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Biobased Products for Viral Diseases
Published in Mahendra Rai, Chistiane M. Feitosa, Eco-Friendly Biobased Products Used in Microbial Diseases, 2022
Gleice Ribeiro Orasmo, Giovanna Morghanna Barbosa do Nascimento, Maria Gabrielly de Alcântara Oliveira, Jéssica Missilany da Costa
In this chapter, bioproducts obtained from extracts or molecules isolated from plants, or even from other organisms, are addressed. These have been listed as antivirals, presenting findings in literature regarding their effects and potential use in treatments for various viral diseases, as well as, in the discovery of future new drugs.
Introduction
Published in Joanna Ziarkowska, Indigenous Bodies, Cells, and Genes, 2020
These processes redirect emphasis from bodies to molecular levels of analysis, a shift that is also announced in the title of this book and which involves reconceptualizing agency, personhood, illness identities, and embodiment. It is not only a new perspective on bodies, tissues, cells, and genes that biomedicalization generates, but also their commodification into bioproducts in a bioeconomy of desired objects of study in the burgeoning research on human genome and DNA sequencing. These concerns about genomic research are particularly relevant to Indigenous people who first of all object to the often illicit practices of obtaining their DNA samples, and, second, fear that the knowledge produced from such projects, rarely negotiated with Indigenous epistemologies, will be used to challenge tribal sovereignties.
Potential of Herbal Extracts and Bioactive Compounds for Human Healthcare
Published in Megh R. Goyal, Hafiz Ansar Rasul Suleria, Ramasamy Harikrishnan, The Role of Phytoconstitutents in Health Care, 2020
Ramasamy Harikrishnan, Chellam Balasundaram
WHO reports that medicinal plants are the ideal source to develop novel drugs [13]. The traditional use of plants and their bioproducts began since time immemorial in the form of folk medicine; and over time, its application has also been extended into allopathic medicine [233]. Today, a number of herbs for use as traditional and folk medicine continue to explore further understanding and to document their potentials, protection, and effectiveness with modern tools of research. Indeed since antiquity, the pharmacological bioproperties of various herbs were documented; they possess antimicrobial secondary metabolites, such as: alkaloids, amides, glycosides, essential oils, flavonoids, furostanol, phytosterols, spirostanol, saponins, steroids, tannins, terpenoids, etc. which are utilized against infectious pathogens [69, 79, 288, 309, 386, 433, 487, 723, 970]. Many herbal medicines possess immunomodulatory, antibacterial, and antimicrobial activities [206, 271, 717, 972].
Voriconazole incorporated nanofiber formulations for topical application: preparation, characterization and antifungal activity studies against Candida species
Published in Pharmaceutical Development and Technology, 2020
İmren Esentürk, Timuçin Balkan, Gül Özhan, Sibel Döşler, Sevgi Güngör, M. Sedef Erdal, Abdulkadir Sezai Sarac
VCZ was obtained from Mylan Laboratories (Hyderabad, India). Polyvinyl alcohol (PVA, molecular weight of 89 000–98 000, 99% hydrolyzed) and SA from brown algae (medium viscosity) were purchased from Sigma Chem Co. (St. Louis, MO, USA). GTA solution (25%, aqueous solution) was obtained from Sigma Chem Co. (St. Louis, MO, USA). The mouse fibroblast cell culture (BALB/3T3) and Candida albicans ATCC 10231 were provided by American Type Culture Collection (ATCC® CLL-163TM, Manassas, VA, USA). Dulbecco’s modified Eagle’s medium (DMEM) was purchased from Sigma Chem Co. (St. Louis, MO, USA). Fetal bovine serum (FBS) was purchased from Gibco, Paisley, UK. Cell culture media was purchased from Wisent Bioproducts (St. Bruno, QC, Canada), and sterile plastic materials were purchased from Greiner (Frickenhausen, Germany). Triton X-100, RPMI-1640 medium, and morpholinepropanesulfonic acid (MOPS) were obtained from Sigma (Sigma-Aldrich, St Louis, MO, USA). Candida albicans ATCC 10231 was provided by American Type Culture Collection (ATCC® CLL-163TM, Manassas, VA, USA). Deionized water was supplied from Merck Millipore Milli-Q ultrapure water system (Merck Millipore, Molsheim, France). All other chemicals and reagents were of analytical grade and used without further purification.
Strategies for recombinant production of antimicrobial peptides with pharmacological potential
Published in Expert Review of Clinical Pharmacology, 2020
Kamila Botelho Sampaio de Oliveira, Michel Lopes Leite, Gisele Regina Rodrigues, Harry Morales Duque, Rosiane Andrade da Costa, Victor Albuquerque Cunha, Lorena Sousa de Loiola Costa, Nicolau Brito da Cunha, Octavio Luiz Franco, Simoni Campos Dias
Like gramicidin, many of these natural molecules exert activity against bacteria and other pathogens, including viruses, protozoans, and fungi. Therefore, they are suitable candidates not only for the development of alternative antibiotics but also for new antifungals, antivirals, and antiprotozoals [18]. They have certain advantages when compared to conventional antibiotics, such as a lower risk of resistance, broad-spectrum activity, less toxicity, synergy with other compounds and rapid death [20]. Natural AMPs also have immunomodulatory activity, resulting in inhibition of inflammatory response, stimulation of proliferation and recruitment of macrophages, neutrophils, eosinophils, and T lymphocytes [20]. Furthermore, they can present anticancer activities [22,23]. These qualities make them attractive candidates for the advancement of other drugs besides alternative commercial bioproducts.
Biological detoxification of ochratoxin A in plants and plant products
Published in Toxin Reviews, 2019
Mahmoud Sheikh-Zeinoddin, Mohammadreza Khalesi
Demands for bioproducts obtaining from the biochemical process are increasing. As an ancient green process, fermentation is an easy, fast and cost-effective process used to preserve the nutritional value, flavor, aroma, and texture of the food products, and to control several environmental pollutions (Bourdichon et al. 2012, Ghimire et al. 2015, Lee et al. 2015, Sen et al. 2016). Yeasts, particularly Saccharomyces cerevisiae, and LAB are the main groups of the microbial population involved in food and beverage fermentation (Jespersen 2003). The raw materials involved in the fermentation process are suspicious to be contaminated by the fungal mycotoxins like OTA (Riba et al. 2008). Nevertheless, following an ideal fermentation process usually results in the OTA-free products (Halász et al. 2009, Hathout and Aly 2014). This attributes to the OTA decontamination by the starters. It is a challenging issue to correlate this OTA detoxification whether to LAB, to yeasts, or probably both (Halász et al. 2009).