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Nutritional Diseases
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
Chelsea Kesty, Madeline Hooper, Erin McClure, Emily Chea, Cynthia Bartus
Clinical presentation: Riboflavin deficiency may manifest clinically as the oral-ocular-genital syndrome, which includes cheilitis, glossitis, angular stomatitis, pharyngitis, corneal vascularization, seborrheic dermatitis, and genital dermatitis. Normocytic-normochromic anemia may be present.
Multiple Myeloma
Published in Pat Price, Karol Sikora, Treatment of Cancer, 2020
Hematopoiesis is frequently impaired in myeloma. A normochromic, normocytic anemia (occasionally macrocytic) is common, with a hemoglobin below 120 g/L seen in 60% of patients and commoner with renal impairment. Severe anemia, neutropenia, and thrombocytopenia are, however, rare at presentation and commoner with advanced disease.
The Hematologic System and its Disorders
Published in Walter F. Stanaszek, Mary J. Stanaszek, Robert J. Holt, Steven Strauss, Understanding Medical Terms, 2020
Walter F. Stanaszek, Mary J. Stanaszek, Robert J. Holt, Steven Strauss
Acuteposthemorrhagic anemia is caused by the rapid loss of a large amount of blood. Although the RBC count, hemoglobin, and hematocrit may be relatively high initially because of vasoconstriction, they usually drop within a few hours as fluid from the tissue enters the circulation and dilutes the blood. Because the change is rapid, the anemia is normocytic (cells are normal) and normochromic (normal amount of hemoglobin in the erythrocytes, resulting in normal color).
Clinical and biological profile of Sickle Cell Anemia children in a rural area in Central Africa
Published in Hematology, 2023
Gloire Mbayabo, Mamy Ngole, Paul Kabuyi Lumbala, Aimé Lumaka, Valerie Race, Gert Matthijs, Tite Minga Mikobi, Koenraad Devriendt, Chris Van Geet, Prosper Tshilobo Lukusa
Biological data showed normocytic normochromic anemia with high reticulocytes count and signs of hemolysis (Table 1 and Table 2). Direct bilirubin and creatinine levels were significantly different between girls and boys, with higher levels in boys (Table 2). Mean HbF levels were 7.46%±1.86 (range 0-33.1), and were significantly higher in girls (10.73 ± 7.69%) compared to boys (8.64 ± 4.91%) (p = 0.003) (Table 2). We observed an inverse correlation between fetal hemoglobin and the disease severity score (p = 0.005, r −0.239, IC95% −6.139; −1.469) (Figure 3). Moreover, fetal hemoglobin levels tended to decrease with age (Figure 2). Biological factors not included in the severity score that were associated with disease severity include neutrophil count (higher in moderate versus severe disease, with p = 0.028) (Supplementary table 5) and HbF levels (inversely correlated with disease severity) (Table 3, supplementary table 5, Figure 3).
Iron metabolism abnormalities in autoimmune hemolytic anemia and Jianpishengxue keli can ameliorate hemolysis and improve iron metabolism in AIHA mouse models
Published in Annals of Medicine, 2023
Manjun Zhao, Yan Wang, Jin Yang, Yi Wang, Yingying Feng, Lei Chen, Zonghong Shao, Huaquan Wang, Limin Xing
Rat RBCs was purchased from Zhengzhou Bestgene biotech company (Henan, China). Sixty-five mice were selected and randomly divided into normal control group, model group. We established AIHA mouse models using classical rat erythrocyte intraperitoneal immunization [20,21]. After adaptive feeding for one-week, healthy female C57BL/6J mice (age, 6–8 weeks; weight, 20–25 g) were weighed, then blood was collected from the inner canthus. Routine blood parameters were evaluated, and plasma levels of TBIL, DBIL, IBIL, LDH, and hepcidin were measured. Stock suspensions of rat RBCs (1 × 109/mL of normal saline) were prepared, then the experimental group was injected intraperitoneally (i.p.) with 2 × 108 RBCs/200 μL of normal saline, and the controls were injected i.p. with 200 μL of normal saline on the first and third days of each week for 12 weeks. The overall status of the mice was assessed, and they were weighed weekly. Routine blood parameters were evaluated, and plasma levels of TBIL, direct bilirubin (DBIL), IBIL, lactate dehydrogenase (LDH), and hepcidin were measured at 12 weeks. Normocytic normochromic anemia or Hb levels decreased by > 2 g/dL, and increased plasma levels of bilirubin and LDH indicated successful modeling.
Anemia and its predictors among adult non-dialysis chronic kidney disease patients in Southern Ethiopia: a cross-sectional study
Published in Current Medical Research and Opinion, 2022
Aschalew Kidanewold, Berhanu Woldu, Asmare Getie, Bamlaku Enawgaw
In this study, the overall prevalence of anemia in CKD patients was 44.0%. It is considered a severe health complication among CKD patients. The majority of CKD patients developed moderate anemia. Anemia of CKD was more prevalent and severe when the stage of CKD became more advanced. Normocytic normochromic type of anemia was most predominant followed by the microcytic hypochromic type. CKD anemia was strongly associated with CVD, DM and stages of CKD. Therefore, early diagnosis and management of anemia are needed for anemic CKD patients to improve their quality of life. Furthermore, a longitudinal follow-up study with large sample size is recommended to determine the true cause–effect relationship of predictors with anemia of CKD. Additional tests such as serum iron, TIBC, folate and vitamin B12 are needed to assess iron and nutritional deficiencies in CKD patients. The authors also recommended that periodic screening and intervention programs of CKD anemia should be given more emphasis to control the occurrence of anemia and its complications.