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Data and Picture Interpretation Stations Cases 1–42
Published in Joseph Manjaly, Peter Kullar, Alison Carter, Richard Fox, ENT OSCEs: A Guide to Passing the DO-HNS and MRCS (ENT) OSCE, 2019
Joseph Manjaly, Peter Kullar, Alison Carter, Richard Fox
What is the diagnosis? Hashimoto thyroiditis
Test Paper 6
Published in Teck Yew Chin, Susan Cheng Shelmerdine, Akash Ganguly, Chinedum Anosike, Get Through, 2017
Teck Yew Chin, Susan Cheng Shelmerdine, Akash Ganguly, Chinedum Anosike
Hashimoto thyroiditis, also known as chronic autoimmune lymphocytic thyroiditis, is a disease with a typical clinical presentation of painless diffuse enlargement of the thyroid gland accompanied by hypothyroidism and thyroid autoantibodies. The sonographic appearance of Hashimoto thyroiditis is well recognised. The gland is often diffusely enlarged, and the parenchyma is coarsened, hypoechoic and often hypervascular. A micronodular pattern on ultrasound is highly diagnostic of Hashimoto thyroiditis with a positive predictive value of 95%. Discrete nodules may, however, also occur within diffusely altered parenchyma or within sonographically normal parenchyma. The nodular form of Hashimoto thyroiditis has not received nearly as much analysis as the diffuse form, and the reported findings have been variable.
Thoracal arachnoiditis ossificans associated with multifocal motor neuropathy: a case report
Published in British Journal of Neurosurgery, 2023
Vladimir Baščarević, Dragoslav Sokić, Aleksandar J. Ristić
Twenty-seven years prior she had a combat-related injury after rocket-propelled grenade and hand grenade explosions. She had suffered blast concussion but had made a full neurological recovery but had several pieces of retained shrapnel in her body. Three years after that incident she sustained another concussion, back contusion and fracture of two thoracic vertebras (T4 and 5) in a car accident which was treated conservatively. In the following years, periodic sensations appeared mainly during sleep time (“severe pressure around chests”). Hashimoto thyroiditis was diagnosed ten years ago, but thyroid hormone levels were normal on several occasions. At the time of the presentation to our institution, she was able to walk with a cane without aid or rest for 100m limited by progressive lower limb weakness and stiffness. She also reported muscle wasting and weakness in both hands, predominantly the right one with the formation of a claw hand during the last two years.
Dioscin alleviates hashimoto’s thyroiditis by regulating the SUMOylation of IRF4 to promote CD4+CD25+Foxp3+ treg cell differentiation
Published in Autoimmunity, 2021
Cao Yongjun, Qiao Nan, Sun Yumeng, Jin Xiaowen, Wen Weibo
Sixteen HT patients (3 males, 13 females) without central nervous system involvement (aged 22–62 years, mean age of 41.56 years) and twenty-four age- and gender-matched healthy controls (4 males, 20 females, and mean age of 42.54 years) were enrolled in the study. All patients fulfilled the criteria for the diagnosis of Hashimoto thyroiditis. All patients took levothyroxine sodium (Merck Serono GmbH) orally at a dose of 125 μg/d. On this basis, dioscin was taken orally at a dose of 10 g/time, 2 times a day, for a total of 3 months. The level of alanine amiotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transpeptadase (GGT), cholesterol (CHOL), high-density lipoprotein (HDL), low-density lipoprotein (HDL), triglyceride (TG), free triiodothyronine (FT3), free thyroxine (FT4), hyroid stimulating hormone (TSH), anti-thyroglobulin antibodies (TgAb), anti-thyroglobulin antibody (TPO-Ab), and blood routine examination, creatinine (Cr), uric acid (UA) of typical patients with HT were detected before and after treatment (Data shown in Supplementary Table 1).
Evaluation of relationship between HbA1c levels and ovarian reserve in patients with type 1 diabetes mellitus
Published in Gynecological Endocrinology, 2020
Pınar Kadiroğulları, Esra Demir, Pinar Yalcin Bahat, Huseyin Kıyak, Kerem Doga Seckin
So far, only a few studies investigated the correlation between autoimmune diseases and decreasing ovarian reserves. The systemic lupus erythematosus (SLE) is an autoimmune disease that may adversely affect fertility. SLE patients of reproductive age have lower ovarian reserve parameters than the healthy controls, including AMH [9,20]. Clowse et al. also investigated the correlation between the ovarian reserve and Wegener's granulomatosis (WG). They found lower AMH and higher FSH levels and higher premature menopause rate in these patients [21]. Brouwer et al. [22] investigated the ovarian reserve of patients with rheumatoid arthritis (RA) and found no difference in ovarian reserve parameters compared to the healthy controls. Tuten et al. showed that there was no disruption in ovarian reserve parameters in patients with Hashimoto thyroiditis. Interestingly, their results revealed a significant increase in serum AMH levels of patients with Hashimoto thyroiditis compared to that of the controls [13].