China
Africa
Explore chapters and articles related to this topic
Antenatal Care—Nutrition and Lifestyle to Improve Conception and Pregnancy Outcomes
Published in James M. Rippe, Lifestyle Medicine, 2019
Obesity impacts fertility beyond ovulation. Obese women who receive donor eggs from normal-weight women are 23% less likely to have successful implantation and 19% less likely to have a live birth.8 But even ovulatory obese women are less likely to conceive, their oocyte and embryo quality are reduced, and they have impaired endometrial receptivity,8 likely secondary to oxidative stress.9 It appears that excessive reactive oxygen species production overpowers the body’s natural antioxidant defense system, creating an environment unsuitable for normal female physiologic reactions that are requisite for successful reproduction.9
The causes of male obesity and associated health problems
Published in Alan White, Maggie Pettifer, Hazardous Waist, 2018
Obesity has been documented for the last 25,000 years (Bray et al., 1997). Prehistoric fertility symbols accurately portray obese women – ironic as we now know that obesity reduces fertility in women. Hippocrates recognised that corpulence led to premature death. But obesity has been a rare phenomenon up until the last 30 years, and so it was not a topic for discussion, study or treatment among early physicians. Gradually, as numbers of cases increased, it became worthy of study, and patterns began to emerge, and it became apparent that obesity affected different people in different ways, men in a different way to women.
A prospective study of C-reactive protein in patients with obesity during IVF
Published in Human Fertility, 2021
Einat Haikin Herzberger, Netanella Miller, Yehudith Ghetler, Rina Tamir Yaniv, Eran Neumark, Adrian Shulman, Amir Wiser
Studies examining the connection between obesity and infertility have found that it has a negative effect on assisted reproductive technology (ART) outcomes. Patients with higher BMI have lower clinical pregnancy rates, yield fewer oocytes per treatment cycle and have higher rates of spontaneous abortion (Maheshwari, Stofberg, & Bhattacharya, 2007; Rittenberg et al., 2011). The effects of obesity on fertility include anovulation, subfertility, higher miscarriage rates, increased adverse pregnancy outcomes and poor endometrial function (Jungheim, Travieso, Carson, & Moley, 2012). We hypothesized that these negative effects might be mediated by elevated CRP levels as part of an increased inflammatory state in overweight women. This pilot study investigated the physiology of CRP during the IVF cycle in women with and without obesity and evaluated the effect of CRP on IVF parameters.
The impact of surgical treatment of obesity on the female fertility
Published in Gynecological Endocrinology, 2019
Radoslaw Slopien, Nikodem Horst, Jesse D. Jaremek, Demelza Chinniah, Robert Spaczynski
It has been shown that the non-surgical treatment of obesity improves fertility [19]. Data on the impact of bariatric surgery on fertility are inconsistent. In a study of 24 women with polycystic ovary syndrome (PCOS), Eid et al. [20] described spontaneous return of ovulation in five women after surgical weight loss. In this study, all women had secondary amenorrhea before the treatment, and all had normal cycles return 3 months after surgery. Deitel et al. [21] described spontaneous pregnancies in 9 out of 30 women, after a weight reduction of 45 kg on average. Bilenka et al. [22] described spontaneous pregnancies in 5 out of 6 women, after a weight reduction of 36 kg on average. Martin et al. [23] have shown a beneficial effect of weight loss on the frequency of conception. Additionally, Marceau et al. [24] described spontaneous pregnancies in 15 women after bariatric surgery. However, the mechanism of increased fertility following significant weight reduction after bariatric surgery is unknown.
Low dose of liraglutide combined with metformin leads to a significant weight loss in Chinese Han women with polycystic ovary syndrome: a retrospective study
Published in Gynecological Endocrinology, 2023
Xuefeng Long, Hengwei Liu, Wenqian Xiong, Wenjin Li, Haitang He, Tian Fu, Xiaoou Li, Chunyan Chen, Ling Zhang, Yi Liu
The majority of women with PCOS are overweight or obese. It is reported that obesity affect fertility by many processes, such as mitochondrial dynamics derangements, disrupted meiosis, impairment of ovarian follicles development [5]. Moreover, obesity may reduce the utilization of glucose by peripheral tissues and aggravating insulin resistance [9]. The excess insulin promotes androgen production in ovarian theca cells as a response to luteinizing hormone stimulation, and result in follicular arrest and anovulation [10]. Otherwise, it is closely related to nonalcoholic fatty liver disease, atherosclerosis, cardiovascular metabolic risks, and other diseases. Consequently, losing weight and ameliorating insulin resistance are essential in the treatment of PCOS.