with focus on pain
Published in Current Medical Research and Opinion, 2018
John Lidemberto Cardenas, Carlos Guerrero
The available detection methods are the Watson–Schwartz test, a rapid screening method for urinary PBG, or the column method of Mauzerall and Granick, a quantitative and more specific test. However, these tests have been replaced by easier and more specific methods, such as the Trace PBG kit that uses an anion exchange resin. The detection tests for PBGD mutations have a sensitivity and specificity of 95% and 100%, respectively, and are increasingly being used. The newer tests are not recommended for the general population given the large number of mutations, unless a mutation has been identified in a family or in a population with a high rate of genetic carriers3,10,18.