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Hemolytic Disease of the Fetus and Newborn
Published in Vincenzo Berghella, Maternal-Fetal Evidence Based Guidelines, 2022
Pedro Argoti, Ana M. Angarita, Giancarlo Mari
Donor blood requirements (as per the guidelines of the American Association of Blood Banks) [13]:Rh D negative donor bloodCMV antibody negativeIrradiation (25 Gy of gamma radiation to the central part of the donor bag)Negative hemoglobin S screeningLeukoreductionDonor units should be fresh (<7 days old)Units should be washed and packed to a final hematocrit of 75–85%Some centers undergo extended cross-matching e.g. S, Duffy, and Kidd antigens
Human organs, tissues and biological materials
Published in Gary Chan Kok Yew, Health Law and Medical Ethics in Singapore, 2020
The Health Sciences Authority (HSA) administers blood donation at various locations in Singapore. A person who knows that he has HIV is prohibited from donating blood to a blood bank in Singapore; and he is deemed to know that he has HIV Infection if a serological test or other test for the purpose of ascertaining the presence of HIV Infection carried out on him has given a positive result and the result has been communicated to him.68 Non-compliance will attract criminal penalties. At common law, a person who has contracted HIV from donated blood may pursue a negligence action against the blood banks if the recipient is able to prove that the inadequacies of the bank’s donor screening procedures had materially contributed to the contraction of HIV.69
Quality Control in Bone Marrow Processing
Published in Adrian P. Gee, BONE MARROW PROCESSING and PURGING, 2020
Ideally, all aspects of ex vivo marrow manipulation should be performed within a single laboratory with the ability to process, manipulate, cryopreserve, and store the marrow until the time of the transplant. In reality, these tasks are often performed at separate locations within an institution, e.g., the blood bank performs the nucleated cell separation, a research laboratory carries out T cell depletion or tumor purging, and the transplant laboratory cryopreserves and stores the processed marrow. While this is technically feasible, for efficient operation it is vital to ensure that there is excellent communication between the individual laboratories, and that the component parts effectively function as a single entity. Where available space and budget permit, a purpose-designed laboratory is the preferable alternative.
Platelets for advanced drug delivery in cancer
Published in Expert Opinion on Drug Delivery, 2023
Daniel Cacic, Tor Hervig, Håkon Reikvam
The interplay between platelets and cancer cells is essential in cancer biology. Thus, using platelets or other platelet-engineered hybrid technologies as drug delivery systems is an increasingly interesting strategy to improve drug efficacy and reduce harmful adverse events in cancer. Preclinical data are promising, and this technology may provide therapeutic benefits through selective targeting of cancer cells, improved cancer cell drug uptake, and slowed drug elimination. Platelet concentrates are also readily available from blood banks, relatively cheap to manufacture, and safe for transfusion. Thus, platelets have many advantages as drug delivery systems over synthetic drug carriers. However, unlike synthetic formulations, there is no clinical data on platelet- or platelet-inspired drug delivery systems in humans. Thus, the clinical relevance of this technology remains to be determined.
Thalassemia in the Philippines
Published in Hemoglobin, 2022
Ernesto d’J. Yuson, Maria Liza T. Naranjo
Until the mid-1990s, commercial blood banks were mainly utilized to provide blood to needy recipients. When the Republic Act (RA) #7719 National Blood Services Act of 1994 was mandated into law in 1997, the impetus for strictly non remunerated blood from voluntary donors was gradually established and accepted. The Philippine Blood Center (PBC) is a national blood source for the country’s hospitals. The Philippine Red Cross, as an international and private entity, emerged as an additional source of blood. The initial goal of the PBC was to target 1.0% of the total population to become voluntary blood donors, which was achieved during the second decade of the 21st century (2014). A concentrated effort to assert the importance of voluntary blood donation is gaining momentum, especially in communities that still depend highly on blood donor replacement strategies.
T cell recognition of novel shared breast cancer antigens is frequently observed in peripheral blood of breast cancer patients
Published in OncoImmunology, 2019
Nadia Viborg, Sofie Ramskov, Rikke Sick Andersen, Theo Sturm, Tim Fugmann, Amalie Kai Bentzen, Vibeke Mindahl Rafa, Per thor Straten, Inge Marie Svane, Özcan Met, Sine Reker Hadrup
Breast cancer patient samples were kindly provided by the Department of Oncology and the Center for Cancer Immune Therapy, Herlev Hospital, Denmark, with approval by the regional ethics committee for the Capital Region of Denmark. Breast cancer patient samples came from two different cohorts, as listed in Supplementary Table S1. All patient blood samples in cohort 1 were drawn at the time of primary diagnosis, before any treatment was initiated. Patients in cohort 2 were untreated, or treated with one or more standard therapies (chemo-, radiation and endocrine), but did not receive immunotherapy prior to blood sampling. Healthy donor samples were collected by approval of the local Scientific Ethics Committee, with donor written informed consent obtained according to the Declaration of Helsinki. Healthy donor blood samples were obtained from the blood bank at Rigshospitalet, Copenhagen, Denmark. All samples were obtained anonymously.