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PRP in Vitiligo
Published in Vineet Relhan, Vijay Kumar Garg, Sneha Ghunawat, Khushbu Mahajan, Comprehensive Textbook on Vitiligo, 2020
Blood is collected with anti-coagulant and is centrifuged at high speed. Blood separates in three layers of RBCs, BC, and plasma. BC and plasma are transferred to a second tube containing CaCl2 which triggers the clotting process and a platelet-rich fibrin matrix (PRFM) clot is obtained after centrifugation.
Regenerative Orthopedics Enabled by Cross-Cutting Technologies
Published in Kohlstadt Ingrid, Cintron Kenneth, Metabolic Therapies in Orthopedics, Second Edition, 2018
There are four different preparations of PRP as suggested by Dohan Ehrenfast [9]: P-PRP (pure platelet-rich plasma, which contains low levels of leukocytes), L-PRP (leukocyte-rich PRP), P-PRF (platelet-rich fibrin matrix with low levels of leukocytes), and L-PRF (leukocyte-rich and platelet-rich fibrin matrix) [3, 8]. Essentially, these products can vary in (a) the volume of whole blood harvested, which correlates with platelet concentration; (b) the inclusion or exclusion of leukocytes; (c) the exogenous activation of platelets, through either CaCl2, thrombin, or ultraviolet radiation creating an upregulation of leukocyte anti-inflammatory cytokines and downregulation of pro-inflammatory cytokines; and (d) the formation of a fibrin matrix [9].
Autologous platelet-rich plasma ‘fluid’ versus ‘gel’ form in combination with fractional CO2 laser in the treatment of atrophic acne scars: a split-face randomized clinical trial
Published in Journal of Dermatological Treatment, 2022
Heba I. Gawdat, Yasmin Ahmed El-Hadidy, Riham S. H. M. Allam, Heba Ahmed Abdelkader
Our results are also consistent with the results of previous studies that reported significant clinical improvement in acne scars after treatment with FCL plus PRP (13–15). Platelet-rich plasma (PRP) is a plasma fraction that contains a higher concentration of platelets relative to whole blood, typically three- to seven-fold the mean platelet concentration in whole blood (16). Platelets contain α- granules, and upon their activation, they secrete several growth factors, such as transforming growth factor-β, platelet-derived growth factor, vascular endothelial growth factor, and others (17). These growth factors and other proteins, such as adhesion molecules and chemokines, interact with the local environment to promote cell differentiation, proliferation, and regeneration (16). In addition, platelet-rich fibrin matrix has been used as an autologus filler to correct deep nasolabial folds (18).
Prospects for the application of growth factors in wound healing
Published in Growth Factors, 2020
Sanam Dolati, Mehdi Yousefi, Alireza Pishgahi, Salman Nourbakhsh, Behzad Pourabbas, Seyed Kazem Shakouri
Being a known GF and cytokine resource, Platelet-rich plasma (PRP) enjoys PGDF, TGF-α, and TGF-β1, among others (Fotouhi et al. 2018). Platelet-rich fibrin matrix (PRFM) and PRP consist of high levels of GFs that enable healing of the wounds (Martinez-Martinez, Ruiz-Santiago, and Garcia-Espinosa 2018). PRFM could be a better choice due to its slower GF release rate and higher analogy to the natural processes of wound healing and clotting (Lin and Sclafani 2018). Decellularized and dehydrated human amniotic membrane (DDHAM) products have also been demonstrated potential for resolving chronic wounds, and are clinically available (Smiell et al. 2015). Indeed DDHAM products successfully promote the resolution of chronic wounds by stimulating the secretion of important GFs, cytokines, and proteases, including PDGFs, TGF-α, TGF-β1, FGF-2, EGF, placental GF, granulocyte colony-stimulating factor (G-CSF), IL-4, IL-10, and various tissue inhibitors of metalloproteinases (TIMPs) (Sheikh, Sheikh, and Fetterolf 2014). DDHAM also increases the release of stromal cell-derived factor (SDF)-1, which is reduced in diabetic wounds and aids the recruitment of progenitor cells to the site of injury (Koob et al. 2013).
Arthroscopic knotless tape bridging with autologous platelet-rich fibrin gel augmentation: functional and structural results
Published in The Physician and Sportsmedicine, 2019
Ruben Dukan, Aude Bommier, Marc-Antoine Rousseau, Patrick Boyer
Finally, Barber and al [21]., in 2015, explored the PRP Fibrin Membrane on 40 patients. Reparations were triple-loaded single row or suture-bridging double row. The purpose of this study was to compare the clinical and radiological scores between these two techniques with the addition of platelet-rich fibrin matrix (PRFM). No superiority could be demonstrated despite Constant’s suture-bridging scores (88.3 vs. 93.0) and an identical rate of re-tears. In comparison to our series, the clinical and radiological results are similar.