China
Africa
Explore chapters and articles related to this topic
Lymphocytes and The Immune Response
Published in Richard C. Niemtzow, Transmembrane Potentials and Characteristics of Immune and Tumor Cell, 2020
Lymphocytes, as well as the other components of the hematopoietic system, are derived from a pluripotential stem cell originating in the fetal liver or adult bone marrow. In response to unknown factors, the stem cell becomes a unipotential precursor cell. The two classes of lymphocytes, T and B cells, are a result of precursor cell differentiation in the microenvironment of the primary lymphoid organs.
Human Liver Stem Cells:
Published in Gianfranco Alpini, Domenico Alvaro, Marco Marzioni, Gene LeSage, Nicholas LaRusso, The Pathophysiology of Biliary Epithelia, 2020
Additionally, CD31 expressing cells (endothelial cell phenotype) also arise in c-kit derived cultures60 raising the possibility that the cells may also have hemangioblast67 (endothelial precursor) potential. This is postulated to be an early progenitor cell in the bone marrow during embryogenesis in several species including mice, with the capability of giving rise either to endothelial lineage or cells of the haematopoietic system.
The Macrophage Inflammatory Protein Family
Published in Richard Horuk, Chemoattractant Ligands and Their Receptors, 2020
Disorders of the hematopoietic system — Breakdown of the hematopoietic regulatory control mechanisms leading to loss of bone marrow homeostasis is an intrinsic factor in the etiology of some diseases. In many cases the exact nature of the breakdown is poorly understood; however, it seems likely that variations in the expression of both normal mediators and or their receptors plays a major role in the pathobiology of disease states. There are some indications that the SCI activity of MIP-1α may play a role in the pathobiology of marrow dysfunctional states such as Diamond Blackfan anemia156 and severe aplastic anemia.157 Complex synergistic effects of chemokines on myelosuppression have been reported134 and it remains to be determined whether alterations in such chemokine interactions are involved in the pathogenesis of hematopoietic disease states.
Retrospective study of risk factors for pericardial effusion after haematopoietic stem cell transplantation in children
Published in Hematology, 2023
Ke Tong, Yan Meng, Luying Zhang, Xiaoying Lei, Xianmin Guan, Li Xiao, Jie Yu, Ying Dou
A total of 452 children with HSCT were enrolled, namely, 307 males (68%) and 145 females (32%). The median age at transplantation was 3.4 (1.8-6.5) years. There were 253 patients (56%) with haematopoietic system diseases (including leukaemia, aplastic anaemia, severe thalassemia, and myelodysplastic syndrome), 180 patients (40%) with primary immunodeficiency diseases, 14 patients (3%) with lymphoid system diseases (including various lymphoid tumors, haemophagocytic syndrome, and lymphoproliferative diseases), and 5 patients (1%) with solid tumors (including neuroblastoma and pinealoblastoma). There were 444 patients (98%) who underwent allogeneic HSCT and 8 patients (2%) who underwent autologous HSCT. There were 216 patients (48%) with matched HLAs and 236 patients (52%) with mismatched HLAs. Regarding the stem cell source, 427 patients (94.4%) received peripheral blood, 3 (0.7%) received bone marrow, 15 (3.3%) received cord blood, 3 (0.7%) received peripheral blood and cord blood, and 4 (0.9%) received bone marrow and cord blood. The characteristics of the study patients are summarized in Table 1.
Serum CCL28 as a biomarker for diagnosis and evaluation of Sjögren’s syndrome
Published in Scandinavian Journal of Rheumatology, 2023
X Yu, F Zhu, X Yu, J Wang, B Wu, C Li
After detection of the expression of CCL28 in the serum of SS patients, the correlations between serum IgA content, the focus score of LSGs, and serum CCL28 level were explored. SS patients were divided into two groups based on the presence or absence of dry mouth, dry eyes, dental caries, arthritis, serum ANA titre ≥ 1:320 or < 1:320, presence or absence of RF, SSB antibodies, and inflammatory macrophage (M2) antibodies, and haematopoietic system involvement or non-involvement. The criteria for haematopoietic system involvement are the presence of leucopenia or anaemia or thrombocytopenia. Leucopenia refers to < 3.5 × 109/L leucocytes in peripheral blood. Anaemia refers to an adult male haemoglobin level of < 120 g/L and adult female haemoglobin of < 110 g/L. Thrombocytopenia refers to a platelet count < 100 × 109/L in peripheral blood. The levels of serum CCL28 in the two groups were compared.
Gene expression profiles and cytokine environments determine the in vitro proliferation and expansion capacities of human hematopoietic stem and progenitor cells
Published in Hematology, 2022
Roberto Dircio-Maldonado, Rosario Castro-Oropeza, Patricia Flores-Guzman, Alberto Cedro-Tanda, Fredy Omar Beltran-Anaya, Alfredo Hidalgo-Miranda, Hector Mayani
Blood cell production (hematopoiesis) is a complex and tightly regulated process that involves different cell types and a variety of molecular regulators [1,2]. The hematopoietic system can be viewed as a hierarchy of different cellular compartments, from self-renewing multipotent hematopoietic stem cells (HSCs) to mature non-dividing circulating blood cells of different lineages. Intermediate compartments include multipotent, oligopotent, bipotent, and monopotent progenitors (HPCs), as well as morphologically recognizable precursor cells [3]. The HSC compartment corresponds to <0.05% of bone marrow cells and consists of different subpopulations of self-renewing cells expressing cell surface markers CD34, CD49f, CD90, CD117 and CD133 [4,5]. HPCs, on the other hand, correspond to 0.1–0.5% of bone marrow cells; they are unable to self-renew but possess high/intermediate proliferation potentials and are capable of forming colonies in semisolid cultures. They express variable levels of CD34, CD38, and CD45RA, and acquire lineage-specific antigens depending on their commitment to particular cell lineages [3].