China
Africa
Explore chapters and articles related to this topic
Histopathological aspects of peritoneal malignancy
Published in Tom Cecil, John Bunni, Akash Mehta, A Practical Guide to Peritoneal Malignancy, 2019
Babatunde Rowaiye, Norman Carr
Mucinous adenocarcinomas of the appendix are defined by infiltrative invasion. Histologically, this manifests as irregular angulated glands, tumour budding small pools of mucin containing malignant epithelium, and/or a desmoplastic stroma (Figure 12.3). According to the WHO definition, the term ‘mucinous adenocarcinoma’ is used when more than 50% of the tumour consists of extracellular mucin. Mucinous adenocarcinomas can be well, moderately or poorly differentiated. The presence of signet ring cells confers a worse prognosis [11–13], and tumours with these cells are classified separately in the PSOGI classification (Table 12.2) (Figure 12.4) [10]. True signet ring cells need to be distinguished from degenerative cells within mucus pools. All appendiceal adenocarcinomas, irrespective of the presence of signet ring cells, exhibit a high propensity for peritoneal metastasis [14].
Paediatric Surgery: What the Adult Surgeon Needs to Know
Published in Peter Sagar, Andrew G. Hill, Charles H. Knowles, Stefan Post, Willem A. Bemelman, Patricia L. Roberts, Susan Galandiuk, John R.T. Monson, Michael R.B. Keighley, Norman S. Williams, Keighley & Williams’ Surgery of the Anus, Rectum and Colon, 2019
Marc A. Levitt, Richard J. Wood
Mucinous adenocarcinoma is a rare histological type of colonic carcinoma in adults, occurring in about 5% of cases. In children, it is the most common type, ranging from 50% to 100%. Most are poorly differentiated and are aggressive tumours. Most cases are reported after the age of 10 years.
Helicobacter
Published in Dongyou Liu, Handbook of Foodborne Diseases, 2018
Among animal models, Mongolian gerbils are characteristic for development of expanded cystic glands, designated as heterotopic proliferative glands (HPGs), localized not only in mucosa but also up to subserosa, several months after inoculation of H. pylori.87 These lesions were initially misdiagnosed as mucinous adenocarcinoma at very high incidence (about 40%).88–90 However, actual incidence of gastric cancer was as low as 2% in carcinogen-free experiments by Hirayama et al.91 With eradication of the bacteria, HPG dramatically diminished, indicating the nature of HPG not neoplastic but rather hyperplastic lesions.87
Analysis of prognostic factors for cervical mucinous adenocarcinoma and establishment and validation a nomogram: a SEER-based study
Published in Journal of Obstetrics and Gynaecology, 2023
Yiping Hao, Qingqing Liu, Ruowen Li, Zhonghao Mao, Nan Jiang, Bingyu Wang, Wenjing Zhang, Baoxia Cui
In this study, a variety of clinical factors affecting the prognosis of patients were included. Through univariate and multivariate analysis, the independent risk factors affecting the prognosis of cervical mucinous adenocarcinoma were identified. Combined with the results of LASSO analysis, the model predicted 1-year, 3-year 5-year survival was established. An individual’s survival probability at a given point in time can be estimated by nomogram. The nomogram was a graphics-based prognostic tool that displayed clinical results. Several clinical variables are accounted for in its calculation to ensure the prediction for patients’ OS is accurate. Ni et al. calculated a nomogram based on tumour grade, stage T, N, M, tumour size, and surgery to predict cervical adenocarcinoma cancer-specific survival (Ni et al.2021). Bogani et al. developed a nomogram to predict the risk of recurrence of cervical dysplasia, and margin status and HPV persistence were important factors (Bogani et al.2022). Therefore, we aimed to create a nomogram to predict the prognosis for patients with cervical mucinous adenocarcinoma.
Immunohistochemistry as a Surrogate Marker of Underlying Molecular Derangements in Sporadic Colorectal Carcinoma in Children – A Series of Three Cases
Published in Fetal and Pediatric Pathology, 2022
Priyanka Maity, Aniket Halder, Ranajoy Ghosh, Uttara Chatterjee, Shibsankar Barman, Ruchirendra Sarkar
Histopathological examination of the colonoscopic biopsies revealed gland forming dysplastic cells including signet ring cells (Fig. 3e) floating in pools of extracellular mucin. A diagnosis of mucinous adenocarcinoma was made. Like the previous two cases, this case also showed diffuse BRAF positivity (Fig. 3f). However, the tumor cells were negative for p53 and β-catenin. The tumor cells in this case were positive for MSH2, MSH6, and MLH1 (Fig. 4a–c) but showed negative immunostaining for PMS2 (Fig. 4d), thus suggesting microsatellite instability. Genetic analysis in this patient showed BRAF-V600E mutation but did not show any germline mutation in mismatch repair genes. In addition, this patient had CpG island hypermethylation in the MLH1-promoter region.
Chemopreventive efficacy of juniper berry oil (Juniperus communis L.) on azoxymethane-induced colon carcinogenesis in rat
Published in Nutrition and Cancer, 2021
Turan Yaman, Ahmet Uyar, Ahmet Ufuk Kömüroğlu, Ömer Faruk Keleş, Zabit Yener
The production of mucin is a common histological feature in colorectal cancers. If more than 50% of the lesion consists of extracellular mucin, it is called a mucinous adenocarcinoma. This variant is characterized by accumulation of the extracellular mucin (39, 42). Signet ring cell mucinous carcinoma is a subtype of mucinous carcinoma that produces intracellular mucin (42). This subtype has a diffuse development pattern with few or no glands visible in microscopic terms. More than 50% of tumor cells have pronounced intracytoplasmic mucin. Intracellular mucin accumulation pushes the nucleus, creating a typical signet ring cell appearance. Metastasis of the lymph node, peritoneum, ovaries, and rarely the liver are observed (43, 44). In colon carcinoma, signet ring cell carcinoma can accompany other microscopic conditions at certain rates, and their presence and ratios must be specified in reports, as prognosis is quite poor (45). In this study, atypical epithelial cells with the signet ring cell appearance were detected in dense amounts in the cecum and ileocecal lymph nodes of a rat in the AOM group. However, this type of cell was not encountered in the AOM + JB group of rats.