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Non-Melanoma Skin Cancer
Published in Pat Price, Karol Sikora, Treatment of Cancer, 2020
Irene De Francesco, Sean Whittaker, Stephen L. Morris
The diagnosis of BCCs is primarily a clinical diagnosis supported by a histopathological examination. The clinical differential diagnosis of BCC includes SCC, MM (pigmented BCC), melanocytic cystic nevi (pigmented BCC), Bowen’s disease (especially superficial BCC), psoriasis (superficial BCC), sebaceous hyperplasia, molluscum contagiosum, and numerous benign appendigeal tumors, especially those of follicular origin. Where clinical doubt exists, or when patients are referred for specialized forms of treatment a preoperative biopsy is recommended. Biopsy will also provide information on the histological subtype of the BCC, which influences management and prognosis. A specific adnexal tumor that needs to be distinguished histologically from BCC is microcystic adnexal carcinoma. This tumor is slow growing but is locally very aggressive and destructive, commonly affecting facial areas and specifically the lip. The treatment of choice is extensive surgical resection and preferably, micrographic surgery because of high rates of local recurrence.
Skin diseases of the elderly
Published in Robert A. Norman, Geriatric Dermatology, 2020
Microcystic adnexal carcinoma (MAE) is a locally aggressive cutaneous neoplasm found especially in women and has follicular and sweat gland differentiation. It involves the face, especially the upper lip and periorbital areas. It is neurotropic and rarely if ever metastasizes. Malignant fibrous histiocytoma is the most common soft tissue sarcoma of late adult life; it favors males appearing most commonly on the thighs and lower extremities. It is flesh-colored and is occasionally ulcerated. It may complicate chronic ulcers, burn scars, surgical and irradiation sites. Metastasis occurs within 2 years. Atypical fibroxanthoma is a low-grade malignancy occurring in sun-exposed areas of the head and neck of the elderly. Because of its relatively small size and superficial origin it has a more favorable prognosis.
Malignant tumors
Published in Archana Singal, Shekhar Neema, Piyush Kumar, Nail Disorders, 2019
Adenocystic sweat gland carcinoma is a rare neoplasm of which one case of a mucinous variant was observed in the tip of the great toe of a 30-year-old black female. The tumor was tender and movable.80 Its relation to adenoid cystic carcinoma and microcystic adnexal carcinoma is not entirely clear.2
A case and literature review of orbital microcystic adnexal carcinoma
Published in Orbit, 2018
Alexander J. Brent, Sundeep S. Deol, Ram Vaidhyanath, Gerald Saldanha, Raghavan Sampath
Microcystic adnexal carcinoma (MAC) is a very rare and locally aggressive sweat gland tumour. MAC has been well reported presenting as a periocular cutaneous lesion, rarely with subsequent direct orbital invasion and only once as a primary orbital lesion. Local recurrence is frequent after primary surgical excision and the role of adjuvant radiotherapy is ill-defined. We describe a case of orbital MAC treated successfully with radiotherapy after incomplete margin clearance post exenteration surgery and review the associated literature.
Microcystic adnexal carcinoma of the orbit mimicking pagetoid sebaceous gland carcinoma
Published in Orbit, 2018
Bipasha Mukherjee, Nirmala Subramaniam, Krishna Kumar, Pratheeba Devi Nivean
Immunohistochemistry was positive for cytokeratin, CK7, CD 15 (focal), Ber EP 4 (focal), and EMA. The histopathological and immunohistochemical profiles were consistent with the diagnosis of microcystic adnexal carcinoma (MAC). An oncologist was consulted, who recommended exenteration.