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Order Sepolyvirales
Published in Paul Pumpens, Peter Pushko, Philippe Le Mercier, Virus-Like Particles, 2022
Paul Pumpens, Peter Pushko, Philippe Le Mercier
The VP1 VLPs of Trichodysplasia spinulosa-associated polyomavirus (TSPyV) of the Human polyomavirus 8 species were produced in insect cells (Chen T et al. 2011; Kumar et al. 2012; Nicol et al. 2013, Nicol et al. 2014). As mentioned earlier, Norkiene et al. (2015) produced the TSPyV VLPs in S. cerevisiae. Moreover, Gedvilaite et al. (2015) exploited the TSPyV VP1 protein as a carrier for construction of the chimeric VLPs harboring selected B and T cell-specific epitopes and evaluated the novel model in comparison to the previously described yeast-produced HaPyV VP1 VLPs. Thus, the chimeric TSPyV VLPs were engineered, which exposed on the surface the model HBV preS1 epitope DPAFR or a universal T cell-specific epitope AKFVAAWTLKAAA at the HI or BC loop and produced in S. cerevisiae. The VLPs induced a strong immune response in mice, activated dendritic cells and T cells in spleen cell cultures and appeared therefore as a novel promising candidate of the chimeric VLPs (Gedvilaite et al. 2015). Zaveckas et al. (2018) developed a highly efficient and scalable purification procedure for the TSPyV VP1 VLPs based on two chromatographic steps, ion-exchange monolith and core-bead chromatography, which allowed recovery of 42% of TSPyV VP1 with a purity of 93% and served as an alternative to the conventional ultracentrifugation-based purification methods.
Future and Novel Unexplored Indications of Retinoids
Published in Ayse Serap Karadag, Berna Aksoy, Lawrence Charles Parish, Retinoids in Dermatology, 2019
Various other disorders have been successfully treated with retinoids as per isolated reports. These include chronic cutaneous lupus erythematosus, eruptive vellus hair cysts (124) (topical use), elastosis perforans serpiginosa (EPS) (125), scleromyxedema (126,127), and trichodysplasia spinulosa associated with HIV (128).
Cidofovir and Brincidofovir
Published in M. Lindsay Grayson, Sara E. Cosgrove, Suzanne M. Crowe, M. Lindsay Grayson, William Hope, James S. McCarthy, John Mills, Johan W. Mouton, David L. Paterson, Kucers’ The Use of Antibiotics, 2017
Graciela Andrei, Robert Snoeck
CDV therapy also proved active in two immunocompromised patients with productive infection of two novel human polyomaviruses (trichodysplasia spinulosa-associated polyomavirus and Merkel cell polyomavirus) when the drug was administered topically (Santesteban et al., 2015; van Boheemen et al., 2015; van der Meijden et al., 2010; Wanat et al., 2013) or intravenously (Maximova et al., 2013).
Analysis of human papillomaviruses and human polyomaviruses in lung cancer from Swedish never-smokers
Published in Acta Oncologica, 2020
Torbjörn Ramqvist, Christian Ortiz-Villalon, Eva Brandén, Hirsh Koyi, Luigi de Petris, Gunnar Wagenius, Ola Brodin, Christel Reuterswärd, Tina Dalianis, Mats Jönsson, Johan Staaf, Rolf Lewensohn, Maria Planck
The polyomavirus (PyV) family, currently with 14 species described from human material, has at least one member, Merkel cell polyomavirus (MCPyV) with the potential to induce tumors in humans [23]. Moreover, some animal PyVs can potentially be oncogenic in their respective hosts, e.g., murine polyomavirus (MPyV) and Raccoon polyomavirus (RacPyV) that can cause tumors in mice and raccoons, respectively [24,25]. MCPyV, discovered in 2008, is a causative factor of Merkel cell carcinoma (MCC), mostly in immunosuppressed or elderly patients [23]. Most HPyVs were discovered during the last 12 years, and although most of them are common in the human population, their potential disease association is still being evaluated. Notably, non-tumor diseases related to HPyVs, e.g., Trichodysplasia spinulosa caused by TSPyV or progressive multifocal leukoencephalopathy (PML) caused by JCPyV is mainly found in immunodeficient or immunosuppressed transplant patients [26,27]. It has therefore been suggested that also other HPyVs could potentially be oncogenic in immunosuppressed patients [27]. There are some studies investigating especially MCPyV, KIPyV, WUPyV and JCPyV as causative factors in lung cancer [15–19,28,29], but there are few studies where a larger number of HPyVs have been analyzed specifically for their potential association to lung cancer among never-smokers.