China
Africa
Explore chapters and articles related to this topic
Suicide-focused interventions (SFIs) and protocols
Published in Lorraine Bell, Helping People Overcome Suicidal Thoughts, Urges and Behaviour, 2021
Shand et al (2013) describe a suicide prevention ACT-based app and study for indigenous Australian youths. Results were reported by Tighe (2017), but although the treatment group had greater reduction in suicidal ideation compared to the control group, this did not reach statistical significance. MYPLAN is a mobile phone application designed to support people at risk of suicide by letting them create a safety plan (Skovgaard Larsen et al 2016). This app allows the user to create an individualised safety plan by filling in templates with strategies, actions and direct links to contact persons. It was developed in 2013 and is freely available in Denmark and Norway. Andreasson et al (2017) describe a protocol they are currently using to evaluate the effectiveness of a safety plan app (MYPLAN) compared to a safety plan on paper on reducing suicidal ideation. It is encouraging that service users have been involved in its development (Buus et al 2019). An RCT by Bush et al (2017) of 118 veterans who had recently expressed suicidal ideation assigned patients to use a virtual hope box (VHB) or to a control group that received printed materials about coping with suicidality, to supplement TAU over a 12-week period. The VHB users reported significantly greater ability to cope with unpleasant emotions and thoughts, though no significant advantage was found on other outcome measures.
The Mediating Role of Coping Self-Efficacy in Hope Box Use and Suicidal Ideation Severity
Published in Archives of Suicide Research, 2019
Lauren M. Denneson, Derek J. Smolenski, Brian W. Bauer, Steven K. Dobscha, Nigel E. Bush
The Virtual Hope Box (VHB: Bush et al., 2017) smartphone application was designed to be a virtual counterpart to the traditional, physical hope box because many times it is impractical for patients to carry their physical hope box with them. The VHB is a mobile application that provides a more convenient way for individuals to privately access the items within their hope box during a crisis, regardless of their location. The application presents different varieties of coping strategies, including distraction, engaging social support, and relaxation tools. In a previously reported randomized controlled trial (Bush et al., 2017), we examined whether participants assigned to use the VHB would report reduced suicidal ideation over time as compared to those assigned to the enhanced treatment as usual (eTAU) group. Findings showed a statistically significant decrease in suicidal ideation severity for both groups; however, there was no discernible difference between the treatment groups in the magnitude of the decrease.
Correlates of Mental Health Smartphone Application Use among Patients with Suicidal Ideation
Published in Journal of Technology in Human Services, 2018
Jason I. Chen, Derek J. Smolenski, Steven K. Dobscha, Nigel E. Bush, Lauren M. Denneson
We defined use of the VHB with two usage measures: (a) the number of times content was accessed and (b) the amount of time spent on each activity. Data on the usage of the app were recorded (with the consent of the participant) using an automatic activity log embedded within the VHB. We analyzed usage metrics data both for total application usage and separately for each of the content areas. As the distributions for these variables were positively skewed, we employed natural log transformation prior to inclusion of these two measures in the models predicting change over time. Given the number of content domains and the nonindependence of each content area, we chose to use omnibus measures of usage in formal analysis as opposed to attempt to isolate correlates of usage specific to any content domain or any domain’s unique association with change in the behavioral outcomes.
Engineered Escherichia coli Nissle 1917 with urate oxidase and an oxygen-recycling system for hyperuricemia treatment
Published in Gut Microbes, 2022
Rui Zhao, Zimai Li, Yuqing Sun, Wei Ge, Mingyu Wang, Huaiwei Liu, Luying Xun, Yongzhen Xia
Several other enzymes may be useful in constructing an engineered bacterium for UA degradation. To overcome oxygen shortage in the gut, the bacterial hemoglobin (VHb) from Vitreoscilla sp. is often used.31 The E. coli catalase KatG efficiently removes H2O2.32,33 Moreover, YgfU from E. coli is a proton-gradient-dependent transporter for UA.34