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Angiogenesis and Roles of Adhesion Molecules in Psoriatic Disease
Published in Siba P. Raychaudhuri, Smriti K. Raychaudhuri, Debasis Bagchi, Psoriasis and Psoriatic Arthritis, 2017
Asmita Hazra, Saptarshi Mandal
Chemerin (CMKLR1 ligand) is an attractive candidate that is secreted as an adipokine and is leaked through plasma in the local milieu and is processed into the highly active form by neutrophil elastase and processed to a less active form by mast cell tryptase and chymase.
Chemerin Ratios to HDL-cholesterol and Adiponectin as Biomarkers of Metabolic Syndrome
Published in Endocrine Research, 2020
Julie Shafer-Eggleton, Beverley Adams-Huet, Ishwarlal Jialal
Chemerin, an adipokine produced largely by the liver and adipose tissue, is a chemoattractant for dendritic cells and macrophages.5,6 It also induces insulin resistance, as well as promoting adipogenesis, inflammation, and angiogenesis in adipose tissue.5,6 It appears to mediate its effects via three receptors the predominant one being the G protein-coupled chemokine-receptor1 (CMKLR1).5,6 A study performed in a Korean adult population reported that patients with both the highest chemerin levels and lowest adiponectin levels were at the greatest risk for MetS.7 Additionally, we previously reported that both plasma chemerin and subcutaneous adipose tissue secreted chemerin are increased in patients with MetS without major confounding variables such as diabetes, ASCVD, smoking, and dyslipidemia therapy.8 Accordingly, in this pilot study, we examined the chemerin:HDL-C and chemerin:adiponectin ratios to determine if they are better biomarkers than hsCRP in predicting nascent MetS.
Protective effect of vitamin D supplementation in a rat modal of preeclampsia: a possible implication of chemerin
Published in Hypertension in Pregnancy, 2019
Seham Zakaria Nassar, Noha Mohamed Badae
Many studies reported that high levels of chemerin can induce hypertension through CMKLR1 receptor, and is positively correlated with the degree of atherosclerosis development (12,33). Stejskal et al. reported that chemerin released from periadventitial fat caused arterial vasoconstriction through the CMKLR1 receptor (34). In addition, Wittamer et al. found that blood chemerin level is positively correlated with the onset of coronary artery disease in adult Chinese (35). Moreover, the expression of CMKLR1 in foam cells was also significantly correlated with aortic atherosclerosis (36). Interestingly, hypertension and acute atherosclerotic lesions in the uterine spiral artery are also typical symptoms and pathological changes in patients with preeclampsia, which may explain the role of chemerin in the development of PE (37).
Relationship of circulating chemerin and omentin levels with Th17 and Th9 cell immune responses in patients with asthma
Published in Journal of Asthma, 2018
Qing Zhou, Yu Fu, Liangan Hu, Qian Li, Meng Jin, E. Jiang
Both pro- and anti-inflammatory roles of chemerin and CMKLR1 in immune processes were documented in studies on animal- and cell-based models [7]. A growing body of literature has associated high chemerin levels with inflammation in the synovial fluid of patients with rheumatoid arthritis and osteoarthritis [30], as well as in the serum of patients with chronic pancreatitis [31], chronic obstructive pulmonary disease [32], psoriasis [33] and inflammatory bowel disease (ulcerative colitis and Crohn's disease) [34]. In our study, plasma chemerin levels were elevated in asthmatic patients, but only the severe persistent asthmatics had a statistically significant increase compared to the controls. Thus, chemerin appears to have a role in the systemic inflammatory response. However, Doyle et al. [35] reported that the activation of chemerin receptors decreased allergic airway inflammation in a mouse model of asthma, which was apparent both histologically and by reduced eosinophil counts in bronchoalveolar lavage fluid. The conflicting results on the effects of chemerin may be attributed to varying roles played by chemerin in different phases of inflammation [7].