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The Parasite's Way of Life
Published in Eric S. Loker, Bruce V. Hofkin, Parasitology, 2023
Eric S. Loker, Bruce V. Hofkin
Eukaryotic parasites may also be transmitted via sexual contact. Trypanosoma equiperdum, the causative agent of dourine, a disease of equines, is an example. Another example is provided by Tritrichomonas foetus, a flagellated protozoan parasite that can cause serious disease in cattle. The parasite generally resides in the foreskin of bulls, in which symptoms are usually unapparent. When transferred to the female reproductive tract, however, it can cause uterine infection (pyometra), infertility and spontaneous abortion. In the past, this parasite imposed a large financial burden on the cattle industry. In recent years, the number of cases has declined as the use of artificial insemination has increased. Remarkably, however, it is now considered to be an emerging pathogen in cats, where it can cause chronic diarrhea. Unlike in cattle, it inhabits the intestinal tract and is excreted in the feces.
In vivo activity and atom pair fingerprint analysis of MMV665941 against the apicomplexan parasite Babesia microti, the causative agent of babesiosis in humans and rodents
Published in Pathogens and Global Health, 2023
Mohamed Abdo Rizk, Shimaa Abd El-Salam El-Sayed, Ikuo Igarashi
MMV665941 was also found to be effective against some strains of Perkinsus marinus, a major protozoal disease of oysters, however the efficiency was not uniform across all strains of the parasite [23]. Brugia malayi and B. pahangi, as well as Cryptosporidium, Tritrichomonas foetus trophozoites, and Trypanosoma cruzi, have all been proven to be susceptible to this chemical [24–27]. MMV665941 has a structural similarity to gentian violet. In addition to being utilized as a mold inhibitor in feed components, gentian violet has been employed in human medicine for illnesses with a variety of bacteria [28]. In the United States, however, gentian violet is strictly prohibited for use in any food animal [29]. Interestingly, there have been few grounds given for the gentian violet prohibition, other than the FDA’s statement that the impact of drug residues on human health has not been sufficiently studied [29].