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Advanced Cell Therapy for Asherman's Syndrome
Published in Carlos Simón, Carmen Rubio, Handbook of Genetic Diagnostic Technologies in Reproductive Medicine, 2022
Jordi Ventura, Xavier Santamaria
Finally, another interesting strategy for organ regeneration consists of using 3D bioprinting technologies, which could improve the functionality of tissue-engineered scaffolds by using an appropriate bio-ink and cell source (86–88).
Human organs, tissues and biological materials
Published in Gary Chan Kok Yew, Health Law and Medical Ethics in Singapore, 2020
In bioprinting, the stem cells are put into a bio cartridge together with proteins and other biological materials to generate living tissues.122 3D bioprinting of bioinks involve living cells (stem cell lines) and biomaterial scaffolds for growing these cells into tissues. Bioink refers to “biomaterial ink engineered to convey living cells through a printing process for the purpose of fabricating biological constructs” (Gilbert et al. 2018, at p. 74).
Craniofacial Regeneration—Bone
Published in Vincenzo Guarino, Marco Antonio Alvarez-Pérez, Current Advances in Oral and Craniofacial Tissue Engineering, 2020
Laura Guadalupe Hernandez, Lucia Pérez Sánchez, Rafael Hernández González, Janeth Serrano-Bello
Nowadays during the fabrication process of this technique, printing of cells, cell aggregates or growth factors into the bio-ink, deposited layer by layer, and subsequently crosslinked, having an effective control over scaffold fabrication and cell distribution, which is named as 3D bioprinting (Derakhshanfar et al. 2018; Sigaux et al. 2017).
The application of pancreatic cancer organoids for novel drug discovery
Published in Expert Opinion on Drug Discovery, 2023
Michael Karl Melzer, Yazid Resheq, Fatemeh Navaee, Alexander Kleger
Generation of many uniform organoids in a format suitable for high-throughput screening has always been challenging [105]. The utilization of bioprinting techniques allows to scale up the production of organoids and tissue constructs. In vitro models of tumors can be generated by assembling tumor organoids with various types of stromal cells using 3D bioprinting [106]. Tumor models employing 3D bioprinting can accurately mimic the microenvironment of tumors in an in vitro setting, and render useful for pre-clinical drug testing therefore enhancing the chances of successful translation into the clinic. The advancement of bioprinting technology, including hardware, software, bioinks, and printing protocols, could lead to larger tissue constructs and an increased number of micro-scaled tissue and tumor models. Specifically, the customization of bioinks with tunable stiffness and composition (e.g. fully synthetic ink functionalized with peptides, different collagens, or laminins, etc.) enhances the flexibility and versatility of bioprinting. Additionally, the exact geometrical positioning of cells in a reproducible manner allows for standardization and scalability in terms of throughput.
The most promising microneedle device: present and future of hyaluronic acid microneedle patch
Published in Drug Delivery, 2022
Huizhi Kang, Zhuo Zuo, Ru Lin, Muzi Yao, Yang Han, Jing Han
It is worth mentioning that the preparation of HA MNP is very time-consuming. This is the main reason to limit the large-scale use of HA MNP. Preparation methods such as micro-molding, laser cutting, photolithography (Lee et al., 2010), and wet and dry etching (Roh et al., 2022) have now been developed. But industrial production requires a more simple method. Recently, 3 D printing has been introduced as a powerful MNP fabrication strategy. Ouyang et al. (Ouyang et al., 2020) investigated bio-inks represented by MeHA, which can meet the physicochemical requirements of printing and provide an ideal environment for encapsulating cells. Petta D et al. summarized the recent research progress of HA-containing bio-inks for 3 D printing (Petta et al., 2020), giving us a lot of inspiration for choosing the right bio-ink to prepare HA MNP. We hope that in the future, we can find the perfect bio-inks for HA MNP printing.
Three-dimensional bioprinting of artificial ovaries by an extrusion-based method using gelatin-methacryloyl bioink
Published in Climacteric, 2022
T. Wu, Y. Y. Gao, J. Su, X. N. Tang, Q. Chen, L. W. Ma, J. J. Zhang, J. M. Wu, S. X. Wang
The emergence of three-dimensional (3D) printing technology has provided researchers with numerous strategies for creating prosthetic organs or tissues that are biocompatible, degradable and functional [17]. In recent years, 3D printing has demonstrated its potential in regenerative medicine, being used to create patient-specific beating hearts, distensile airways and central nervous system scaffolds [18–20]. With the advancement of 3D printing technology and cell biology, more versatile organs can be created using novel bioinks or in vitro methods. However, its application to female reproductive therapy is currently limited [21–23]. To date, 3D printed ovaries have only been attempted by Laronda et al. in 2017, who reported 3D fabrication of gonad tissues that partially restored ovarian function (i.e. hormone secretion and egg production) [21]. Accordingly, there is still much work to be done if such systems are to advance from experimental exploration to clinical application. Investigating 3D printing systems for bioengineering reproductive tissues is of paramount importance for in vitro culture of follicles, ovary tissue transplantation and menopausal hormonal therapy.