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Order Piccovirales
Published in Paul Pumpens, Peter Pushko, Philippe Le Mercier, Virus-Like Particles, 2022
Paul Pumpens, Peter Pushko, Philippe Le Mercier
After the famous B19V, another member of the Primate erythroparvovirus 1 species, namely an isolate V9, was used to produce the corresponding VLPs in insect cells (Heegaard et al. 2002). Ekman et al. (2007) obtained the insect cells-produced VP2, alone or together with VP1, VLPs of the A6-, LaLi-, and V9-like isolates that nevertheless belong to the same B19V species.
Human Bocavirus
Published in Dongyou Liu, Handbook of Foodborne Diseases, 2018
José Luiz Proença-Módena, Guilherme Paier Milanez, Eurico Arruda
Interestingly, the genus Erythroparvovirus consists of the species of primate erythroparvovirus 1, primate erythroparvovirus 2, primate erythroparvovirus 3, primate erythroparvovirus 4, rodent erythroparvovirus 1, and ungulate erythroparvovirus 1. As the first human-infecting parvovirus identified in 1975, primate erythroparvovirus 1 (generally referred to as B19 virus, parvovirus B19, or erythrovirus B19) is transmitted by respiratory droplets and blood, and causes erythema infectiosum (i.e., fifth disease or slapped cheek syndrome) in children, arthralgias and arthritis in adults, chronic anemia in AIDS patients, aplastic crisis (or reticulocytopenia) in patients with hemolytic syndromes (e.g., sickle cell anemia or hereditary spherocytosis), and hydrops fetalis in fetuses. It is notable that B19 V demonstrates a tropism for bone marrow and a lifelong persistence in heart tissue, whereas HBoV persists in lymphatic tissue and in tissues afflicted with chronic sinusitis [1,2,9].
The clinical use of parvovirus B19 assays: recent advances
Published in Expert Review of Molecular Diagnostics, 2018
The family Parvoviridae includes viruses with a single-stranded DNA genome, encapsidated in a icosahedral protein capsid, about 22–26 nm in diameter. Replication occurs in the nucleus of infected cells and is highly dependent on cellular environment, so that a productive cycle is usually achieved only in actively dividing cells, or in some cases when supported by complementation from helper viruses. The subfamily Parvovirinae includes viruses infecting vertebrate hosts, within it the most recent taxonomical revision distinguishes eight viral genera, and within each genus individual virus species that collect the viral isolates normally recognized in clinical or laboratory settings. In the genus Erythroparvovirus, the species Primate erythroparvovirus 1 includes the human parvovirus B19 (B19V), and a further subdivision is introduced in three distinct B19V genotypes, that differ in their genome sequence by about 10%, while constituting a single serotype and showing similar biological properties [1].
Quantitative real-time PCR for differential diagnostics of parvovirus B19 infection in acute liver failure patients
Published in Expert Review of Molecular Diagnostics, 2019
Arthur Daniel Rocha Alves, Rita De Cassia Nasser Cubel Garcia, Oswaldo Gonçalves Cruz, Marcelo Alves Pinto, Luciane Almeida Amado Leon
Human Parvovirus B19 (B19V) is a member of the Erythroparvovirus genus within the Parvoviridae family, characterized by a marked tropism for erythroid progenitor cells in the bone marrow [1]. The B19V genome is a single-stranded DNA molecule with approximately 5600 nucleotides, which encodes two capsid proteins (VP1 and VP2), and a single nonstructural protein (NS1) essential for viral replication [2].