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Prediction of Cervical Cancer Using Machine Learning
Published in Meenu Gupta, Rachna Jain, Arun Solanki, Fadi Al-Turjman, Cancer Prediction for Industrial IoT 4.0: A Machine Learning Perspective, 2021
Ashish Kumar, Revant Singh Rai, Mehdi Gheisari
Meiquan et al. (2018) [19] used a Faster R-CNN object detection framework, which was developed from R-CNN and Fast R-CNN. Using this, they were able to create an advanced neural network (ANN) that could in turn be used for detecting the target cells and further could be used for classification. Their model was adept at finding out about the five different types of target cells. The model gives a positive precision rate of 0.91. It gives accuracy of 78% for a two-class model, whereas the accuracy for a four-class model is 70%. They concluded that it could automatically diagnose a squamous intraepithelial lesion with good precision and reliability.
Gynecologic Cancers and Lifestyle Medicine
Published in Michelle Tollefson, Nancy Eriksen, Neha Pathak, Improving Women's Health Across the Lifespan, 2021
Nathalie D. McKenzie, Nnamdi I. Gwacham, Sarfraz Ahmad
The early natural history of HPV infection is negatively affected by smoking and the regression of low squamous intraepithelial lesion (LSIL) within 2 years has been found to be significantly lower in smokers than in nonsmokers.56 Roura et al.57 recently noted that women who stopped smoking for at least 10 years had half the risk of developing intraepithelial neoplasia and invasive cancer compared to women who continued smoking. Additionally, current smoking has also been associated with a 45% increase in the risk of disease progression and a 58% increase in the risk of death.58 Women diagnosed with invasive cervical cancer who are still smokers have an associated 35% increase in all-cause mortality and a 21% increase in cervical-cancer-specific mortality.59 It is thereby prudent to encourage the cessation of smoking during treatment for cervical cancer in an effort to abrogate the poorer prognosis that has been demonstrated among smokers.
Sexually Transmissible Viral Pathogens: Human Papillomaviruses and Herpes Simplex Viruses
Published in Attila Lorincz, Nucleic Acid Testing for Human Disease, 2016
Attila T. Lorincz, Jennifer S. Smith
The specific current clinical uses for HPV DNA testing include triage of patients with ASC-US diagnoses on their Pap tests; triage of low-grade squamous intraepithelial lesion (LSIL) Pap results in adolescent and post-menopausal women; resolution of discordant cytology–colposcopy-histology findings; follow-up after treatment for test of cure; follow-up after a negative or normal colposcopy; or population screening as an adjunct to the Pap test — effectively summarized in several seminal publications by Wright and others.22–24
Clearance of HR-HPV within one year after focused ultrasound or loop electrosurgical excision procedure in patients with HSIL under 30
Published in International Journal of Hyperthermia, 2022
Yi Qin, Qing Li, Xunyu Ke, Yan Zhang, Xiaoling Shen, Wenping Wang, Qiuling Shi, Chengzhi Li
Cervical cancer ranks second among malignant tumors as a lethal disease among women and poses a great threat to women’s health and life, with the morbidity increasing in younger populations [1]. A large number of studies have confirmed that persistent high-risk human papillomavirus (HR-HPV) infection is closely related to high-grade squamous intraepithelial lesion (HSIL) or cervical intraepithelial neoplasia grades 2–3 (CIN 2–3) and that HR-HPV is an important factor for the progression of CIN 2–3 to invasive cervical cancer [2]. Human papillomavirus (HPV) is a common sexually transmitted infection in life with the peak incidence observed among sexually active women [3]. The major peak of HPV infection occurs in women aged 26–30 years [4], who are more likely to be infected with the high carcinogenic types [5].
Factors Correlated with the Accuracy of Colposcopy-Directed Biopsy: A Systematic Review and Meta-Analysis
Published in Journal of Investigative Surgery, 2022
Hongyan Ren, Mengzhe Jia, Shujun Zhao, Hongyu Li, Suzhen Fan
In patients with negative colposcopy, random cervical biopsy can also help to find high-grade squamous intraepithelial lesions [53]. One study [54] has shown that random cervical biopsies were significant for the diagnosis of cervical lesions. Nam, K et al. found that the detection rate of the high-grade squamous intraepithelial lesion can be improved by random biopsies taken from the squamocolumnar junction of quadrants [55]. The precision was also decided by the number of biopsies taken [56]. Colposcopy-directed cervical biopsy sensitivity may improve when gynecologists performed more biopsies from colposcopy-directed unusual areas [11, 27, 42]. The sensitivity for detecting high-grade squamous intraepithelial lesion (HSIL) with a single biopsy (60.6%) is lower than with three biopsies (95.6%) [57]. Also, the size of the biopsies varies a lot in different countries. Some colposcopists prefer very small biopsies and often use a randomized way. Some prefer a little bit larger.
Lobular endocervical glandular hyperplasia mimicking cervical adenocarcinoma
Published in Journal of Obstetrics and Gynaecology, 2021
Felix Boria, Jaime Siegrist, David Hardisson, Nuria Saturio, Ignacio Zapardiel
The Pap smear showed a low-grade squamous intraepithelial lesion (LSIL) confirmed by a biopsy. The cervix was hypertrophic in vaginal US, with an increased vascularisation and multiple cysts in the posterior labia. The MRI revealed multiple grouped cysts versus multilocular cystic lesion located in an enlarged uterine cervix, encircling the cervical canal from the isthmus to the ectocervix and growing into the cervical stroma especially in the posterior labia, with measures of 40 × 50 × 45 mm (height × anteroposterior diameter × transverse diameter) [Figure 1]. The larger cysts partially surrounded the small cysts and this distribution resembled a ‘Cosmos Pattern’. No solid component or restricted diffusion areas were clearly identified within the lesion, however, moderate enhancement and slight irregular thickening of some of the cyst walls or septa could be observed. Radiologic diagnosis suggested LEGH as the best possibility, although minimal deviation adenocarcinoma (adenoma malignum) or, less likely, other benign conditions such as cystic cervicitis or multiple grouped Nabothian cysts could not be ruled out.