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Nutritional Diseases
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
Chelsea Kesty, Madeline Hooper, Erin McClure, Emily Chea, Cynthia Bartus
Clinical presentation: Riboflavin deficiency may manifest clinically as the oral-ocular-genital syndrome, which includes cheilitis, glossitis, angular stomatitis, pharyngitis, corneal vascularization, seborrheic dermatitis, and genital dermatitis. Normocytic-normochromic anemia may be present.
Acute Leukemia and Myelodysplastic Syndromes
Published in Harold R. Schumacher, William A. Rock, Sanford A. Stass, Handbook of Hematologic Pathology, 2019
Mark D. Brissette, James D. Cotelingam
The white blood cell count can be elevated, but is frequently normal or low. Blasts are usually present in the peripheral smear. A normocytic, normochromic anemia is commonly present and may be severe. Thrombocytopenia is also usually present and is generally severe. Blast cells in the peripheral blood, associated with anemia and thrombocytopenia, is strongly suggestive of acute leukemia.
Porphyric Red Cells
Published in Ronald L. Nagel, Genetically Abnormal Red Cells, 2019
The disease is characterized by severe erythema, blistering, and scar formation on sun-exposed areas of the body. Facial hypertrichosis is prominent and there is usually excretion of red urine. The patient usually has liver involvement, at least histologically whereas the spleen is not involved. There is usually a mild normochromic anemia.148 The excretion of porphyrins in the urine can be similar to that found in porphyria cutanea tarda with elevation of uro- and heptaporphyrins. In feces, coproporphyrin is elevated, whereas the erythrocytes contain increased amounts of protoporphyrin usually chelated as zinc protoporphyrin. In some cases fluorescent normoblasts have been detected.148
Clinical and biological profile of Sickle Cell Anemia children in a rural area in Central Africa
Published in Hematology, 2023
Gloire Mbayabo, Mamy Ngole, Paul Kabuyi Lumbala, Aimé Lumaka, Valerie Race, Gert Matthijs, Tite Minga Mikobi, Koenraad Devriendt, Chris Van Geet, Prosper Tshilobo Lukusa
Biological data showed normocytic normochromic anemia with high reticulocytes count and signs of hemolysis (Table 1 and Table 2). Direct bilirubin and creatinine levels were significantly different between girls and boys, with higher levels in boys (Table 2). Mean HbF levels were 7.46%±1.86 (range 0-33.1), and were significantly higher in girls (10.73 ± 7.69%) compared to boys (8.64 ± 4.91%) (p = 0.003) (Table 2). We observed an inverse correlation between fetal hemoglobin and the disease severity score (p = 0.005, r −0.239, IC95% −6.139; −1.469) (Figure 3). Moreover, fetal hemoglobin levels tended to decrease with age (Figure 2). Biological factors not included in the severity score that were associated with disease severity include neutrophil count (higher in moderate versus severe disease, with p = 0.028) (Supplementary table 5) and HbF levels (inversely correlated with disease severity) (Table 3, supplementary table 5, Figure 3).
Anti-inflammatory, anti-oxidant and hepatoprotective effects of lactoferrin in rats
Published in Drug and Chemical Toxicology, 2021
Ayman Samir Farid, Mona A. El Shemy, Ebtesam Nafie, Ahmed Medhat Hegazy, Ehab Yahya Abdelhiee
The mean and standard error values of the blood parameters obtained from various groups are mentioned in Table 1. A comparison between the CCl4 group and the control group, showed a significant decrease (p < 0.05) in the RBC count, volume of RBCs, and hemoglobin content. It was also accompanied by normal MCV and MCHC resulting in a state of normocytic normochromic anemia. When LF, LF-protected, and LF-treated groups were compared to the control group, a non-significant change in the hematological parameters was observed. With respect to the LF and LF-protected groups, there was a significant increase (p < 0.05) in the RBC count, the volume of RBCs, and hemoglobin content when compared with the CCl4 group. The LF-treated group showed a non-significant change in the volume of RBCs and hemoglobin content in comparison with the CCL4 group.
Intravascular large B-cell lymphoma in Hispanics: a case series and literature review
Published in Journal of Community Hospital Internal Medicine Perspectives, 2020
Pertinent laboratory findings are summarized in Table 1. Infection work-up was negative for influenza A/B, Cytomegalovirus (CMV), human immunodeficiency virus (HIV), hepatitis A/B/C, blood and urine cultures. Tuberculosis (TB) and fungal studies were not done at the time due to low suspicion. Polymerase chain reaction was positive for Epstein Barr virus (EBV) only in Case 3 at 976 copies/mL (<200 copies/mL). Autoimmune work-up was negative for antinuclear antibody with elevated erythrocyte sedimentation rate and C-reactive protein. For anemia work-up, ferritin was elevated in Case 1 and Case 2 and was not ordered in Case 3. Folate and vitamin B12 were unremarkable. LDH was elevated in all three cases but indirect bilirubin was mildly elevated only in Case 2. Peripheral smear showed normocytic normochromic anemia without blast.