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Benign Disorders of Leukocytes
Published in Harold R. Schumacher, William A. Rock, Sanford A. Stass, Handbook of Hematologic Pathology, 2019
Gene L. Gulati, Zoran Gatalica, Bong H. Hyun
Basopenia exists when the absolute basophil count falls below the lower limit of normal, usually below 0.01 × 109/L. Basophils, like eosinophils, show diurnal variation; their level is lowest in the morning and highest at night. Acute stress, acute infection, hyperthyroidism, and sustained treatment with adrenal glucocorticoids are some of the conditions known to be associated with basopenia.
Pharmacokinetic-Pharmacodynamic Correlations of Corticosteroids
Published in Hartmut Derendorf, Günther Hochhaus, Handbook of Pharmacokinetic/Pharmacodynamic Correlation, 2019
Helmut Möllmann, Stefan Baibach, Günther Hochhaus, Jürgen Barth, Hartmut Derendorf
Based on the same principle, Wald et al.88 presented a second-generation model to characterize basophil cell movement. It is assumed that corticosteroid-induced basopenia is due to inhibition of basophil redistribution from peripheral compartments. Also, the total number of basophils, as well as their extravascular portion, was assumed to remain constant. Therefore, an apparent zero-order rate constant (kin∘) was used to define the recirculation from extravascular space, whereas the movement to extravascular sites was described by first-order kinetics (kout). AB and AE express the number of basophils in blood and in extravascular space, and I(t) is a fractional inhibition function for the administered corticosteroid, here MP.
Artificial intelligence for diagnosis of mild–moderate COVID-19 using haematological markers
Published in Annals of Medicine, 2023
Krishnaraj Chadaga, Srikanth Prabhu, Vivekananda Bhat, Niranjana Sampathila, Shashikiran Umakanth, Rajagopala Chadaga
Patients with COVID-19 had relatively decreased eosinophil levels. Eosinopenia in COVID-19 patients has already been documented in numerous researches [55,56]. HbA1c was comparatively higher in COVID-19 patients in this study. HbA1c has already been used as a prognostic marker in several COVID-19 studies [57,58]. Liver enzymes such as ALP, ALT, AST and T. bilirubin were comparatively lower in COVID-19 patients. Many studies have reported decreased liver enzymes among coronavirus patients [59,60]. According to our study, TWBC levels decreased in COVID-19 patients. In numerous researches, leukopenia was seen in COVID-19 patients [61,62]. Albumin levels were higher for COVID-19 patients in our study. According to other studies, higher albumin count was observed in mild–moderate COVID-19 patients [63,64]. Monocyte count tends to increase after contracting COVID-19 [65,66]. Our research agrees with the existing literature. Basophil count was lower in COVID-19 patients compared to ILI non-COVID-19 patients in our study. There are similar studies that report basopenia in COVID-19 patients [67,68].
Pediatric chronic spontaneous urticaria: a brief clinician’s guide
Published in Expert Review of Clinical Immunology, 2022
Martina Votto, Giovanna Achilli, Maria De Filippo, Amelia Licari, Alessia Marseglia, Alice Moiraghi, Antonio Di Sabatino, Gian Luigi Marseglia
Moreover, it was found that concomitant inducible urticaria, severe disease, elevated inflammatory markers, and angioedema point to a long duration of CSU and poor response to conventional antihistamine therapy in adults [35]. Kolkhir et al. have shown that eosinophils are reduced in the blood of 1 in 10 adults with CSU, specifically those with type II autoimmunity mechanisms [11]. Furthermore, 80% of CSU patients with undetectable blood eosinophils also had undetectable peripheral basophils [11]. Basopenia has been linked to severe, antihistamine-resistant, and autoimmune CSU [36]. In adults, eosinopenia was also associated with high disease activity, positive autologous serum skin test (ASST), and positive basophil histamine release assay (BHRA) [11]. Finally, in CSU related to type II autoimmunity mechanisms, eosinopenia was also associated with low total IgE levels and high IgG anti-TPO levels [37]. Kolkhir et al. hypothesized that eosinopenia in CSU is a consequence of the recruitment of eosinophils to the skin and their immunologic destruction in the blood [11]. Moreover, Marques et al. found a correlation between the severity of CSU and the extent of eosinophilic infiltration in skin lesions [38].
The effect of omalizumab on hematological and inflammatory parameters in patients with chronic spontaneous urticaria
Published in Cutaneous and Ocular Toxicology, 2019
Ersoy Acer, Hilal Kaya Erdogan, Nihan Yüksel Çanakçı, Zeynep Nurhan Saracoglu
Lorenzo et al. reported that eosinophil count was significantly higher in patients with acute urticaria and symptomatic CU than control group26. However, we found an increase in eosinophil counts with omalizumab treatment in patients with CSU. Eosinophil counts may increase reactively with omalizumab treatment. Generally, during active disease period, basopenia is seen in patients with CSU due to basophil migration into skin. Basopenia reverses with treatment or regression of urticarial lesions3,27. Similarly, in our study there was an increase in basophil counts with omalizumab treatment but this increase was not statistically significant.