De Quervain’s thyroiditis – Knowledge and References

De Quervain's thyroiditis

De Quervain's thyroiditis is a subacute inflammation of the thyroid gland that is often associated with mild hyperthyroidism. It is a transient thyroid state that is most likely caused by a viral infection. This condition is also known as sub-acute viral thyroiditis and is characterized by fever, neck pain, and a tender, enlarged thyroid gland.From: Browse's Introduction to the Symptoms & Signs of Surgical Disease [2019], 500 Single Best Answers in Medicine [2019], Understanding Diabetes and Endocrinology [2019]

The neck

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Published in Kevin G Burnand, John Black, Steven A Corbett, William EG Thomas, Norman L Browse, Browse’s Introduction to the Symptoms & Signs of Surgical Disease, 2014

Kevin G Burnand, John Black, Steven A Corbett, William EG Thomas, Norman L Browse

De Quervain’s thyroiditis occurs in adults. The main complaint is of the sudden appearance of a painful swelling in the neck. The patient feels ill and may notice that they are anxious, sweaty and hungry and have palpitations.

Thyrotoxicosis secondary to thyroiditis following SARS-CoV-2 infection

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Published in Journal of Endocrinology, Metabolism and Diabetes of South Africa, 2021

Ankia Coetzee, Raisa Bhikoo, Bianca Berndorfler, Wilhelmina Conradie, Jantjie J Taljaard, Marli Conradie-Smit

De Quervain’s thyroiditis or subacute granulomatous thyroiditis is a rare inflammatory condition triggered by a viral infection that occurred 2–6 weeks earlier.1,2 Many viruses have been implicated in the development of thyroiditis, but prior to the current pandemic coronavirus infection has never been associated with clinical subacute thyroiditis.3 Single-cell RNA profiling of the angiotensin converting enzyme 2 receptor (SARS-CoV-2 receptor), has proposed multiple tissue cells as the potential targets of SARS-CoV-2.4 Subsequent analysis across 36 tissues revealed a rank list of candidate cells potentially vulnerable to SARS-CoV-2. The top targets are lung cells and macrophages, cardiomyocytes, adrenal gland stromal cells and lastly stromal cells in testis, ovary and thyroid.5 Thyroiditis following COVID-19 may be under-recognized and the complications overlooked if thyrotoxicosis is not considered.

De Quervain's thyroiditis

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The neck

Thyrotoxicosis secondary to thyroiditis following SARS-CoV-2 infection