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Special Considerations for Men's Health
Published in Gia Merlo, Kathy Berra, Lifestyle Nursing, 2023
Advanced paternal age is not well defined for men. Most studies commonly define advanced paternal age as between 35 and 50 years of age. Advanced paternal age is associated with a decline in semen volume, total sperm count, progressive sperm motility issues, and abnormal sperm morphology. Lifestyle decisions about the age at which one pursues parenting are important for fertility.
The Genetic Risk of a Couple Aiming to Conceive
Published in Carlos Simón, Carmen Rubio, Handbook of Genetic Diagnostic Technologies in Reproductive Medicine, 2022
Joe Leigh Simpson, Svetlana Rechitsky, Anver Kuliev
Parental ages should always be recorded. Advanced maternal age confers increased risk of aneuploid offspring (4). Increased paternal age confers little increased risk for aneuploid offspring, although sperm with cytological abnormalities (e.g., breakage) may be associated with adverse pregnancy outcomes that result from defective DNA repair. The risk of a de novo single- gene mutation increases, as noted, with advanced paternal age. There is, however, no specific maternal or paternal age threshold beyond which a sperm or oocyte donor should categorically be excluded. Each reproductive medicine unit should develop and adhere to its own consistent policy.
Principles of Pathophysiology of Infertility Assessment and Treatment*
Published in Asim Kurjak, Ultrasound and Infertility, 2020
Joseph G. Schenker, Aby Lewin, Menashe Ben-David
Regarding the male partner, fecundability is maximal around the age of 24 to 30 years. The biological influence of paternal age in the decline of infertility is mainly due to the decline of his sexual activity in terms of the number of ejaculations per week and the time it takes to achieve erection. Some studies have found that advanced paternal age may cause an increase in the incidence of pregnancy loss mainly due to chromosomal aberrations. Several environmental factors like nutritional disturbances, stress, exposure to drugs, and chemical and physical agents may contribute to infertility.
The effect of paternal age on intracytoplasmic sperm injection outcome in unexplained infertility
Published in Arab Journal of Urology, 2021
Haitham Elbardisi, Mohamed Arafa, Neha Singh, Bridget Betts, Ashok Agrawal, Ralf Henkel, Alia A. Al-Hadi, Hasan Burjaq, Alia Alattar, Kareim Khalafalla, Ahmad Majzoub
The fact that advanced paternal age is associated with accumulation of genetic mutations, increased sperm diploidy, epigenetic changes and DNA breaks may have interfered with fertilisation and competency of embryo development and could be a possible explanation for a significant difference in fertilisation and cleavage rates between the study groups [34]. Our present study was well adjusted for all the known variables affecting implantation of the embryo and pregnancy outcomes like embryo quality [35], maternal age [36], endometrial thickness [37] and AMH [38], which might explain why we did not find any a significant difference in the CPR, MR and LBR between the two groups. Moreover, female age, which is a major determinant of fertilisation and implantation, was well controlled in our present study. However, the major limitation of our present study was its retrospective nature due to which we failed to assess some other variables affecting semen parameters like BMI, smoking, and endocrine factors such as thyroid status. Also due to our centre’s protocol, we did not perform blastocyst transfer; hence, we could not see the effect of the paternal genome in extended embryo culture to form the blastocyst.
Parental Age at Conception and the Relationship with Severity of Autism Symptoms
Published in Developmental Neurorehabilitation, 2020
Robert D. Rieske, Johnny L. Matson
The current study found no significant effects of maternal age at any level of the study; however, several statistically significant results were found in relation to paternal age. Father’s age was found to be a significant predictor of an autism diagnosis after controlling for other covariates (e.g., child’s age and gender). Father’s age was also found to be a significant predictor of autism severity scores in the final model which included child’s age, gender, and maternal age. While it is unclear based on the results of the current study, it is possible that maternal age connotes the risk for neurodevelopmental problems broadly based on previous research findings21,30 and may be the cause for no significant findings in this clinical sample. Additionally, it is unclear how paternal age may affect developmental risks and severity of symptoms. It is possible that paternal age connotes additional risks that could increase the severity of symptoms when combined with maternal and other risk factors. Results of the current study, however, are not sufficient to make such assumptions, but further research in this area may help to elucidate those factors and risks involved in advanced paternal age at conception.
Evolutionary life history theory as an organising framework for cohort studies: insights from the Cebu Longitudinal Health and Nutrition Survey
Published in Annals of Human Biology, 2020
Christopher W. Kuzawa, Linda Adair, Sonny A. Bechayda, Judith Rafaelita B. Borja, Delia B. Carba, Paulita L. Duazo, Dan T. A. Eisenberg, Alexander V. Georgiev, Lee T. Gettler, Nanette R. Lee, Elizabeth A. Quinn, Stacy Rosenbaum, Julienne N. Rutherford, Calen P. Ryan, Thomas W. McDade
These findings are important because they suggest that telomere length in any given generation is partially a reflection of the average age of reproduction among recent generations of male ancestors. Because the age at reproduction is a key life history parameter, this integrative quality of the paternal age at conception effect hints at a capacity to calibrate a dimension of maintenance expenditure in response to a signal of the likely ages of reproduction in that population (for a similar example involving nutrition, see Kuzawa 2005). Because longer telomere length allows cells to replace themselves more readily, longer telomere length is implicated as a cause of improved immune function, better wound healing, and improved cardiovascular function (likely due to improved blood vessel repairs). All of these cell replication-dependent processes are likely to be energetically expensive and from an LHT perspective longer inherited TL may thus be viewed as a cause of increased maintenance effort (Eisenberg 2011). Increasing allocation to somatic maintenance may thus be an adaptive shift in allocation priorities in demographic and cultural settings in which reproduction typically occurs later in life.