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Urology
Published in Janesh K Gupta, Core Clinical Cases in Surgery and Surgical Specialties, 2014
Glomerular causes: Age <50 years IgA nephropathyThin basement membrane diseaseAlport’s disease (hereditary nephritis)Mild focal glomerulonephritis (GN)Age > 50 years IgA nephropathyAlport’s disease (hereditary nephritis)Mild focal GN
Pseudolinear C4d deposits in a hereditary glomerulopathy caused by a rare NC1 collagen-4-alpha-5 missense mutation: a “new disease entity”?
Published in Ultrastructural Pathology, 2019
Sanjeet Roy, Aasma Nalwa, Jared Keith, Karen Weck, Harsharan Singh, Volker Nickeleit
Genetic testing to establish/confirm a diagnosis of hereditary nephropathy is most useful in patients with an established risk profile.23 The sole detection of a so-called mosaic IF staining pattern for Col4A3/5 without other characteristic findings, such as seen in some cases presenting with “thin-basement membrane disease”, will likely not flag patients in whom genetic testing generates diagnostic help. In our patient EM studies revealed a distinct “risk profile” with GBM splitting typical for a hereditary nephropathy; a firm diagnosis could subsequently be established based on genetic testing.
Contribution of Electron Microscopy to the Clinicopathologic Diagnosis in Childhood Glomerular Renal Diseases
Published in Fetal and Pediatric Pathology, 2019
Secil Arslansoyu Camlar, Mehtat Ünlü, Alper Soylu, Duygu Karaca, Sulen Sarioglu, Salih Kavukcu
EM was essential in establishing the diagnosis of hereditary nephropathies like Alport’s disease and thin-basement membrane disease (TBMD) [8, 11]. In Alport’s disease, lamellation of the lamina densa and thickening of the GBM can be demonstrated only by EM [12]. GBM thickness is greater than 300 nm after 5 years old, less than 200 nm is used to define TBMD [17]. EM allows measurement of glomerular basal membrane thickness that differs in TBMD and Alport’s disease.
Deep learning for the classification of medical kidney disease: a pilot study for electron microscopy
Published in Ultrastructural Pathology, 2021
More recently, Ginley et al. developed a digital pipeline to classify renal biopsies from patients with diabetic nephrosclerosis (DN).16 However, this model did not include many other medical nephropathies, such as amyloidosis, fibrillary glomerulonephritis, membranous nephropathy (MN), thin basement membrane disease (TBMD), postinfectious glomerulonephritis (PIGN), and membranoproliferative glomerulonephritis (MPGN).