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Dermatophytosis
Published in Mahmoud A. Ghannoum, John R. Perfect, Antifungal Therapy, 2019
Mahmoud A. Ghannoum, Iman Salem, Nancy Isham
Tinea manuum is a much less prevalent infection than tinea pedis and involves the palmar, dorsal, or interdigital surface of the hands and fingernails. It may appear diffusely dry and hyperkeratotic or resemble tinea corporis (Figure 15.3). Only one hand is usually involved; however, both may be affected. Bilateral tinea pedis is also frequently an accompanying feature. Differential diagnosis includes psoriasis, eczema, dyshidrotic eczema, callous formation, secondary syphilis, contact dermatitis, and infection with nondermatophytic fungi.
Mycoses
Published in Aimilios Lallas, Enzo Errichetti, Dimitrios Ioannides, Dermoscopy in General Dermatology, 2018
Dionysios Lekkas, Francesco Lacarrubba, Anna Elisa Verzì, Giuseppe Micali
The dermoscopic pattern of tinea manuum depends on the causing fungus. Infections from zoophilic fungi usually display similar findings with those described earlier for tinea corporis (Figure 13.9B). In contrast, tinea manuum from anthropophilic fungi is dermoscopically characterized by a characteristic scaling pattern, mainly localized within the physiologic palmar creases (Figure 13.10B).4
Superficial and Mucosal Fungal Infections
Published in Johan A. Maertens, Kieren A. Marr, Diagnosis of Fungal Infections, 2007
Peter G. Pappas, Bethany Bergamo
Tinea pedis and tinea manuum are dermatophytoses of the plantar and palmar surfaces of the hands and feet, respectively, and may involve the interdigital spaces. Tinea pedis is also called athlete’s foot and ringworm of the feet. Tinea pedis is probably the most common dermatophytosis, affecting more than 70% of adult males. Chronic disease may result in onychomycosis of the toenails and/or fingernails. The most common etiologies of tinea pedis and tinea manuum include T. rubrum and T. mentagrophytes; E. folliculosum is a less common cause. The clinical presentation of tinea pedis is highly variable: hyperkeratotic or “moccasin” presentation is common and most typical of infection due to T. rubrum; interdigital tinea pedis is associated with maceration, scaling, and Assuring; inflammatory or vesicular tinea pedis is associated with vesicles and bulli involving the plantar surface of the feet; and ulcerative tinea pedis is probably the result of secondary bacterial infection complicating interdigital tinea pedis. The differential diagnosis of tinea pedis and tinea manuum include contact dermatitis, psoriasis, eczema, and keratodermas such as keratoderma blennorrhagica.
Evaluation of efficacy and safety of oral terbinafine and itraconazole combination therapy in the management of dermatophytosis
Published in Journal of Dermatological Treatment, 2020
Priyanka Sharma, Mala Bhalla, Gurvinder P. Thami, Jagdish Chander
Sixty clinically diagnosed and KOH positive (septate hyphae) patients of tinea corporis, tinea cruris, or tinea faciei participated in this open-label randomized comparative study which was conducted in accordance with the institutional ethics board and the Helsinki Declaration of 1975, as revised in 1983. Patients with co-existent tinea unguium, tinea pedis, or tinea manuum, recent use of antifungal drugs or steroids in last 4 weeks, pregnant and lactating women and those with comorbidities were excluded. The skin scrapings were subjected to culture on Sabouraud’s dextrose agar (SDA). The patients were randomly allocated to three groups of 20 each using sealed envelope method. Randomization was done by a non-treating physician not performing this study. Group I patients received terbinafine 250 mg orally once daily (TERB), group II patients received itraconazole 200 mg orally once daily (ITR), and group III patients received a combination of terbinafine 250 mg orally and itraconazole 200 mg orally once daily, both taken on the same day (TERB + ITR). Duration of therapy was 3 weeks in all the groups. Same brand of drugs were given to all the patients to rule out inter-brand variability in the efficacy of treatment.
Risk factors for cutaneous warts and the influence factors of curative effect of 5-flurouracil therapy in southern China
Published in Journal of Dermatological Treatment, 2021
Zhi P. Xiao, Que P. Liu, Hong F. Xie, Ji Li, Ming L. Chen, Dan Jian
The questionnaire was divided into four parts: socioeconomic, lifestyle, biomedical, and environmental variables. Socioeconomic variables included sex, age (years), monthly household income (Chinese ¥/month), education and occupation. Lifestyle variables included alcohol intake, smoking, physical fitness (h/week), time of sleep onset, and daily sleeping hours (h/day). Smoker was defined as those who have smoked at least one cigarette per day for ≥6 months. Alcohol drinker was defined as having consumed an alcoholic drink at least once a week for ≥6 months (6). Biomedical variables included psychological stress, frequency of cold infection, Tinea manuum, Tinea pedis, and hyperhidrosis. Psychological stress was described as a feeling of tension, anxiety, and irritability. It was measured with three components including job, school, and family-related affairs. Subjects were asked to rate the subjective feeling of impact of each event on a four-point scale: 0 (not at all), 1 (mild), 2 (moderate), and 3 (severe). Psychological stress was graded by the total sum of the three aspects to three degree: 0–3 (mild), 4–6 (moderate), and 7–9 (severe). Frequent cold infection was defined as having more than three episodes within three months during the year preceding the occurrence of cutaneous warts. Hyperhidrosis was defined as excessive bilateral and relatively symmetric sweating occurring in the palms and soles (7). Sharing personal items with others was defined as sharing nail clippers, towel, slippers, or wash basin ≥ three times within a month and lasting for more than six months. Locations of warts included foot, hand, lip, periungual skin, truncus, arm, and leg.
Nanotechnological interventions in dermatophytosis: from oral to topical, a fresh perspective
Published in Expert Opinion on Drug Delivery, 2019
Riya Bangia, Gajanand Sharma, Sunil Dogra, Om Prakash Katare
A study on systemic therapy with itraconazole suggested that it is safe and effective when 5 mg/kg was administered daily for 7 days against tinea corporis and cruris and 14 days in tinea manuum and pedis. Another review suggested its safe and effective use as the second-line drug for systemic therapy in infants with superficial dermatophytosis (5 mg/kg/day) and systemic mycoses (10 mg/kg/day). It is associated with few serious adverse effects [51]. A comparative study between itraconazole and ultra micronized griseofulvin depicted better results with 2 weeks of itraconazole therapy [52].