China
Africa
Explore chapters and articles related to this topic
Satellite cells and exercise
Published in Adam P. Sharples, James P. Morton, Henning Wackerhage, Molecular Exercise Physiology, 2022
Neil R.W. Martin, Adam P. Sharples
Insulin-like growth factor I or IGF-I is an important mediator of tissue growth. IGF-I secreted by the liver in response to growth hormone acts in an endocrine fashion and drives post-natal growth and development of many organs, including the brain, spleen, kidney and bone (103). Skeletal muscle is also a source of IGF-I which can act in an autocrine/paracrine manner to induce muscle growth at the local level (104). In fact, in skeletal muscle, the IGF-I gene can be alternatively spliced during transcription to give rise (in humans) to three different IGF-I isoforms or splice variants: IGF-IEa (which is the same as the liver IGF-I), IGF-IEb and IGF-IEc (105). IGF-IEc has been termed mechano-growth factor (MGF) due to the fact that it is not detectable in resting muscle but is rapidly expressed at the mRNA level following mechanical stretch of rabbit muscle and eccentric exercise in humans (105).
Treatment of Chronic Fatigue Syndrome
Published in Jay A. Goldstein, Chronic Fatigue Syndromes, 2020
My efforts to alter neurotransmitter levels have not been very successful. My strategies to increase (or decrease) serotonin, glutamate, aspartate, somatostatin, CRH, substance P, opioids, norepinephrine, dopamine, and vasopressin have not worked. Various agents to increase neuronal membrane fluidity have not helped, either. Insulin-like growth factor 1 (IGF-1), another name for Somatomedin-C, is low in FM, and is being used in clinical trials. It may be helpful in CFS/FM treatment.
Personalized Nutrition in Children with Crohn Disease
Published in Nilanjana Maulik, Personalized Nutrition as Medical Therapy for High-Risk Diseases, 2020
Diagnostic baseline nutritional testing to screen for micronutrient deficiency should include iron studies and ferritin, vitamin D, vitamin B12 and folate. Assessment of zinc, vitamins A, vitamin E, vitamin C, selenium and magnesium also may be indicated. Micronutrient deficiencies should be corrected with follow-up measurement to confirm response. Measurement of insulin-like growth factor 1 (IGF-1) may be helpful if there is significant linear growth impairment at diagnosis.
Non-islet cell tumor-induced hypoglycemia in the setting of metastatic intracranial hemangiopericytoma: case report and review of the literature
Published in British Journal of Neurosurgery, 2023
Leslie A. Nussbaum, Rebecca M. Walton, Eric S. Nussbaum
Proposed mechanisms of hypoglycemia caused by metastatic hemangiopericytoma include increased glucose utilization by the tumor, suppression of hepatic glucose production, and abnormal secretion of hormones involved in glucose homeostasis.5,13 Our literature review demonstrated low levels of insulin in 6/8 cases (75%), insulin-like growth factor 1 (IGF-1) in 8/8 cases (100%), and growth hormone (GH) in 4/4 cases; compared to normal ranges.8,10 Levels of insulin, IGF-1, C-peptide, and GH are reported to decrease when IGF-2 levels are elevated.16–19 However, increased levels of IGF-2 only occurred in 3/7 cases in our literature review. A high ratio of IGF-2:IGF-1 (>10) might suggest increased levels of IGF-2 precursor secretion.13 Indeed, the IGF-2:IGF-1 ratio ranged from 14 to 296 reported in all 8 cases of our literature review. With early diagnosis, a combined approach of surgical resection, radiation therapy, chemotherapy, and corticosteroid treatment can be used successfully to control hypoglycemic episodes.10,13,14
Effect of leukocyte-platelet fibrin-rich wound reconstruction followed by full-thickness skin grafting in the treatment of diabetic foot Wagner grade 4 ulcer gangrene (toe area)
Published in Platelets, 2023
Yuqi Wang, Yanyan Wang, Xiaotao Wang, Yi Zhao, Siyuan Ruan, Hong Cao
In summary, L-PRF has advantages over other dressings or techniques. The first advantage is the rich content of substances. Monocytes/macrophages and platelets with larger cell structures can help restore a stable wound microenvironment, and they have a certain anti-infection effect [36]. Various growth factors consisting of smaller proteins, including vascular endothelial growth factor, PDGF, TGF-β, epidermal growth factor, Insulin-like growth factor 1 (IGF-1), Hepatocyte growth factor (HGF), IL-1, IL-4, IL-6, and IL-10, etc., supplement the necessary promoting substances for local tissue repair [37]. It is also not negligible that L-PRF can continuously release growth factors for a long time; most growth factors can be released for up to 7 days [38], while others can be released for up to 15 days or even longer [39]. The components of L-PRF and the three-dimensional network structure help prevent the rapid protein breakdown of growth factors, thereby prolonging the secretion time [40]. The long-lasting effect is extremely important for recovery after skin grafting, and the release time of most factors covers the critical period of skin survival (i.e., the early stage when the transplanted skin is most prone to necrosis). This allows the early treatment of L-PRF to not only promote reconstruction of the wound bed but also greatly improve the survival rate of the skin.
Effects of anodyne treatment on local blood flow and cutaneous sensation of the foot in a patient with peripheral neuropathy secondary to acromegaly
Published in Physiotherapy Theory and Practice, 2021
Sean C. Newton, Shelly Marshall
Acromegaly is a hormonal disorder that results most often from a pituitary tumor (adenoma) producing an excessive amount of growth hormone (GH) (Chanson and Salenave, 2008). Characteristically there is higher than normal limits of serum Insulin-like growth factor–I (IGF-I) an intermediate molecule in action of GH (Brabant, 2003; Chanson, 2016; Imrie et al., 2012). One complication of acromegaly is the development of sensorimotor polyneuropathy (Lewis, 1972), which affects neural sensation and/or blood flow in both the hands (Tagliafico et al., 2008) and feet (Jamal et al., 1987). Numbness, tingling or pain, with impaired sensation including kinesthesia and proprioception can occur with this polyneuropathy (Kopsky and Keppel Hesselink, 2013). This, in turn, may lead to increased risk of stumbling and falls when the lower extremities are involved. In the United States, there are approximately 3,000 new cases of acromegaly per year with a prevalence of about 25,000 (Broder et al., 2016). The mortality and morbidity associated with acromegaly can be attributed largely to the action of GH and IGF-I on the cardiovascular system (Clayton, 2003; Paisley et al., 2009).