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Twin Studies of Human Obesity
Published in Claude Bouchard, The Genetics of Obesity, 2020
Joanne M. Meyer, Albert J. Stunkard
Studies of obesity in twin children are relatively few in number. They are, however, of great importance in understanding the etiology of obesity. Indeed, early-onset obesity is not only a good predictor of obesity in adult life;5 it also appears to have strong genetic determinants.6 Consequently, understanding the genetics of obesity in children may be an important step in understanding the genetics of obesity in adults.
Obesity
Published in Andrew Stevens, James Raftery, Jonathan Mant, Sue Simpson, Health Care Needs Assessment, 2018
John Garrow, Carolyn Summerbell
The second argument is that obesity is determined by our genes, and therefore untreatable. Certainly there have been recent advances in our understanding of the genetics of obesity, but it is obvious that the rapid increase in prevalence in the past two decades does not reflect a change in the gene pool of the population, since genetic change can only occur between successive generations. A large part of the cause of the global epidemic must therefore be environmental (the ‘Obesogenic Environment’), and hence (in principle) treatable.
The relationship between anemia and obesity
Published in Expert Review of Hematology, 2022
Ramadan A. Saad, Haitham MohammedHabib Qutob
It has been reported that the main causes of obesity are environmental and genetic factors. Genetic and environmental factors may be complementary to each other; for example, if a person was genetically predisposed to obesity and exposed to obesity-related environmental factors such as lack of exercise and a fast HFD, obesity developed at a higher rate than in individuals with only genetic predisposition or environmental exposure [13]. A study of monozygotic young adult male twins who were overfed by 1000 kcal/d over a 100-day period demonstrated the importance of genetics in the development of obesity [14]. Body weight, percentage of fat, fat mass, and estimated subcutaneous fat all had similar responses within couples. A study of 540 adult adoptees provided further strong evidence of the role of genetics in obesity [15]. Table 1
Dopaminergic and other genes related to reward induced overeating, Bulimia, Anorexia Nervosa, and Binge eating
Published in Expert Review of Precision Medicine and Drug Development, 2022
Kenneth Blum, Panayotis K. Thanos, Gene -Jack Wang, Abdalla Bowirrat, Luis Llanos Gomez, David Baron, Rehan Jalali, Marjorie C Gondré-Lewis, Mark S Gold
Understanding the role of genetics in obesity and eating disorders provides the impetus for a brief explanation of the role of neurotransmitter genetics in these conditions. After many years of successful bariatric (weight-loss) surgeries directed at obesity, clinicians are indicating that some patients (≤ 20%) are substituting overeating with other compulsive disorders like alcoholism, exercising, and gambling [128]. Evidence from psychiatric genetic animal and human studies links compulsive overeating and other compulsive disorders to explain the phenomenon of addiction transfer [129]. Moreover, we hypothesize here that RDS is the root cause of addiction transfer common after bariatric surgery.