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Dermatotoxicology of Microneedles in Man
Published in Boris Stoeber, Raja K Sivamani, Howard I. Maibach, Microneedling in Clinical Practice, 2020
John Havens Cary, Becky S. Li, Howard I. Maibach
Cunha et al. (2017) document a case of tinea corporis that emerged in corresponding locations of dermaroller use approximately 3 weeks after start of her home MN therapy for bilateral scarring of her arms and legs. Potassium hydroxide examination of the lesions was positive for fungus with lesion culture growing Microsporum canis. While the patient confirmed skin-cleaning prior and sanitation of the MN device before and after therapy, inadequate sterilization of the patient's skin and MN device cannot be excluded.
Aetiology and Laboratory Diagnosis
Published in Raimo E Suhonen, Rodney P R Dawber, David H Ellis, Fungal Infections of the Skin, Hair and Nails, 2020
Raimo E Suhonen, Rodney P R Dawber, David H Ellis
Microsporum canis is a zoophilic dermatophyte of worldwide distribution that is a frequent cause of ringworm in humans, especially children. It invades hair, skin and, rarely, nails. Cats and dogs are the main sources of infection. Invaded hairs show an ectothrix infection and fluoresce a bright greenish-yellow under Wood’s ultraviolet light. Key features include distinctive spindleshaped macroconidia, culture characteristics (Figure 1.2(a) and (b)), and abundant growth and speculation on polished rice grains and in vitro perforation of hair.
Skin infections
Published in Ronald Marks, Richard Motley, Common Skin Diseases, 2019
Trichophyton, Microsporum and Epidermophyton species are responsible for this group of dermatophyte infections. Trichophyton rubrum, T. mentagrophytes and Epidermophyton floccosum and, in the last decade, T. tonsurans are the most common causes of dermatophyte infection in humans. Microsporum canis caught from dogs, cats or other children causes tinea capitis in children and, uncommonly, other types of ringworm infection. Occasionally, a quite inflammatory ringworm can be caught from cattle (T. verrucosum) and horses (T. equinum).
Drug discovery through the isolation of natural products from Burkholderia
Published in Expert Opinion on Drug Discovery, 2021
Adam Foxfire, Andrew Riley Buhrow, Ravi S. Orugunty, Leif Smith
Following intraperitoneal administration of Cpb or Cpb iron chelate in mice at 100 mg/kg of body weight, Itoh et al. [38] found no death indicating low toxicity. Barker et al. [37] corroborated this finding, although the copper complex was significantly more toxic and had an LD50 of 50 mg/kg of body weight. Cpb had no efficacy against a systemic or cutaneous C. albicans infections in mice. Similar results were met when testing Cpb against a subcutaneous Trichomonas vaginalis infection in mice. Topical treatment using a copper complex of Cpb, in a cutaneous Microsporum canis infection model in guinea pigs, proved as effective as 1% tolnaftate positive control [37]. Additional investigations are needed to understand the cause for the lack of activity of Cpb in vivo.
The association of isoconazole–diflucortolone in the treatment of pediatric tinea corporis
Published in Journal of Dermatological Treatment, 2018
Stefano Veraldi, Rossana Schianchi, Paolo Pontini, Alberto Gorani
Tinea corporis is a common mycotic infection in children. Transmission is due to contacts with animals, humans, and soil. Microsporum canis, Trichophyton rubrum, Trichophyton mentagrophytes, and Microsporum gypseum are the species more frequently involved. Latency time ranges from one to three weeks. The face and upper limbs are usually involved. Tinea corporis presents with a single round or oval erythematous lesion, with scales in the center and well defined, vescicular borders. Pruritus is usually mild to moderate (1). Staphylococcus aureus superinfections may be observed in atopic children suffering from severe pruritus and consequent scratching. We present the results of a sponsor-free study about the use of the topical association isoconazole–diflucortolone in children with tinea corporis.
Zoonotic fungal diseases and animal ownership in Nigeria
Published in Alexandria Journal of Medicine, 2018
Adebowale I. Adebiyi, Daniel O. Oluwayelu
Several studies have indicated that domestic animals (including cats, dogs, sheep, goats, pigs, rabbits, horses, donkeys, ducks and chickens) constitute important reservoir of human dermatophytic infections in Nigeria.21,26–32 The most common agents of infection identified were the zoophilic species: Microsporum canis, Trichophyton mentagrophytes and T. verrucosum. In addition, these studies revealed that close interactions of humans with domestic animals through nomadic lifestyle, animal farming, domestic livestock keeping or pet ownership promote the prevalence of dermatophytic infections.