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Microorganisms, Plants, and Lower Animals
Published in Stephen P. Coburn, The Chemistry and Metabolism of 4′-Deoxypyridoxine, 2018
Bradner and Clark65 tested the effects of deoxypyridoxine, using filter paper discs, on anaerobic microorganisms as part of a search for a screening test for anticancer drugs. Bacteroides pseudoramosus was most susceptible to deoxypyridoxine inhibition showing inhibition at 10 gg deoxypyridoxine per disc. Clostridium acidi-urici, and Clostridium fesseri were somewhat susceptible showing inhibition at 100 gg/disc but not at 10. Bacteroides limosus, Butryibacterium rettgeri, Clostridium cylindrosporum, Micrococcus aerogenes and Propionibacterium freudenreichii were inhibited only at the highest concentration of deoxypyridoxine tested (1 mg/disc). Propionibacterium shermaniiwas not inhibited.
B-Group Vitamin-Producing Lactic Acid Bacteria
Published in Marcela Albuquerque Cavalcanti de Albuquerque, Alejandra de Moreno de LeBlanc, Jean Guy LeBlanc, Raquel Bedani, Lactic Acid Bacteria, 2020
Marcela Albuquerque Cavalcanti de Albuquerque, María del Milagro Teran, Luiz Henrique Groto Garutti, Ana Clara Candelaria Cucik, Susana Marta Isay Saad, Bernadette Dora Gombossy de Melo Franco, Jean Guy LeBlanc
Therefore, as previously discussed, an alternative to the consumption of synthetic vitamins as dietary supplements to improve nutrients intake and contribute to the management of nutritional deficiencies is the use of LAB as a cell factory to produce natural forms of different B-vitamins which can be used to formulate bio-enrich foods (Masuda et al. 2012, Albuquerque et al. 2016, Juarez del Valle et al. 2014). Many studies have focused on food bio-enrichment through the fermentation process, where food grade LAB are used to improve B-vitamin content of fermented products (Albuquerque et al. 2019, Yépez et al. 2019) and to improve B-vitamin status in vitamin-deficiency in vivo models. Thus, Laiño et al. (2015) used fermented milk bio-enriched with folates produced by LAB to improve the folate status in rodent’s depletion-repletion and complete deficiency models. The authors observed that the bio-enriched fermented milk was able to improve the folate status and prevent folate deficiency. Additionally, they proposed that bio-enriched fermented milk could improve the natural folate intake being consumed as part of the normal diet. LeBlanc et al. (2006) used Propionibacterium freudenreichii to produce riboflavin (B2) in a bio-enriched fermented milk. This fermented milk was administrated to riboflavin deficient rats and was able to improve their vitamin status eliminating most physiologic manifestations of ariboflavinosis. Juarez del Valle et al. (2016) also observed an improvement in the riboflavin status of deficient rats when these animals were fed with fermented soymilk bio-enriched with riboflavin produced by a strain of Lactobacillus plantarum.
Synergistic Cytotoxic and Apoptotic Effects of Local Probiotic Lactobacillus Brevis Isolated from Regional Dairy Products in Combination with Tamoxifen
Published in Nutrition and Cancer, 2021
Zahra Nasiri, Hamed Montazeri, Neda Akbari, Seyedeh Sara Mirfazli, Parastoo Tarighi
In Vivo and In Vitro experimentations have proved the antitumor activity of Lactobacillus on gastrointestinal cancers. Lactobacillus and bifidobacterium utilizing in fermented milk can reduce breast cancer risk (23). In this study, the direct effect of lactobacillus supernatant, alone and in combination with Tamoxifen was evaluated on MCF-7 breast cancer cell. The specific mechanism of probiotics effects on breast cancer is not clear, but developing immune functions associated with immune response, antiproliferative effects by regulation of apoptosis and suppressing carcinogen metabolites of pathogenesis are the basis of probiotics function (14). Previously, in 2012 Lee et al. demonstrated that the Short-chain fatty acids (SCFAs) produced by Propionibacterium Freudenreichii could induce apoptosis in colorectal cancer cells (24). We found that the Lactobacillus Brevis metabolites in supernatant decreased cell proliferation by inducing apoptosis in breast cancer cells and this growth inhibitory can influence Tamoxifen function in an unclear way.
Role of IgA in the early-life establishment of the gut microbiota and immunity: Implications for constructing a healthy start
Published in Gut Microbes, 2021
Jielong Guo, Chenglong Ren, Xue Han, Weidong Huang, Yilin You, Jicheng Zhan
The main difference in the GM of infants delivered via C-section is a decrease in Bifidobacterium, Lactobacillus, and bacterial diversity. Supplementation with mixed probiotics, including B. breve Bb99, Propionibacterium freudenreichii subsp. hermanii JS, L. rhamnosus Lc705, and Lactobacillus rhamnosus GG (LGG) restores C-section-induced dysbiosis, including an increase in Bifidobacterium and a reduction in Proteobacteria in breastfed but not formula-fed 3-month-old infants.11 Investigation on the effect of probiotic supplementation on NEC using multiple strains of Lactobacillus, Bifidobacterium, and Streptococcus indicated a breastfeeding-dependent decrease in the morbidity and mortality of NEC.15,16 Similar to probiotics, the effect of fecal microbiota transplantation in restoring C-section-induced dysbiosis in newborns may also depend on breastfeeding.123 Although the effect of other possible ingredients in breast milk cannot be excluded, the milk SIgA-mediated enhancement of the colonization of these probiotics (commensals) could be essential, as discussed above.17 Furthermore, it indicates that SIgA supplementation would be beneficial when attempting to restore an imbalanced GM in infants when SIgA from milk is not accessible.