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Liquid Biopsies for Pancreatic Cancer: A Step Towards Early Detection
Published in Surinder K. Batra, Moorthy P. Ponnusamy, Gene Regulation and Therapeutics for Cancer, 2021
Joseph Carmicheal, Rahat Jahan, Koelina Ganguly, Ashu Shah, Sukhwinder Kaur
One of the significant reason for poor prognosis of pancreatic cancer is the unavailability of highly sensitive and specific early detection markers. Since the pancreas is a vital metabolic organ of the body, identification and classification of its physiologic versus pathological metabolic signatures seem a logical pursuit for PC biomarker discovery. Since an altered metabolome significantly reflects the changing phenotypic status of an individual over time, metabolomics has emerged as a promising readout for differentiating high-risk benign groups including type 2 diabetes mellitus and chronic pancreatitis from pancreatic cancer cases. Table 2 enlists the recent significant studies that have identified crucial metabolites for PC detection.
Identification of the Dead
Published in Michael J. Thali M.D., Mark D. Viner, B. G. Brogdon, Brogdon's Forensic Radiology, 2010
In mass disasters, which in practical terms means having more bodies than can be handled by the facility available to those charged with making the identifications, all the tech-niques discussed previously may need to be employed. More pertinent, the organization and management of the personnel involved with the recovery of the remains and their identification are among the most important aspects of pro-cessing multiple dead bodies. All professionals with expertise in the various aspects of scene investigation and body identification must work as a team. Plans, practice, and patience are necessary ingredients in assuring that these hor-rendous tasks are accomplished efficiently. With multiple deaths, extreme care and caution must be exercised at the scene by those charged with the recovery. In airplane crashes and/or bombings, where great forces not only shred the remains into small pieces but also scatter them over broad areas, the investigators must meticulously chart which remains were found where and carefully label them accordingly, both to assist in the identification and also to assist in reconstructing the event. Where body parts are commingled, the assistance of the anthropologist becomes all important.
‘SI VIS VITAM, PARA MORTEM’ terror management theory and psychosocial healthcare practice
Published in Social Work in Health Care, 2019
Within the context of this article, health-related cues (i.e., blood tests, visits to a medical clinic, and consuming medicaments) are to be interpreted as MS cues, thus they may have a differential impact on body-related perceptions and behaviors, depending upon degrees of body identification and body esteem. However, current theoretical and empirical literature does not yet provide us with sufficient evidence we can rely upon in recommending any practical implications that identification and esteem play in the presence of a medical related MS cue. Would patients, high in both body identification and body esteem comply more with medical recommendations and invest more in required life style regimes in comparison to patients high in body identification but low in body esteem? What can TMT predict as to adherence and body investment among patients with low body identification? Would their responses to MS cues differ in accordance with their levels of body esteem?