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Urinary Tract Infections
Published in Firza Alexander Gronthoud, Practical Clinical Microbiology and Infectious Diseases, 2020
Proteus mirabilis, Pseudomonas aeruginosa, and Enterococcus spp. predominantly cause complicated infections and are more commonly isolated in hospitals and long-term care facilities. Corynebacterium urealyticum is an important nosocomial uropathogen associated with indwelling catheters. Staphylococcus saprophyticus tends to cause infection in young women who are sexually active.
Infections in Solid Organ Transplant Recipients Admitted to the Critical Care Unit
Published in Cheston B. Cunha, Burke A. Cunha, Infectious Diseases and Antimicrobial Stewardship in Critical Care Medicine, 2020
Almudena Burillo, Patricia Muñoz, Emilio Bouza
Notwithstanding, UTI is not a common cause of CCU admission. These infections usually present with a lack of systemic symptoms, with or without accompanying localized urinary symptoms; ureteral obstruction due to anastomosis site stenosis; hydronephrosis, or, less frequently, APN, and sepsis [73]. The most common pathogens include Enterobacteriaceae, enterococci, staphylococci, and Pseudomonas spp. [74]. Other less frequent microorganisms, such as Salmonella spp., Candida spp., and Corynebacterium urealyticum pose specific management problems in this population [75]. It is also important to remember the possibility of infection caused by unusual pathogens such as Mycoplasma hominis, M. tuberculosis, or BK polyomavirus (BK) and JC polyomavirus (JC). Unless another source of fever is readily apparent, any febrile KT patient with an abrupt deterioration in renal function should be treated with empiric antibacterial therapy aimed at gram-negative bacteria, including P. aeruginosa, after first obtaining blood and urine cultures, especially in the first 3 months of transplantation [76,77]. Examination of the iliac fossa is particularly important after KT. Tenderness, erythema, fluctuance, or an increased allograft size may indicate the presence of an infection caused by a microorganism resistant to antimicrobial resistance to drugs commonly used to prevent UTI in these patients such as cotrimoxazole or quinolones; thus, these drugs should not be selected for empirical therapy of severe UTI [78,79].
New Insights of Corynebacterium kroppenstedtii in Granulomatous Lobular Mastitis based on Nanopore Sequencing
Published in Journal of Investigative Surgery, 2022
Xin-Qian Li, Jing-Ping Yuan, Ai-Si Fu, Hong-Li Wu, Ran Liu, Tian-gang Liu, Sheng-Rong Sun, Chuang Chen
In nanopore sequencing method, 39 (78.0%) were positive, which was significantly higher than culture methods (p < 0.001) (Figure 1A). Fourteen genera were detected from 39 patients, and 18 species from 38 patients (Figure 1D). Consistently, the dominant genera and species were Corynebacterium (32/50, 64%) and C. kroppenstedtii (28/50, 56%), respectively. Notably, C. kroppenstedtii coexisted with other pathogens in five cases, including one with fungi (Table S1); other Corynebacterium species were also detected, such as Corynebacterium tuberculostearicum, Corynebacterium urealyticum, and Corynebacterium amycolatum.
Managing recurrent urinary tract infections in kidney transplant patients
Published in Expert Review of Anti-infective Therapy, 2018
Marta Bodro, Laura Linares, Diana Chiang, Asuncion Moreno, Carlos Cervera
Other pathogens that should be considered in recurrent UTI in KTR are Corynebacterium urealyticum, often related with obstructive uropathy, and Microsporidia, especially when fever persists [48,49]. These pathogens can be easily overlooked because detection requires prolonged urine incubation in the case of C. urealyticum and molecular techniques in the case of Microsporidia.