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Nanoparticle-Stabilized Liposomes as an Effective Bio-Active Drug Molecule Delivery for Acne Treatment
Published in Namrita Lall, Medicinal Plants for Cosmetics, Health and Diseases, 2022
Catherine Wilkinson, Marco N. De Canha, Namrita Lall
The role of microbial activity in acne progression has been a topic of debate in previous studies. Hypercornification of the follicular ducts results in complete blockage of the ducts, thereby creating an anaerobic environment and providing optimal conditions for microbial colonization (Jappe, 2003). Cutibacterium acnes is one of the major acne-causing microbes which form part of the human skin microbiome, generally existing as a commensal bacterium but capable of occasionally becoming pathogenic. C. acnes produces a secretory lipase with the ability to degrade sebum triglycerides into free fatty acids, which act directly by irritating the follicular epithelium, resulting in an inflammatory response. Studies have shown a correlation between an increased bacterial load of C. acnes and the production of sebum (Doshi et al., 1997; Jappe, 2003).
Epidemiology and antibiotic susceptibility in anaerobic bacteraemia: a 15-year retrospective study in South-Eastern Hungary
Published in Infectious Diseases, 2022
Károly Péter Sárvári, Nóra Bernadett Rácz, Katalin Burián
Lassmann et al. and Kim et al. considered Cutibacterium acnes as a contaminant instead of being a true pathogen and our investigation was based on this interpretation [9,21]. The interpretation of Cutibacterium acnes bacteraemia in clinical aspect is a quite hard task to decide whether it is a contamination or a real infection. Generally, Cutibacterium acnes is considered as a contaminant, but as a low virulent bacterium it can be real causative agent. To reduce contamination, the following recommendations should be taken into consideration: (1) alcohol-based disinfectants are more effective than non-alcoholic solutions in skin antispesis, (2) wearing non-sterile gloves, (3) lower contamination rate in venipuncture than sample taking from catheter, (4) organising a professional phlebotomic team, (5) education of medical and nursing staffs, (6) discarding the first few milliliters, (7) taking an adequate volume of blood (8) and taking solitary BC [28].
Clascoterone cream (1%) topical androgen receptor inhibitor for the treatment of acne in patients 12 years and older
Published in Expert Review of Clinical Immunology, 2021
As acne vulgaris has a complex etiology [29], a wide range of therapies have been developed to treat it [30]. The choice of therapy may be based on patient age, gender, anatomic site, ethnicity and severity [31,32]. All therapies are effective for some patients but not all therapies work for all patients. First-line treatment for mild or moderate acne vulgaris includes topical benzoyl peroxide or a topical retinoid, or a combination of topical medications consisting of benzoyl peroxide and erythromycin or clindamycin, a retinoid or both. Due to the possibility of development of Cutibacterium acnes resistance, topical antibiotics must not be used as monotherapy [1]. Oral therapies for acne include antibiotics, retinoids, antiandrogens and combined oral contraceptives, all of which may have distinct drawbacks for some patients [33]. Severe acne may require a combination of oral and topical products [1].
Growth of Cutibacterium acnes is common on osteosynthesis material of the shoulder in patients without signs of infection
Published in Acta Orthopaedica, 2018
Anna Both, Till O Klatte, Andreas Lübke, Henning Büttner, Maximilian J Hartel, Lars G Grossterlinden, Holger Rohde
In recent years, most likely due to improved diagnostic procedures, an increase in Cutibacterium acnes infections has been noted (Achermann et al. 2014, Shifflett et al. 2016). Cutibacterium acnes, formerly Propionibacterium acnes, is a Gram-positive anaerobic rod-shaped bacterium, commensally inhabiting the pilosebaceous unit in humans. Though a part of the normal human skin microbiota, C. acnes is also implicated in biofilm-associated infections and inflammatory processes, such as prosthetic valve endocarditis, infection of breast or eye implants, and acne vulgaris (Aubin et al. 2014, Beylot et al. 2014, van Valen et al. 2016). Of note, C. acnes is increasingly recognized as an important pathogen in bone and joint infections (Achermann et al. 2014). The shoulder is the most commonly affected joint in C. acnes infections. In fact, C. acnes has previously been isolated in one-quarter of revision arthroscopies for shoulder pain or stiffness after a first arthroscopy (Horneff et al. 2015). Even more strikingly, C. acnes has been identified as the most frequently isolated pathogen in prosthetic shoulder joint infections (Piper et al. 2009, Kadler et al. 2015).