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Dupuytren's Contracture
Published in J. Terrence Jose Jerome, Clinical Examination of the Hand, 2022
Other lesions can be associated with the following characteristics:The disease can be localized on the dorsal face of the fingers opposite the PIP joints in the form of Garrod dorsal pads or “Knuckle pads” ( Figure 6D).Plantar lesions or Ledderhose disease appear as large, sometimes painful nodules of 2 cm in diameter at the top of the arch of the foot, in the axis of the first and second rays. There is a clear male predominance: 50% of patients with this pathology also have DC. And 2 to 15% of patients with DC will express this associated disease.Penile lesions or Lapeyronie's disease: There is a bent deformation of the erect penis and characterized by the presence of a non-elastic fibrosis of the albuginea (envelope under the skin of the penis). This deformity can cause discomfort or even the impossibility of penetration. The frequency is 1 to 3% of the population in Europe.
Plastic Surgery
Published in Gozie Offiah, Arnold Hill, RCSI Handbook of Clinical Surgery for Finals, 2019
Dupuytren’s Diathesis➣ An aggressive cohort which has an earlier onset of disease and an earlyrecurrence➣ Three classic findings: Knuckle Pads → Garrod padsFoot Involvement → Ledderhose diseasePenis Involvement → Peyronie’s disease
Case 3.5
Published in Monica Fawzy, Plastic Surgery Vivas for the FRCS(Plast), 2023
What is Dupuytrens’ disease?It is a benign fibroproliferative condition characterized by contraction of the palmar or digital fascia resulting in pits, nodules, and cords.It most commonly affects the ulnar rays of the hand in elderly men of Caucasian descent – with an increasing genetic association to mutations on chromosomes 6, 11, and 16.In some patients, it has also been found to be associated with factors such as:smoking,excessive alcohol intake,repeated injuries,diabetes, andepilepsyDupuytren’s diathesis is a more aggressive presentation with earlier disease, more rapid progression, and increased recurrence after treatment. It is more common in:males,those with early onset disease,bilateral and/or radial involvement,those with a positive family history, andthose with ectopic disease (such as Garrod’s pads affecting the dorsal PIPJ, Peyronie’s disease affecting the penis, and Ledderhose disease affecting the plantar aspect of the foot).
A post hoc analysis of Dupuytren contracture treated with collagenase Clostridium histolyticum across disease stages
Published in Journal of Plastic Surgery and Hand Surgery, 2018
Gary M. Pess, Maj Sundbom, Koo Wilson, Daniel Lindqvist, Lars B. Dahlin
Dupuytren disease (OMIM 126900) is a benign fibroproliferative progressive disorder, affecting the palmar fascia of the hands and fingers, and is characterized by flexion contracture within the joints of the fingers. The prevalence varies between populations and age groups and the disease is more common among men and in people of Northern European descent [1–3]. The disease is heterogeneous involving both genetic and environmental factors [4,5]. The onset and progression varies and occasionally other fibroproliferative conditions, such as Peyronie disease (OMIM 171000) and plantar fibromatosis (or Ledderhose disease), are associated with Dupuytren contracture.