China
Africa
Explore chapters and articles related to this topic
Calcium Phosphate and Bioactive Glasses
Published in Vincenzo Guarino, Marco Antonio Alvarez-Pérez, Current Advances in Oral and Craniofacial Tissue Engineering, 2020
Osmar A. Chanes-Cuevas, José L. Barrera-Bernai, Iñigo Gaitán-S., David Masuoka
There is a need for new biomaterials that can substitute damaged tissues, stimulate the body’s own regenerative mechanisms and promote tissue healing. Porous templates referred to as ‘scaffolds’ are thought to be required for three-dimensional tissue growth. Bioceramics, a special set of fully, partially or non-crystalline ceramics (e.g., calcium phosphates, bioactive glasses and glass-ceramics) that are designed for the repair and reconstruction of diseased parts of the body, have high potential as scaffold materials. Traditionally, bioceramics have been used to fill and restore bone and dental defects (repair of hard tissues). More recently, this category of biomaterials has also revealed promising applications in the field of soft-tissue engineering. Therefore, the use of bioceramics in biomedical applications is on the increase.
Bio-Ceramics for Tissue Engineering
Published in Naznin Sultana, Sanchita Bandyopadhyay-Ghosh, Chin Fhong Soon, Tissue Engineering Strategies for Organ Regeneration, 2020
Hasan Zuhudi Abdullah, Te Chuan Lee, Maizlinda Izwana Idris, Mohamad Ali Selimin
Biomaterials are very important in biomedical applications for replacement, construction and repairing hard tissue and soft tissue purposes. Biomaterials can be classified into biometal, bioceramic, biopolymer and biocomposite. Bioceramics have got more attention for bone reconstruction and as an implant especially for hard tissue (bone). The properties of bioceramics were altered depending the specific application in the human body. It can be in various form and structure such as porous, dense and combination of them. In this chapter, metal oxide ceramic (gel oxidation of titanium, i.e. TiO2), glass ceramic (Bioactive glass) and ceramic (hydroxyapatite) were discussed in association with bioactive properties and reaction with the natural bone. In vitro testing (simulated body fluid (SBF) and cultured cell (osteoblast)) were performed to study the bioactive properties and prediction of in vivo reaction of bioceramics. The preparation, mechanism and biological reactions are investigated and analysed to get the information for potential use in biomedical applications. The analysed results from the in vitro testing show the suitability of bioceramics (bioactive) for substituting or repairing hard tissue (bone).
Bioceramic Nanoparticles for Tissue Engineering
Published in Harishkumar Madhyastha, Durgesh Nandini Chauhan, Nanopharmaceuticals in Regenerative Medicine, 2022
Knowing the fact that nanoparticles have the significant ability to improve well-established cell biocompatibility approaches, the use of bioceramic nanoparticles in tissue engineering have shown magnificent development. Since nanoparticles can be fabricated with different shapes, sizes, and with versatile functionality, various composite materials and scaffolds have been developed employing the platform of ceramic-based nanoparticles. These nanoparticles have been successfully utilised for developing 3D-based dense and porousfibres, hydrogels, and implants used for orthopaedic and dental tissue engineering applications, but they can be appropriately used for a wide variety of other necessary biomedical applications. Ongoing research involves the utilisation of these nanoparticles for enhancing the properties of tissue engineering scaffolds by altering the chemistry, composition, and structure of the composite materials. These biomimetic modifications in scaffold properties can help in delivering the sequential release of biological agents or growth factors in a manner that not only helps in improving the mechanical integrity upon implantation, but also in providing suitable porosity for tissue-specific reactions. Although till date, there has been a significant increase in scientific interest and subsequent studies focusing on bioceramic nanoparticles used in engineering new tissue, the concerns about the safety of these nanoparticles for clinical applications have not been addressed. Therefore, additional consistent and comprehensive research is required to ensure nanoparticle’s innocuousness and convert the present studies into a viable strategy, which can be used for human health applications. The strategies should be devoted to the clear understanding of mechanical strength for long-term service under external stress, the reproducibility of well-characterised nanoparticles, bioceramic-tissue interactions, and their ultimate fate in the body. Thus, in the future, one can expect the development of new and superior scaffolds and implants, which will provide a strong toolbox and open up new avenues for future tissue engineering applications.
Use new poly (ε-caprolactone/collagen/NBG) nerve conduits along with NGF for promoting peripheral (sciatic) nerve regeneration in a rat
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2018
Forouzan Mohamadi, Somayeh Ebrahimi-Barough, Mohammad Reza Nourani, Akbar Ahmadi, Jafar Ai
In ensuring the success of neural tissue engineering, material selection plays a decisive role as specified by Ezra et al. [7]. By tailoring the material degradation rates and mechanical features, it is possible to reduce the inflammatory response, thus improving the guidance and support to preserve axon regeneration [8]. Poly (ε-caprolactone)(PCL) as a synthetic material in combination with a natural polymer of collagen are attractive as neural tissue engineering conduits to obtain a scaffold with favorable cell adhesion, tailored degradation rate, appropriate mechanical and surface properties [9]. On the other hand, bioceramics are usually used combined with different polymers to obtain the best possible biological and mechanical properties. The characteristics of nanobioglasses (NBG) include excellent bioactivity, ability to deliver cells and controllable biodegradability to release ions during the degradation process [10]. While bioactive glasses have been used widely for bone regeneration, little research has been done on the application of bioactive glasses to the regeneration of soft tissues, peripheral nerve regeneration [3]. Also, recent studies indicate that low concentrations of 45S5 bioactive glass induce angiogenesis, which is necessary for multiple applications in tissue regeneration and the healing of soft tissue wounds [11].
Combined use of bulbar conjunctival pedicle flap and labial mucous membrane graft for porous orbital implant exposure: Long-term outcome
Published in Orbit, 2018
Kent Chow, Khami Satchi, Alan A. McNab
Twenty three patients were included in the study. Twenty two (96%) of them had a coralline hydroxyapatite implant, and one a bioceramic (aluminium oxide) implant. The mean follow-up was 130 ± 75 months (range 29–267 months). Table 1 summarizes the characteristics of the study population. Table 2 describes the individual patient data of the study population. All seven patients with motility pegs developed implant exposure immediately adjacent to the peg. Only two of these seven patients required BoneSource® hydroxyapatite cement to fill in residual implant hole intraoperatively. Sixteen patients (70%) received a scleral patch graft as part of their operation. No intraoperative complications were noted in any patient.
A New Procedure in Bone Engineering Using Induced Adipose Tissue
Published in Journal of Investigative Surgery, 2021
Randa Alfotawi, Mona Elsafadi, Manikandan Muthurangan, Abdul-Aziz Siyal, Musaad Alfayez, Amer A. Mahmmod
Using bioceramics in vivo as an osteoinductive material has been previously demonstrated.15 The cement used in this study was injectable bone cement, which consisted of 60% calcium sulfate, 40% hydroxyapatite powder, and a liquid phase composed of water and iohexol at a 1:0.5 ratio. Material characterization had been performed previously.17 Because of the exothermic reaction of the cement or tight crystal networking, the optimal time for cell seeding on similar material was found to be 15 min after cement injection into the extracellular matrix.17 Furthermore, the osteogenic potential had been optimized in a previous study, when bone marrow stromal cells (BMSCs) were seeded on the surface of the cement.17